Enantiospecific synthesis of α-amino ketones and β-amino alcohols from the reaction of N-(9-phenylfluoren-9-yl)-alanine oxazolidinone with organolithium reagents

Tetrahedron Letters

Volumn 37, Issue 19, 1996, Pages 3403-3406

  Paleo, M Rita ^a   Sardina, F Javier ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOALCOHOL;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; REACTION ANALYSIS; TECHNIQUE;

EID: 0029987982     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00557-6     Document Type: Article

References (22)

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15. 2: C, 80.92; H, 5.61; N, 4.10. Found: C, 80.78; H, 6.00; N, 4.23.
16. All new compounds showed the expected spectral properties and gave satisfactory elemental analyses.
17. 21NO: C, 84.37; H, 6.46; N, 4.28. Found: C, 84.31; H, 6.86; N, 4.40.
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20. + in the corresponding intermediates cannot bind to the fluorenyl ring of the Pf group.
21. A 99:1 mixture of 6a:6b showed two signals clearly distinguishable for H3. The spectra of crude 6a or 6b showed only one signal for H3.
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