Reduced hepatic glycogen stores in patients with liver cirrhosis

Liver International

Volumn 23, Issue 2, 2003, Pages 101-109

  Krähenbühl, Lukas ^a   Lang, Corinne ^a   Lüdes, Saskia ^b   Seiler, Christian ^a   Schäfer, Markus ^a   Zimmermann, Arthur ^a   Krähenbühl, Stephan ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Glucokinase; Glycogen; Glycogen phosphorylase; Glycogen synthase; Liver cirrhosis

Indexed keywords

GLUCOKINASE; GLYCOGEN; GLYCOGEN SYNTHASE; PHOSPHORYLASE; 3 HYDROXYBUTYRIC ACID; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILE ACID; BILIRUBIN; BIOLOGICAL MARKER; GLYCOGEN PHOSPHORYLASE; HEXOKINASE; MESSENGER RNA; SERUM ALBUMIN;

ADULT; ALCOHOL LIVER CIRRHOSIS; ARTICLE; BILIARY CIRRHOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GASTROINTESTINAL ABSORPTION; GENE EXPRESSION; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CELL; LIVER CIRRHOSIS; LIVER SURGERY; LIVER WEIGHT; MORPHOMETRICS; PATHOPHYSIOLOGY; AGED; BLOOD; COMPARATIVE STUDY; CYTOLOGY; ENZYMOLOGY; EVALUATION; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY;

3-HYDROXYBUTYRIC ACID; AGED; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; BILE ACIDS AND SALTS; BILIRUBIN; BIOLOGICAL MARKERS; BLOOD GLUCOSE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; HEPATOCYTES; HEXOKINASE; HUMANS; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; LIVER CIRRHOSIS, BILIARY; LIVER GLYCOGEN; MIDDLE AGED; RNA, MESSENGER; SERUM ALBUMIN;

EID: 0042787673     PISSN: 14783223     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0676.2003.00805.x     Document Type: Article

References (41)

1. Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998; 336: 19-31.
2. Talmadge R J, Silverman H. Glucose uptake and glycogen synthesis in normal and chronically active muscles. Am J Physiol 1993; 264: E328-E333.
3. Carabaza A, Ricart M D, Mor A, Guinovart J J, Ciudad C J. Role of AMP on the activation of glycogen synthase and phosphorylase by adenosine, fructose, and glutamine in rat hepatocytes. J Biol Chem 1990; 265: 2724-32.
4. Ciudad C J, Carabaza A, Guinovart J J. Glucose 6-phosphate plays a central role in the activation of glycogen synthase by glucose in hepatocytes. Biochem Biophys Res Commun 1986; 141: 1195-200.
5. Beynen A C, Geelen M J. Control of glycogen metabolism by insulin in isolated hepatocytes. Horm Metab Res 1981; 13: 376-8.
6. Roden M, Perseghin G, Petersen K F, et al. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 1996; 97: 642-8.
7. Ercan N, Gannon M C, Nuttall F Q. Effects of glucagon with or without insulin administration on liver glycogen metabolism. Am J Physiol 1995; 269: E231-E238.
8. Salhanick A I, Chang C L, Amatruda J M. Hormone and substrate regulation of glycogen accumulation in primary cultures of rat hepatocytes. Biochem J 1989; 261: 985-92.
9. Johnson L N, Barford D. Glycogen phosphorylase. The structural basis of the allosteric response and comparison with other allosteric proteins. J Biol Chem 1990; 265: 2409-12.
10. Keppens S, De Wulf H. P2-purinergic control of liver glycogenolysis. Biochem J 1985; 231: 797-9.
11. Keppens S, Vandekerckhove A, Moshage H, Yap S H, Arts R, De Wulf H. Regulation of glycogen phosphorylase activity in isolated human hepatocytes. Hepatology 1993; 17: 610-14.
12. Krähenbühl S, Weber F L, Brass E P. Decreased hepatic glycogen content and accelerated response to starvation in rats with carbon tetrachloride-induced cirrhosis. Hepatology 1991; 14: 1189-95.
13. Krähenbühl L, Talos C, Reichen J, et al. Progressive decrease in tissue glycogen content in rats with long-term cholestasis. Hepatology 1996; 24: 902-7.
14. Kudrayavtseva M V, Besborodkina N N, Kudrayavtseva B N. Restoration of the glycogen-forming function of hepatocytes in rats with liver cirrhosis is facilitated by a high-carbohydrate diet. Br J Nutr 1999; 81: 473-80.
15. Owen O E, Reichle A, Mozzoli M A, et al. Hepatic, gut and renal substrate flux rates in patients with hepatic cirrhosis. J Clin Invest 1981; 68: 240-52.
16. Krähenbühl S, Reichen J. Decreased hepatic glucose production in rats with carbon tetrachloride-induced liver cirrhosis. J Hepatol 1993; 19: 64-70.
17. Kabadi U M. The association of hepatic glycogen depletion with hyperammonemia in cirrhosis. Hepatology 1987; 7: 821-4.
18. Bugianesi E, Kalhan S, Burkett E, McCullough A. Quantification of gluconeogenesis in cirrhosis: response to glucagon. Gastroenterology 1998; 115: 1530-40.
19. Olsen C. An enzymatic fluorometric micromethod for the determination of acetoacetate, β-hydroxybutyrate, pyruvate and lactate. Clin Chim Acta 1971; 33: 293-300.
20. Sherlock S, Dooley J. Diseases of the Liver and Biliary System, 9th edn. Oxford: Blackwell Scientific Publications, 1993.
21. Weibel E R. Stereological Methods. London: Academic Press, 1979.
22. Gross J B, Reichen J, Zeltner T B, Zimmermann A. The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass. Hepatology 1987; 7: 457-63.
23. Lust W D, Passonneau J V, Crites S K. The measurement of glycogen in tissues by amylo-alpha- 1, 4-alpha-1, 6-glucosidase after the destruction of preexisting glucose. Anal Biochem 1975; 68: 328-31.
24. Thomas J A, Schlender K, Larner J. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem 1968; 25: 486-99.
25. Guinovart J, Salavert A, Massague J, Ciudad C J, Salsas E, Itarte E. Glycogen synthase: a new activity ratio assay expressing a high sensitivity to the phosphorylation state. FEBS Lett 1979; 106: 284-8.
26. Gilboe D P, Larson K L, Nuttall F Q. Radioactive method for the assay of glycogen phosphorylases. Anal Biochem 1972;47:20-7.
27. Theen J, Gilboe D P, Nuttall F Q. Liver glycogen synthase and phosphorylase changes in vivo with hypoxia and anesthetics. Am J Physiol 1982; 243: E182-E187.
28. Agius L, Tosh D. Acinar zonation of cytosolic but not organelle-bound activities of phosphoenolpyruvate carboxykinase and aspartate aminotransferase in guinea-pig liver. Biochem J 1990; 271: 387-91.
29. Lowes W, Walker M, Alberti K G, Agius L. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. Biochim Biophys Acta 1998; 1379: 134-42.
30. Sambrook J, Fritsch E F, Maniatis T. Molecular Cloning, a Laboratory Manual, 2nd edn. New York: Cold Spring Harbor Laboratory Press, 1989.
31. Herrera E, Freinkel N. Interrelationships between liver composition, plasma glucose and ketones, and hepatic acetyl-CoA and citric acid during prolonged starvation in the male rat. Biochim Biophys Acta 1968; 170: 244-53.
32. Cahill G F, Herrera M G, Morgan A P, et al. Hormone-fuel interrelationships during fasting. J Clin Invest 1966; 45: 1751-69.
33. Nilsson L H. Liver glycogen content in man in the postabsorptive state. Scand J Clin Lab Invest 1973; 32: 317-23.
34. Nilsson L H, Hultman E. Liver glycogen in man - the effect of total starvation or a carbohydrate-poor diet followed by carbohydrate-refeeding. Scand J Clin Lab Invest 1973; 32: 325-30.
35. Kabadi U M, Eisenstein A B, Tucci J, Pellicone J. Hyper-glucagonemia in hepatic cirrhosis: its relation to hepatocellular dysfunction and normalization on recovery. Am J Gastroenterol 1984; 79: 143-9.
36. Gomis R R, Cid E, Garcia-Rocha M, Ferrer J C, Guinovart J J. Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase. J Biol Chem 2002; 277: 23246-52.
37. Racine-Samson L, Scoazec J-Y, D'Errico A, et al. The metabolic organization of the adult human liver: a comparitive study of normal, fibrotic, and cirrhotic liver tissue. Hepatology 1996; 24: 104-13.
38. Katz N, Teutsch H F, Jungermann K, Sasse D. Heterogeneous reciprocal localization of fructose-1, 6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue. FEBS Lett 1977; 83: 272-6.
39. Owen O E, Trapp V E, Reichard G A, et al. Nature and quantity of fuels consumed in patients with alcoholic liver cirrhosis. J Clin Invest 1983; 72: 1821-32.
40. Italian Multicentre Cooperative Project On Nutrition In Liver Cirrhosis. Nutritional status in cirrhosis. J Hepatol 1994; 21: 317-25.
41. Pirlich M, Selberg O, Boker K, Schwarze M, Muller M J. The creatinine approach to estimate skeletal muscle mass in patients with cirrhosis. Hepatology 1996; 24: 1422-7.