A practical synthesis of α-amino ketones via aryllithium addition to N-Boc-α-amino acids

Synthesis

Volumn , Issue 11, 2003, Pages 1653-1656

  Florjancic, Alan S ^a   Sheppard, George S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Amino acids; Arylations; Ketones; Lithiation; Nucleophilic additions

Indexed keywords

ADDITION REACTIONS; AMINO ACIDS; DRUG PRODUCTS; SYNTHESIS (CHEMICAL);

ARYLLITHIUM REAGENTS;

KETONES;

ALPHA AMINO ACID; AMIDE; KETONE; LITHIUM; MATRIX METALLOPROTEINASE INHIBITOR; PHENYLALANINE;

ARTICLE; ARYLATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LITHIATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 0042739251     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-40875     Document Type: Article

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20. HPLC analysis with ChiralPak AD 4.6 × 250 mm column from Chiral Technologies. Solvent system: 25-40% EtOH in hexanes.