Nicotinamide: A potential addition to the anti-psoriatic weaponry

FASEB Journal

Volumn 17, Issue 11, 2003, Pages 1377-1379

  Namazi, Mohammad Reza ^a,b  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b NONE   (Iran)

Author keywords

AIDS; Interleukin 12; Nicotinamide; PARP psoriasis; Protein kinase C; T helper cell; Treatment; Tumor necrosis factor alpha

Indexed keywords

ANTIPSORIASIS AGENT; CD38 ANTIGEN; CELL ADHESION MOLECULE; CERAMIDE; CHEMOKINE; CYTOKINE; HISTAMINE; INTERLEUKIN 1; INTERLEUKIN 12; METHOTREXATE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITOR; PROTEIN KINASE C; PROTEINASE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTHRITIS; CELL PROLIFERATION; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG INHIBITION; HELPER CELL; HISTAMINE RELEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATORY DISEASE; LIVER TOXICITY; LYMPHOCYTE TRANSFORMATION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOGENESIS; PRIORITY JOURNAL; PSORIASIS; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; MICE; NIACINAMIDE; PSORIASIS;

HUMAN IMMUNODEFICIENCY VIRUS; MURINAE;

EID: 0042710791     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-0002hyp     Document Type: Review

References (28)

1. Ortonne, J. P. (1999) Recent developments in the understanding of the pathogenesis of psoriasis. Br. J. Dermatol. 140 (Suppl. 54), 1-7
2. Krueger, J. G. (2002) The immunologic basis for the treatment of psoriasis with new biologic agents. J. Am. Acad. Dermatol. 46, 1-23
3. Weller, R., Ormerod, A., and Benjamin, N. (1996) Nitric oxide generation measured directly from psoriatic plaques by chemiluminescence. Br. J. Dermatol. 134, 569
4. Weller, R., and Ormerod, A. (1997) Increased expression of nitric oxide synthase. Br. J. Dermatol. 136, 132-148
5. Namazi, M. R. (2003) A complementary note on the Morhenn's hypothesis on the pathomechanism of psoriasis. Immunol. Lett. In press
6. Fraki, J. E., Lazarus, G. S., Gilgor, R. S., Marchase, P., and Singer, K. H. (1983) Correlation of epidermal plasminogen activator activity with disease activity in psoriasis. Br. J. Dermatol. 108, 39-44
7. Christophers, E., and Mrowietz, U. (1999) Psoriasis. In Fitzpatrick's Dermatology in General Medicine (Freedberg, I. M., Eisen, A. Z., Wolff, K., Austen, K. F., Goldsmith L. A., et al., eds) 5th Ed, Vol. 1, pp. 495-521, McGraw-Hill, New York
8. Petersen, L. J., Hansen, U., Kristensen, J. K., Nielsen, H., Skov, P. S., and Nielsen, H. J. (1998) Studies on mast cells and histamine release in psoriasis: the effect of ranitidine. Acta Derm. Venereol. 78, 190-3
9. Maoqiang, M., and Fusheng, W. (1992) Treatment of psoriasis with aminophylline. Int. J. Dermatol. 31, 370-1
10. Raynaud, F., Gerbaud, P., and Evain-Brion, D. (1994) Beneficial effect of a combination of retinoids and long-acting theophyl-line in the treatment of psoriasis vulgaris. Br. J. Dermatol. 131, 740-1
11. Stratford, M. R. L., Rajas, A., Hall, D. W., Dennis, M. F., Dische, S., Joiner, M. C., et al. (1992) Pharmacokinetics of nicotinamide and its effects on blood pressure, pulse and body temperature in normal human volunteers. Radiother. Oncol. 25, 37-42
12. Virag, L., and Szabo, C. (2002) The therapeutic potential of poly (ADP-ribose) polymerase inhibitors. Pharmacol. Rev. 54, 375-429
13. Hiromatsu, Y., Sato, M., Tanaka, K., Ishisaka, N., Kamachi, J., and Nonaka, K. (1993) Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells. Immunology 80, 330-2
14. Pellat-Deceunynck, C., Wietzerbin, J., and Drapier, J. C. (1994) Nicotinamide inhibits nitric oxide synthase mRNA induction in activated macrophages. Biochem. J. 297, 53-58
15. Kretowski, A., Mysliwiec, J., Szelachowska, M., Kinalski, M., and Kinalski, I. (2000) Nicotinamide inhibits enhanced in vitro production of interleukin-12 and tumor necrosis factor-alpha in peripheral whole blood of people at high risk of developing type 1 diabetes and people with newly diagnosed type 1 diabetes. Diabetes Res. Clin. Pract. 47, 81-86
16. Kolb, H., and Burkart, V. (1999) Nicotinamide in type 1 diabetes: mechanism of action revisited. Diabetes Care 22 (Suppl. 2), B16-B20
17. Meisel, M., Kurpisz, M., and Kroger, H. (1995) Modulation of inflammatory arthritis by inhibition of poly (ADP-ribose) polymerase. Inflammation 19, 379-387
18. Tanno, O., Ota, Y., Kitamura, N., Katsube, T., and Inoue, S. (2000) Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve epidermal permeability barrier. Br. J. Dermatol. 143, 524-531
19. Wertz, P. W., and Downing, D. T. (1990) Free sphingosine in human epidermis. J. Invest. Dermatol. 94, 159-161
20. Okazaki, T., Bell, R. M., and Hannun, Y.A. (1989) Sphingomyelin turnover induced by vitamin D3 in HL-60 cells: role in cell differentiation. J. Biol. Chem. 261, 19076-19080
21. Okazaki, T., Bielawska, A, and Bell, R. M. (1990) Role of ceramide as a lipid mediator of alpha, 25-dihydroxy vitamin D3-induced HL-60 cell differentiation. J. Biol. Chem. 265, 15823-15831
22. Burger, D. R., Vandenbark, A. A., Daves, D., Anderson, W. A., Jr., Vetto, R. M., and Finke, P. (1976) Nicotinamide suppression of lymphocyte transformation with a component identified in human transfer factor. J. Immunol. 117, 797-801
23. Kroger, H., Miesel, R., Dietrich, A., Ohde, M., Rajnavolgyi, E., and Ockenfeld, H. (1996) Synergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice. Inflammation 20, 203-215
24. Cather, J., and Menter A. (2002) Novel therapies for psoriasis. Am. J. Clin. Dermatol. 3, 159-173
25. Kroger, H., Hauschild, A., Ohde, M., Thefeld, W., Kruger, D., Bache, K., et al. (1998) Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide. Inflammation 22, 277-285
26. Kroger, H., Hauschild, A., Ohde, M., Bache, K., Voigt, W. P., Thefeldt, W., et al. (1999) Nicotinamide and methionine reduce the liver toxic effect of methotrexate. Gen. Pharmacol. 33, 203-206
27. Wyczolkowska, J., and Maslinski, C. (1975) lnhibition by nicotinamide of an homologous PCA reaction and antigen-induced histamine release from rat peritoneal mast cells. Int. Arch. Allergy Appl. Immunol. 49, 285-292
28. Berk, M. A., and Lorincz, A. L. (1986) The treatment of bullous pemphigoid with tetracycline and nicotinamide: a preliminary report. Arch. Dermatol. 122, 670-4