The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats

Journal of Urology

Volumn 170, Issue 4 I, 2003, Pages 1437-1442

  Usta, Mustafa F ^a   Bivalacqua, Trinity J ^a   Yang, Dae Yul ^a   Ramanitharan, Anshiya ^a   Sell, David R ^b   Viswanathan, Ashiwini ^b   Monnier, Vincent M ^b   Hellstrom, Wayne J G ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Advanced; Diabetes mellitus; Glycosylation end products; Impotence; Penis; Rats; Sprague Dawley

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; COLLAGEN; FUROSINE; GALECTIN 3; GLUCOSE; NITRIC OXIDE SYNTHASE; PENTOSIDINE; PROTEIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; GLYCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PENIS ERECTION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

EID: 0042692857     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000077557.45582.f3     Document Type: Article

References (20)

1. Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J. and McKinlay, J. B.: Impotence and its medical psychosocial correlates: results of the Massachusetts male aging study. J Urol, 151: 54, 1994
2. Bivalacqua, T. J., Champion, H. C., Hellstrom, W. J. and Kadowitz, P. J.: Pharmacotherapy for erectile dysfunction. Trends Pharmacol Sci, 21: 484, 2000
3. Saenz de Tejada, I., Goldstein, I., Azadzoi, K., Krane, R. J. and Cohen, R. A.: Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med, 320: 1025, 1989
4. Burnett, A. L.: Nitric oxide in the penis: physiology and pathology. J Urol, 157: 320, 1997
5. Usta, M. F., Tuncer, M., Baykal, A., Ciftcioglu, M. A., Erdogru, T., Koksal, I. T. et al: Impact of chronic renal failure and peritoneal dialysis fluids on advanced glycation end product and iNOS levels in penile tissue: an experimental study. Urology, 59: 953, 2002
6. McVary, K. T., Rathnau, C. H. and McKenna, K. E.: Sexual dysfunction in diabetic BB/WOR rat: a role of central neuropathy. Am J Physiol, 272: R259, 1997
7. Bivalacqua, T. J., Usta, M. F., Champion, H. C., Adams, D., McNamara, D. B., Abdel-Mageed, A. B. et al: Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats. J Urol, 169: 1911, 2003
8. Podlasek, C. A., Zelner, D. J., Bervig, T. R., Gonzalez, C. M., McKenna, K. E. and McVary, K. T.: Characterization and localization of nitric oxide synthase isoforms in the BB/WOR diabetic rat. J Urol, 166: 746, 2001
9. Seftel, A. D., Vaziri, N. D., Ni, Z., Razmjouei, K., Fogarty, J., Hampel, N. et al: Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology, 50: 1016, 1997
10. Singh, R., Barden, A., Mori, T. and Beilin, L.: Advanced glycation end-products: a review. Diabetologia, 44: 129, 2001
11. Vlassara, H.: The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab Res Rev, 17: 436, 2001
12. Pugliese, G., Pricci, F., Leto, G., Amadio, L., Iacobini, C., Romeo, G. et al: The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression. Diabetes, 49: 1249, 2000
13. Tomlinson, K. C., Gardiner, S. M., Hebden, R. A. and Bennett, T.: Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol Rev, 44: 103, 1992
14. Bivalacqua, T. J., Champion, H. C., Leungwattanakij, S., Yang, D. Y., Hyun, J. S., Abdel-Mageed, A. B. et al: Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie's-like condition in the rat. J Androl, 22: 497, 2001
15. Sell D. R., Nelson, J. F. and Monnier, V. M.: Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat. J Gerontol A Biol Sci Med Sci, 56: B405, 2001
16. Giuliano, F. A., Rampin, O., Benoit, G. and Jardin, A.: Neural control of penile erection. Urol Clin North Am, 22: 747, 1995
17. Kaltner, H., Seyrek, K., Heck, A., Sinowatz, F. and Gabius, H. J.: Galectin-1 and galectin-3 in fetal development of bovine respiratory and digestive tracts. Comparison of cell type-specific expression profiles and subcellular localization. Cell Tissue Res, 307: 35, 2002
18. Mass, M., Schwedhelm, E., Albsmeier, J. and Boger, R. H.: The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med, 7: 213, 2002
19. Cartledge, J. J., Eardley, I. and Morrison, J. F.: Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes. BJU Int, 87: 402, 2001
20. Bivalacqua, T. J., Diner, E. K., Novak, T. E., Vohra, Y., Sikka, S. C., Champion, H. C. et al: A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression. J Urol, 163: 1992, 2000