Pulmonary dysfunction in transfusion-dependent patients with thalassemia major

American Journal of Respiratory and Critical Care Medicine

Volumn 168, Issue 2, 2003, Pages 180-184

  Carnelli, Vittorio ^a   D'Angelo, Emanuela ^a   Pecchiari, Matteo ^a   Ligorio, Massimo ^a   D'Angelo, Edgardo ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Alveolar capillary membrane; Iron overload; Lung mechanics; Pulmonary capillary blood volume; Pulmonary diffusing capacity

Indexed keywords

CARBON DIOXIDE; CHELATING AGENT; DEFERIPRONE; DEFEROXAMINE; HEMOGLOBIN; IRON;

ADULT; ARTICLE; BLOOD TRANSFUSION; CHELATION THERAPY; CORRELATION ANALYSIS; EXPIRATORY FLOW; FEMALE; FORCED EXPIRATORY VOLUME; HEMOGLOBIN DETERMINATION; HUMAN; IRON OVERLOAD; LUNG DIFFUSION CAPACITY; LUNG DISEASE; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; THALASSEMIA MAJOR; VITAL CAPACITY;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CHILD; FEMALE; HUMANS; LUNG DISEASES; MALE; PULMONARY DIFFUSING CAPACITY; PULMONARY EDEMA; PULMONARY FIBROSIS; RESPIRATORY MECHANICS; SPIROMETRY;

EID: 0042666836     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200211-1292OC     Document Type: Article

References (26)

1. Cooper DM, Mansell AL, Weiner MR, Berdon WA, Chetty-Baktaviziam A, Reid L, Mellins RB. Low lung capacity and hypoxemia in children with thalassemia major. Am Rev Respir Dis 1980;121:639-646.
2. Grisaru D, Rachmilewitz EA, Mosseri M, Gotsman M, Lafair JS, Okon E, Goldfarb A, Hasin Y. Cardiopulmonary assessment in β-thalassemia major. Chest 1990;98:1138-1142.
3. Factor JM, Pottipati SR, Rappaport I, Rosner IK, Lesser ML, Giardina PJ. Pulmonary function abnormalities in thalassemia major and the role of iron overload. Am J Respir Crit Care Med 1994:149:1570-1574.
4. Tai DYH, Wang YT, Lou J, Wang WY, Mak KH, Cheng HK. Lungs in thalassaemia major patients receiving regular transfusion. Eur Respir J 1996;9:1389-1394.
5. Piatti G, Allegra L, Ambrosetti U, Cappellini MD, Turati F, Fiorelli G. Thalassemia and pulmonary function. Haematologica 1999;84:804-808.
6. Keens TG, O'Neal MH, Ortega JA, Hyman CB, Platzker ACG. Pulmonary function abnormalities in thalassemia patients on a hypertransfusion program. Pediatrics 1980;65:1013-1017.
7. Hoyt RW, Scarpa N, Wilmott RW, Cohen A, Schwartz E. Pulmonary function abnormalities in homozygous β-thalassemia. J Pediatr 1986;109:452-455.
8. Santamaria F, Villa MP, Ronchetti R. Pulmonary function abnormalities in thalassemia major. Am J Respir Crit Care Med 1995;151:919.
9. Cazal P. Siderose massive d'origine transfusionelle avec fibrose plurevisceral au cours d'une maladie de Cooley. Ann Anat Pathol (Paris) 1963;8:129-148.
10. Cappell DF, Hutchinson HE, Jowett M. Transfusional siderosis: the effect of excessive iron deposits on the tissue. J Pathol Bacteriol 1975;74:245-264.
11. Witzleben CL, Wyatt JP. The effect of long survival on the pathology of thalassaemia major. J Pathol Bacteriol 1961;82:1-13.
12. Roughton FJW, Forster RE. Relative importance of diffusion and chemical reaction rates in determining rate of the exchange of gases in human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol 1957;11:290-302.
13. Miles LEM, Lipschitz DA, Bieber CP, Cool JD. Measurements of ferritin by a 2-site immunoradiometric assay. Ann Biochem 1974;61:209-224.
14. Quanier PJ. Standardized lung function testing: standardization of lung function tests. Report of the Working Party. Bull Eur Physiopathol Respir 1983;19:1-95.
15. Bucci G, Cook CD, Barrie H. Studies of respiratory physiology in children: V. Total lung diffusion, diffusing capacity of pulmonary membrane, and pulmonary capillary blood volume in normal subjects from 7 to 40 years of age. J Pediatr 1961:58:820-828.
16. Cotes JE, Dabbs JM, Elwood PC, Hall AM, McDonald A, Saunders MJ. Iron-deficiency anaemia: its effect on transfer factor for the lung (diffusing capacity) and ventilation and cardiac frequency during submaximal exercise. Clin Sci 1972;42:325-335.
17. Cotes JE, Dabbs JM, Hall AM, Axford AT, Laurence KM. Lung volumes, ventilatory capacity, and transfer factor in healthy British boy and girl twins. Thorax 1973;28:709-715.
18. McNeill RC, Rankin J, Forster RE. The diffusing capacity of the pulmonary membrane and the pulmonary capillary blood volume in cardiopulmonary disease. Clin Sci 1958;17:465-482.
19. Bucher U, Reid L. Development of the intrathoracic bronchial tree: the pattern of branching. Thorax 1961;16:207-218.
20. Mansell AL, Bryan AC, Levison M. Relationship of lung recoil to lung volume and maximum expiratory flow in normal children. J Appl Physiol 1977;42:817-823.
21. De Troyer A, Yernault JC, Englert M, Baran D, Paiva M. Evolution of intrathoracic airway mechanics during lung growth. J Appl Physiol 1978;44:521-527.
22. Dimopoulou I, Kremastinos DT, Maris TG, Mavrogeni S, Tzelepis GE. Respiratory function in patients with thalassaemia and iron overload. Eur Respir J 1999;13:602-605.
23. Olivieri NF, Brittenham G, Matsui D, Berkovitch M, Blendis LM, Cameron RG, McClelland RA, Liu PP, Templeton DM, Koren G. Iron-chelation therapy with oral deferiprone in patients with thalassemia major. N Engl J Med 1995;332:918-922.
24. Flatley FJ, Constantine H, McCredie RM, Yu PN. Pulmonary capillary blood volume in normal subjects and in cardiac patients. Am Heart J 1962;64:159-169.
25. Mollison PL. Blood transfusion in clinical medicine, 5th ed. Oxford: Blackwell Scientific; 1972.
26. Femi-Pearse D, Gazioglu KM, Yu PN. Pulmonary function studies in sickle cell disease. J Appl Physiol 1970;28:574-577.