Increased activity of eukaryotic initiation factor 2B in PC12 cells in response to differentiation by nerve growth factor

Journal of Neurochemistry

Volumn 71, Issue 5, 1998, Pages 1905-1911

  Munoz F ^a   Quevedo, C ^b   Martin M E ^a   Alcazar A ^b   Salinas, M ^b   Fando, J L ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Initiation factors 2 and 2B; Nerve growth factor; PC12 cell differentiation; Translation

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; NERVE GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

EID: 0042577160     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71051905.x     Document Type: Article

References (49)

1. Alcázar A., Martín M. E., Soria E., Rodríguez S., Fando J. L., and Salinas M. (1995) Purification and characterization of guanine nucleotide-exchange factor, eIF-2B, and p37 calmodulin-binding protein from calf brain. J. Neurochem. 65, 754-761.
2. Alcázar A., Rivera J., Gómez-Calcerrada M., Muñoz F., Salinas M., and Fando J. L. (1996) Changes in the phosphorylation of eukaryotic initiation factor 2α, initiation factor 2B activity and translational rates in primary neuronal cultures under diffrent physiological growing conditions. Mol. Brain Res. 38, 101-108.
3. Alcázar A., Martín de la Vega C., Bazán E., Fando J. L., and Salinas M. (1997) Calcium mobilization by ryanodine promotes the phosphorylation of initiation factor 2α subunit and inhibits protein synthesis in cultured neurons. J. Neurochem. 69, 1703-1708.
4. Aroor A. R., Denslow N. D., Singh L. P., O'Brien T. W., and Wahba A. J. (1994) Phosphorylation of rabbit reticulocyte guanine nucleotide exchange factor "in vivo." Identification of putative casein kinase II phosphorylation sites. Biochemistry 33, 3350-3357.
5. Aroor A. R., Singh L. P., and Wahba A. J. (1995) Hexamethylene bisacetamide-induced differentiation of Friend virus-transformed murine erythroleukemia cells is associated with parallel changes in casein kinase II and guanine nucleotide exchange factor activities. Exp. Hematol. 23, 1204-1211.
6. Boniece I. R. and Wagner J. A. (1993) Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC and protein synthesis. J. Neurosci. 13, 4220-4228.
7. Boniece I. R. and Wagner J. A. (1995) NGF protects PC12 cells against ischemia by a mechanism that requires the N-kinase. J. Neurosci. Res. 40, 1-9.
8. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
9. Burda J., Martín M. E., García A., Alcázar A., Fando J. L., and Salinas M. (1994) Phosphorylation of the α subunit of mutation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Biochem. J. 302, 335-338.
10. Burda J., Martín M. E., Gottlieb M., Chavko M., Marsala J., Alcázar A., Pavón M., Fando J. L., and Salinas M. (1998) The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2α kinase activity and role of initiation factors eIF-2α and eIF-4E. J. Cereb. Blood Flow Metab. 18, 59-66.
11. Carter A. N. and Downes C. P. (1992) Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J. Biol. Chem. 267, 14563-14567.
12. Cross D. A. E., Alessi D. R., Cohen P., Andjelkovich M., and Hemmings B. A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by PKB. Nature 378, 785-789.
13. Cross D. A. E., Watt P. W., Shaw M., van der Kaay J., Downes C. P., Holder J. C., and Cohen P. (1997) Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett. 406, 211-215.
14. DeGracia D. J., Neumar R. W., White B. C., and Krause G. S. (1996) Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation. J. Neurochem. 67, 2005-2012.
15. Dudek H., Datta S. R., Franke T. F., Birnbaum M. J., Yao R., Cooper G. M., Segal R. A., Kaplan D. R., and Greenberg M. E. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-664.
16. Duncan R. and Hershey J. W. B. (1985) Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. J. Biol. Chem. 260, 5493-5497.
17. Everson W. V., Flaim K. E., Susco D. M., Kimball S. R., and Jefferson L. S. (1989) Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. Am. J. Physiol. 256, C18-C27.
18. Fabian J. R., Kimball S. R., Heinzinger N. K., and Jefferson L. S. (1997) Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. J. Biol. Chem. 272, 12359-12365.
19. García A., Martín M. E., Alcázar A., Fando J. L., and Salinas M. (1996) Effect of diabetes on protein synthesis and eukaryotic initiation factor activities in the liver of virgin and pregnant rats. Biol. Neonate 69, 37-50.
20. Garrels J. I. and Schubert D. (1979) Modulation of protein synthesis by nerve growth factor. J. Biol. Chem. 254, 7978-7985.
