The effects of paroxetine on rat isolated vas deferens

Pharmacological Research

Volumn 48, Issue 4, 2003, Pages 335-345

  Yaris, Ersin ^a   Kesim, Murat ^a   Kadioglu, Mine ^a   Kalyoncu, Nuri Ihsan ^a   Ulku, Cunay ^a   Ozyavuz, Rasin ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Paroxetine; Rat; Reserpine; Selective serotonin re uptake inhibitors; Vas deferens

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ADENOSINE TRIPHOSPHATE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; NORADRENALIN; PAROXETINE; POTASSIUM CHLORIDE; PRAZOSIN; SEROTONIN UPTAKE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ELECTROSTIMULATION; EPIDIDYMIS; ISOLATED ORGAN; MALE; MUSCLE EXCITATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

EID: 0042668486     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00157-9     Document Type: Article

References (22)

1. Wagstaff A.J., Cheer S.M., Matheson A.J., Ormrod D., Goa K.L. Paroxetine: an update of its use in psychiatric disorders in adults. Drugs. 62(4):2002;655-703.
2. Bourin M., Chue P., Guillon Y. Paroxetine: a review. CNS Drug Rev. 7(1):2001;25-47.
3. Muijsers R.B., Plosker G.L., Noble S. Sertraline: a review of its use in the management of major depressive disorder in elderly patients. Drugs Aging. 19(5):2002;377-392.
4. Ekselius L., von Knorring L. Effect on sexual function of long-term treatment with selective serotonin reuptake inhibitors in depressed patients treated in primary care. J. Clin. Psychopharmacol. 21(2):2001;154-160.
5. McMahon C.G. Treatment of premature ejaculation with sertraline hydrochloride. Int. J. Impot. Res. 10(3):1998;181-184.
6. Waldinger M.D., Zwinderman A.H., Olivier B. Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. J. Clin. Psychopharmacol. 21(3):2001;293-297.
7. Waldinger M.D., Hengeveld M.W., Zwinderman A.H. Ejaculation-retarding properties of paroxetine in patients with primary premature ejaculation: a double-blind, randomized, dose-response study. Br. J. Urol. 79:1997;592-595.
8. Kalyoncu N.I., Ozyavuz R., Karaoglu S. Sertraline inhibits the contractile responses to noradrenaline, KCl and electrical field stimulation of rat isolated vas deferens. J. Auton. Pharmacol. 19:1999;365-369.
9. Boselli C, Bianchi L, Barbieri A, Grana E. Effect of calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens. J Auton Pharmacol 1998;18(5):297-306.
10. Brown D.A., Docherty J.R., French A.M., MacDonald A., McGrath J.C., Scott N.C. Separation of adrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens. Br. J. Pharmacol. 79:1983;379-393.
11. Waldinger MD, van De Plas A, Pattij T, van Oorschot R, Coolen LM, Veening JG, Olivier B. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differs in sexual inhibitory effects after chronic treatment. Psychopharmacol 2002;160(3)283-9.
12. Anton P.G., Duncon M.E., Mc Grath J.C. An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens. J. Physiol. Lond. 273:1977;23-43.
13. Hay D.W., Wadsworth R.M. KCl contractions in the rat intact and bisected vas deferens. Contribution of endogenous noradrenaline release. Clin. Exp. Pharmacol. Physiol. 10(1):1983;77-86.
14. +-free medium and ouabain, but not by high KCl in vas deferens of guinea-pig and rat. Eur. J. Pharmacol. 81(2):1982;217-225.
15. Katsuragi T., Tokunaga T., Miyamoto K., Kuratomi L., Furukawa T. Norepinephrine and adenosine triphosphate release in different ratio from guinea pig vas deferens by high potassium chloride, ouabain and monensin. J. Pharmacol. Exp. Ther. 247(1):1988;302-308.
16. Von Kugelgen I., Kurtz K., Starke K. Axon terminal P2-purinoceptors in feedback control of sympathetic transmitter release. Neuroscience. 56(2):1993;263-267.
17. 1-Adrenoceptors and calcium sources in adrenergic neurogenic contractions of rat vas deferens. Br J Pharmacol 1994;111(1):151-8.
18. Valasco A., Maroto M., Saez G.C., Duenas A. Effects of paroxetine and sertraline on different tissues from the guinea-pig and rat. Med. Sci. Res. 25:1997;93-96.
19. Steers W.D. Physiology of the vas deferens. World J. Urol. 12:1994;281-285.
20. Seo K.K., Kim S.C., Lee M.Y. Comparison of peripheral inhibitory effects of clomipramine with selective serotonin re-uptake inhibitors on contraction of vas deferens: in vitro and in vivo studies. J. Urol. 165(6, Pt 1):2001;2110-2114.
21. Kim S.C., Seo K.K., Han J.H., Lee M.Y. Inhibitory effect of serotonergic drugs on contractile response of the rat vas deferens to electrical nerve stimulation: in vivo study. J. Urol. 163(6):2000;1988-1991.
22. Kara H., Aydin S., Yucel M., Agargun M.Y., Odabas O., Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo-controlled study. J. Urol. 156(5):1996;1631-1632.