Controlled versus assisted mechanical ventilation effects on respiratory motor output in sleeping humans

American Journal of Respiratory and Critical Care Medicine

Volumn 168, Issue 1, 2003, Pages 92-101

  Rice, Anthony J ^a   Nakayama, Hideaki C ^a   Haverkamp, Hans C ^a   Pegelow, David F ^a   Skatrud, James B ^a   Dempsey, Jerome A ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b John Rankin Lab of Pulmon Medicine   (United States)

Author keywords

Assisted mechanical ventilation; Controlled mechanical ventilation; Neuromechanical inhibition; Resetting of respiratory rhythm; Sleep

Indexed keywords

ZOLPIDEM;

ADULT; APNEA; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; EXPIRED AIR; FEMALE; HUMAN; HUMAN EXPERIMENT; INSPIRATORY CAPACITY; MALE; NORMAL HUMAN; PRESSURE; PRIORITY JOURNAL; SLEEP; TIDAL VOLUME; BREATHING MECHANICS; CENTRAL SLEEP APNEA SYNDROME; CHEMORECEPTOR; COMPARATIVE STUDY; DIAPHRAGM; FEEDBACK SYSTEM; HYPEROXIA; HYPOCAPNIA; METABOLISM; METHODOLOGY; MOTOR ACTIVITY; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; TIME; TREATMENT OUTCOME; VAGUS NERVE;

ADULT; CHEMORECEPTORS; DIAPHRAGM; FEEDBACK, BIOCHEMICAL; FEMALE; HUMANS; HYPEROXIA; HYPOCAPNIA; MALE; MOTOR ACTIVITY; POLYSOMNOGRAPHY; RESPIRATION, ARTIFICIAL; RESPIRATORY MECHANICS; SLEEP APNEA, CENTRAL; TIME FACTORS; TREATMENT OUTCOME; VAGUS NERVE;

EID: 0042805303     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200207-675OC     Document Type: Article

References (45)