21. Gilligan M., Welsh G. I., Flynn A., Bujalska I., Diggle T. A., Denton R. M., Proud C. G., and Docherty K. (1996) Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. J. Biol. Chem. 271, 2121-2125.
22. Greenberg M. E., Greene L. A., and Ziff E. B. (1985) Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J. Biol. Chem. 260, 14101-14110.
23. Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
24. Greene L. A., Sobeih M. M., and Teng K. K. (1991) Methodologies for the culture and experimental use of the PC12 rat pheochromocytoma cell line, in Culturing Nerve Cells (Banker G. and Goslin K., eds), pp. 207-226. MIT Press, Cambridge.
25. Halegoua S., Armstrong R., and Kremer N. (1991) Dissecting the mode of action of a neuronal growth factor. Curr. Top. Microbiol. Immunol. 165, 120-127.
26. Hondermark H., McLaughlin C. S., Patterson S. D., and Bradshaw R. A. (1994) Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 91, 9377-9381.
27. Kaplan D. R. and Miller F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 9, 213-221.
28. Kaplan D. R. and Stephens R. M. (1994) Neurotrophin signal transduction by the Trk receptor. J. Neurobiol. 25, 1404-1417.
29. Kaplan D. R., Martin-Zanca D., and Parada L. (1991) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.
30. Karinch A. M., Kimball S. R., Vary T. C., and Jefferson L. S. (1993) Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Am. J. Physiol. 264, E101-E108.
31. Kimball S. R., Karinch A. M., Feldhoff R. C., Mellor H., and Jefferson L. S. (1994) Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver. Biochim. Biophys. Acta 1201, 473-481.
32. Kimball S. R., Mellor H., Flowers K. M., and Jefferson L. S. (1996) Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells. Prog. Nucleic Acid Res. Mol. Biol. 54, 165-196.
33. Kimura K., Hattori S., Kabuyama Y., Shizawa Y., Takayanagi J., Nakamura S., Toki S., Matsuda Y., Onodera K., and Fukui Y. (1994) Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 18961-18967.
34. Klein R., Jing S., Nanduri V., O'Rourke E., and Barbacid M. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189-197.
35. Marshall C. J. (1995) Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
36. Martín M. E., Alcázar A., Fando J. L., García A., and Salinas M. (1993) Translational initiation factor eIF-2 subcellular levels and phosphorylation status in the developing rat brain. Neurosci. Lett. 156, 109-112.
37. Matts R. L., Levin D. H., and London I. M. (1983) Effect of phosphorylation of the α subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis. Proc. Natl. Acad. Sci. USA 80, 2559-2563.
38. Mesner P. W., Epting C. L., Hegarty J. L., and Green S. H. (1995) A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells. J. Neurosci. 15, 7357-7366.
39. Ochoa S. (1983) Regulation of protein synthesis initiation in eukaryotes. Arch. Biochem. Biophys. 223, 325-349.
40. Oldfield S. and Proud C. G. (1992) Purification, phosphorylation and control of the guanine-nucleotide-exchange factor from rabbit reticulocyte lysates. Eur. J. Biochem. 208, 73-81.
41. Pain V. M. (1996) Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236, 747-771.
42. 3 pituitary cells by perturbants of early protein processing that induce GRP78. J. Biol. Chem. 267, 16751-16754.
43. Proud C. G. (1992) Protein phosphorylation in translational control. Curr. Top. Cell Regul. 32, 243-369.
44. Rowlands A. G., Montine K. S., Henshaw E. C., and Panniers R. (1988) Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells. Eur. J. Biochem. 175, 93-99.
45. Rukenstein A., Rydel R. E., and Greene L. A. (1991) Multiple agents rescue PC12 cells from serum-free cell death by translation and transcription-independent mechanisms. J. Neurosci. 11, 2552-2563.
46. Scorsone K. A., Panniers R., Rowlands A. G., and Henshaw E. C. (1987) Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis. J. Biol. Chem. 262, 14538-14543.
47. Singh L. P., Denslow N. D., and Wahba A. J. (1996) Modulation of rabbit reticulocyte guanine nucleotide exchange factor activity by casein kinases 1 and 2 and glycogen synthase kinase 3. Biochemistry 35, 3206-3212.
48. Welsh G. I. and Proud C. G. (1992) Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors. Biochem. J. 284, 19-23.
49. Welsh G. I., Miyamoto S., Price N. T., Safer B., and Proud C. G. (1996) T-cell activation leads to rapid stimulation of translation initiation factor eIF-2B and inactivation of glycogen synthase kinase-3. J. Biol. Chem. 271, 11410-11413.