The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard

Military Medicine

Volumn 168, Issue 8, 2003, Pages 614-617

  Karayilanoǧlu, Turan ^a   Gunhan, Ömer ^b   Kenar, Levent ^b   Kurt, Bulent ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CHLORMETHINE; DEFEROXAMINE; ZINC CHLORIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HISTOPATHOLOGY; MALE; NONHUMAN; PUNCH BIOPSY; SKIN BIOPSY; SKIN PROTECTION; SKIN TOXICITY;

EID: 0042575616     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.1093/milmed/168.8.614     Document Type: Article

References (22)

1. Mershon MM, Mitcheltree LW, Petralji JP: Hairless guinea pig bioassay model for vesicant vapor exposures. Fundam Appl Toxicol 1990; 15: 622-30.
2. Karayilanoglu T: Medical effects of chemical, biological and nuclear warfare agents (in Turkish). Ankara, Turkey, GATA Publishing Department, 1996.
3. Wormser U, Brodsky B, Green BS: Protective effect of povidone-iodide oinment against skin lesions induced by sulfur and nitrogen mustard and nonmustard vesicant. Arch Toxicol 1997; 71: 165-70.
4. Smith W, Dunn MA: Medical defense against blistering chemical warfare agents. Arch Dermatol 1991; 127: 1207-13.
5. Papirmaister B, Clark LG, Meier HL: Molecular basis for mustard induced vesication. Fundam Appl Toxicol 1985; 5: 134-49.
6. Gold MB, Bonglavanni R, Scharf BA: Hypochloride solution as a decontaminant in sulphur mustard contaminated skin defects in the euthymic hairless guinea pig. Drug Chem Toxicol 1994; 17: 499-527.
7. Marijke AE, Rob De Vries, Andre W: Effects of nicotinamide on biochemical changes and microblistering induced by sulfur mustard in human skin organ cultures. Toxicol Appl Pharmacol 1991; 107: 439-49.
8. Knezevic DL, Tadic V, Cethovic SB: The efficiency of different formulations of protective-decontaminating oinments based on polyethylene glycol in rats percutaneously poisoned with highly toxic organophosphates. Vet Human Toxicol 1993; 35: 418-20.
9. Samsullah K, Jay JR, Peter JO: Hepatocyte toxicity of meclorethamine and other alkylating anticancer drugs. Biochem Pharmacol 1992; 43: 1963-7.
10. Peter G, Kate L, Andrew M: Modulation of mustard toxicity by tacrine. Biochem Pharmacol 1994; 47: 581-3.
11. Golderman GJ, Vanstone CL, Bihler I.: Transport of nitrogen mustard on the transport carrier for choline. Science 1971; 1148-9.
12. Vladimir V, Zorica M, Bogdan B: The protective effect of drugs in rats poisoned by sulfur and nitrogen mustards. Fundam Appl Toxicol 1985; 5: 160-8.
13. Gamesik MP, Hamill TG, Calvin M: NMR studies of the conjugation of meclorethamine with glutathion. J Med Chem 1990; 33: 1009-14.
14. Mol MA, Kluviers AW: Effects of induced by sulfur mustard in human skin organ cultures. Toxicol Appl Pharmacol 1991; 107: 439-49.
15. Sawyer TW, Deborah P, Norleen T: Efficacy of an oximate-based decontaminant against organophosphate nerve agents determined in vivo and in vitro. Toxicology 1991; 67: 267-77.
16. Momeni A, Enshaeih SM: Skin manifestations of mustard gas. Arch Dermatol 1992; 128: 775-80.
17. Scheidegger D, Sparkers BG, Lusher N: Survival in major burn injuries treated by one bathing in cerium nitrate. Burns 1992; 18: 296-300.
18. Thomes WS, Hancock JR: L-Thiocitrulline: a potent protective agent against the toxicity of sulphur mustard in vitro. Toxicol Appl Pharmacol 1998; 151: 340-6.
19. 1 mice. J Appl Toxicol 1992; 12: 295-300.
20. Davies MJ, Donkor R, Dunster C: Desferrioxamine and superoxide radicals. Biochem J 1987; 246: 725-9.
21. Halliwell B: Protection against tissue damage in vivo by desferrioxamine. Free Radic Biol Med 1989; 7: 645-61.
22. Ben-Zhan-Zhu, Har-el R, Kitrossky N, Chevion M: New modes of desferrioxamine. Free Radic Biol Med 1998; 24: 360-9.