1. Leevers AM, Simon PM, Dempsey JA. Apnea after normocapnic mechanical ventilation during NREM sleep. J Appl Physiol 1994;77:2079-2085.
2. Henke KG, Arias A, Skatrud JB, Dempsey JA. Inhibition of inspiratory muscle activity during sleep: chemical and non-chemical influences. Am Rev Respir Dis 1988;138:8-15.
3. Satoh M, Eastwood PR, Smith CA, Dempsey JA. Nonchemical elimination of inspiratory motor output via mechanical ventilation in sleep. Am J Respir Crit Care Med 2001;163:1356-1364.
4. Manchanda S, Leevers AM, Wilson CR, Simon PM, Skatrud JB, Dempsey JA. Frequency and volume thresholds for inhibition of inspiratory motor output during mechanical ventilation. Respir Physiol 1996;105:1-16.
5. Wilson CR, Satoh M, Skatrud JB, Dempsey JA. Non-chemical inhibition of respiratory motor output during mechanical ventilation in sleeping humans. J Physiol 1999;518:605-618.
6. Puddy A, Patrick W, Webster K, Younes M. Respiratory control during volume-cycled ventilation in normal humans. J Appl Physiol 1996;80:1749-1758.
7. Younes M. Apnea following mechanical ventilation may not be caused by neuromechanical influences. Am J Respir Crit Care Med 2001;163:1298-1300.
8. Dempsey JA, Skatrud J. Apnea following mechanical ventilation may be caused by nonchemical neuromechanical influences. Am J Respir Crit Care Med 2001;163:1297-1301.
9. Fauroux B, Isabey D, Desmarais G, Brochard L, Harf A, Lofaso F. Nonchemical influence of inspiratory pressure support on inspiratory activity in humans. J Appl Physiol 1998;85:2169-2175.
10. Lake FR, Finucane KE, Hillman DR. Diaphragm inhibition with positive pressure ventilation: quantification of mechanical effects. Respir Physiol 1999;118:149-161.
11. Knox CK. Characteristics of inflation and deflation reflexes during expiration in the cat. J Neurophysiol 1973;36:284-295.
12. Iber C, Simon PM, Skatrud JB, Mahowald MW, Dempsey JA. The Breuer-Hering reflex in humans: effects of pulmonary denervation and hypocapnia. Am J Respir Crit Care Med 1995;152:217-224.
13. Hamilton RD, Winning AJ, Horner RL, Guz A. The effect of lung inflation on breathing in man during wakefulness and sleep. Respir Physiol 1988;73:145-154.
14. Polacheck J, Strong R, Arens J, Davies C, Metcalf I, Younes M. Phasic vagal influence on inspiratory motor output in anesthetized human subjects. J Appl Physiol 1980;49:609-619.
15. BuSha BF, Judd BG, Manning HL, Simon PM, Searle BC, Duabenspeck JA, Leiter JC. Identification of respiratory vagal feedback in awake normal subjects using pseudorandom unloading. J Appl Physiol 2001; 90:2330-2340.
16. Rechtschaffen A, Kales A. A manual of standard terminology, techniques, and scoring system for sleep stages of human subjects. Bethesda, MD: National Institute for Neurological Diseases and Blindness; 1971.
17. Beck J, Gottfried SB, Nevalesi P, Skrobik Y, Comtois N, Rossini M, Sinderby C. Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure. Am J Respir Crit Care Med 2001;164:419-424.
18. Polkey MI, Hamnegard C-H, Hughes PD, Rafferty GF, Green M, Moxham J. Influence of acute lung volume change on contractile properties of human diaphragm. J Appl Physiol 1998;85:1322-1328.
19. Beck J, Sinderby C, Lindstrom L, Grassino A. Crural diaphragm activation during dynamic contractions at various inspiratory flow rates. J Appl Physiol 1998;5:451-458.
20. Froese AB, Bryan AC. Effects of anesthesia and paralysis on diaphragmatic mechanics in man. Anesthesiology 1974;41:242-255.
21. Simon PM, Zurob AS, Wies WM, Leiter JC, Hubmayr RD. Entrainment of respiration in humans by periodic lung inflations. Am J Respir Crit Care Med 1999;160:950-960.
22. Graves CL, Glass L, Laporta D, Meloche R, Grassino A. Respiratory phase locking during mechanical ventilation in anesthetized subjects. Am J Physiol 1986;250:R902-R909.
23. Skatrud JB, Dempsey JA. Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation. J Appl Physiol 1983;55:813-822.
24. Corfield D, Morrell MJ, Guz A. The nature of breathing during hypocapnia in awake man. Respir Physiol 1995;101:145-160.
25. Datta AK, Shea SA, Horner RL, Guz A. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans. J Physiol (Lond) 1991;440:17-33.
26. 2 during positive inspiratory pressure in humans. J Appl Physiol 1994;77:876-882.
27. 2. Am J Respir Crit Care Med 1997;155:2000-2009.
28. Simon PM, Skatrud JB, Badr MS, Griffin DM, Iber C, Dempsey JA. Role of airway mechanoreceptors in the inhibition of inspiration during mechanical ventilation in humans. Am Rev Respir Dis 1991;144:1033-1041.
29. Scheid P, Piiper J. Blood/gas equilibrium of carbon dioxide in lungs: a critical review. Respir Physiol 1980;39:1-31.
30. 2 in the cat. J Physiol 1992;457:177-185.
31. Lee LY, Morton RF, McIntosh MJ, Turbek JA. An isolated upper airway preparation in conscious dogs. J Appl Physiol 1986;60:2123-2127.
32. Bartoli A, Cross BA, Guz A, Jain SK, Noble MIM, Trenchard DW. The effect of carbon dioxide in the airways and alveoli on ventilation: a vagal reflex studied in the dog. J Physiol (Lond) 1974;240:91-109.
33. Cross BA, Grant BJB, Guz A, Jones PW, Semple SJG, Stidwill RP. Dependence of phrenic motoneurone output on the oscillatory component of arterial blood gas composition. J Physiol 1979;290:163-184.
34. 2 load. J Appl Physiol 1981;50:45-54.
35. CO2 in control of breathing of awake exercising dogs. J Appl Physiol 1984;56:1335-1337.
36. 2 oscillations on respiratory control at rest. J Appl Physiol 1991;70:1601-1606.
37. Rodman JR, Curran AK, Henderson KS, Dempsey JA. Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 2001;91:328-335.
38. Lahiri S, Delaney RG. Stimulus interaction in the response of the carotid body chemoreceptor single afferent fibers. Respir Physiol 1975;24:249-266.
39. Nakayama H, Smith CA, Rodman JR, Skatrud JB, Dempsey JA. Carotid body denervation eliminates apnea in response to transient hypocapnia. J Appl Physiol 2003;94:155-164.
40. Simon P, Dempsey JA, Landry DM, Skatrud JB. Effects of sleep on respiratory muscle activity during mechanical ventilation. Am Rev Respir Dis 1993;147:32-37.
41. Meza S, Mendez M, Ostrowski M, Younes M. Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects. J Appl Physiol 1998;85:1929-1940.
42. Simon P, Habel AM, Daubenspeck JA, Leiter JC. Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans. J Appl Physiol 2000;89:760-769.
43. Lewis J, Bachoo M, Polosa C, Glass L. The effects of superior laryngeal nerve stimulation on the respiratory rhythm: phase resetting and after effects. Brain Res 1989;517:44-50.
44. CO2 partial pressure. J Appl Physiol 1982;53:105-109.
45. Leevers AM, Simon PM, Xi L, Dempsey JA. Apnoea following normocapnic mechanical ventilation: a demonstration of control system inertia. J Physiol (Lond) 1993;472:749-768.