Hypersomnia and low CSF hypocretin-1 (orexin-A) concentration in a patient with multiple sclerosis showing bilateral hypothalamic lesions

Internal Medicine

Volumn 42, Issue 8, 2003, Pages 743-745

  Kato, Takashi ^a,c   Kanbayashi, Takashi ^b   Yamamoto, Kanji ^a,c   Nakano, Takeshi ^a,c   Shimizu, Tetsuo ^b   Hashimoto, Takao ^c   Ikeda, Shu Ichi ^c  

^a Toyoshina Red Cross Hospital   (Japan)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hypersomnia; Hypocrein; Hypothalamus; Multiple sclerosis; Orexin

Indexed keywords

IMMUNOGLOBULIN; METHYLPREDNISOLONE; OREXIN A;

ADULT; ARM DISEASE; AROUSAL; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CONCENTRATION RESPONSE; DRUG PULSE THERAPY; ELECTROENCEPHALOGRAPHY; FEMALE; GAZE PARALYSIS; HUMAN; HYPERSOMNIA; HYPOTHALAMUS LESION; IMMUNOADSORPTION; JAPAN; MULTIPLE SCLEROSIS; MUSCLE WEAKNESS; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OPHTHALMOPLEGIA; POLYSOMNOGRAPHY; RADIOIMMUNOASSAY; RELAPSE; TREATMENT OUTCOME; URINE INCONTINENCE;

EID: 0042536501     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.42.743     Document Type: Article

References (13)

1. de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Pro Natl Acad Sci USA 95: 322-327, 1998.
2. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585, 1998.
3. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24: 726-731, 2001.
4. Nishino S, Ripley B, Overeem S, et al. Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 50: 381-388, 2001.
5. Scammell TE, Nishino S, Mignot E, Saper CB. Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke. Neurology 56: 1751-1753, 2001.
6. Arii J, Kanbayashi T, Tanabe Y, Ono J, Nishino S, Kohno Y. A hypersomnolent girl with decreased CSF hypocretin level after removal of a hypothalamic tumor. Neurology 56: 1775-1776, 2001.
7. Miller JR. Multiple Sclerosis. In: Merritt's Neurology 10th ed. Rowland LP ed. Lippincott Williams & Wilkins, Philadelphia, 2000: 773-792.
8. Poirier G, Montplaisir J, Dumont M, et al. Clinical and sleep laboratory study of narcoleptic symptoms in multiple sclerosis. Neurology 37: 693-695, 1987.
9. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 50: 121-127, 2001.
10. Kanbayashi T, Yano T, Ishiguro H, et al. Hypocretin-1 (Orexin-A) levels in human lumbar CSF in different age groups: infants to elderly persons. Sleep 25: 337-339, 2002.
11. Huitinga I, De Groot CJA, von der Valk P, Kamphorst W, Tilders FJ, Swaab DF. Hypothalamic lesions in multiple sclerosis. J Neuropathol Exp Neurol 60: 1208-1218, 2001.
12. Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knock-out mice: molecular genetics of sleep regulation. Cell 98: 437-451, 1999.
13. Lin L, Faraco J, Li R, et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-376, 1999.