Humane and Practical Implications of Using Carbon Dioxide Mixed with Oxygen for Anesthesia or Euthanasia of Rats

Laboratory Animal Science

Volumn 47, Issue 4, 1997, Pages 376-385

  Danneman, Peggy J ^a,c   Stein, Susan ^b   Walshaw, Sally O ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL WELFARE; ARTICLE; CARBON DIOXIDE BREATHING; CAUSE OF DEATH; EDEMA; EPISTAXIS; EUTHANASIA; NONHUMAN; RAT; SEIZURE;

ADULT; ANESTHESIA, INHALATION; ANESTHETICS, COMBINED; ANIMAL WELFARE; ANIMALS; CARBON DIOXIDE; EUTHANASIA; FEMALE; HEMORRHAGE; HUMANS; LUNG DISEASES; MALE; MIDDLE AGED; OXYGEN; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SENSATION;

EID: 0031400070     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. AVMAPanel on Euthanasia. 1993, 1993 Report of the AVMA Panel on Euthanasia. J. Am. Vet. Med. Assoc. 202:230-249.
2. Canadian Council on Animal Care. 1993. Euthanasia, p. 141-153. In E. D. Olfert, B. M. Cross, and A. A. McWilliam (ed.), Guide to the care and use of experimental animals, vol. 1. Canadian Council on Animal Care, Ottawa, Canada.
3. Clifford, D. H. 1984. Preanesthesia, anesthesia, analgesia, and euthanasia, p. 527-562. In J. G. Fox, B. J. Cohen, and F. M. Loew (ed.), Laboratory animal medicine. Academic Press, Inc., Orlando, Fla.
4. National Research Council. 1992. Euthanasia, p. 102-116. In Recognition and alleviation of pain and distress in laboratory animals. A report of the Institute of Laboratory Animal Resources Committee on Pain and Distress in Laboratory Animals, National Research Council, National Academy of Sciences. National Academy Press, Washington, D.C.
5. Britt, D. P. 1993. The humaneness of carbon dioxide as an agent of euthanasia for laboratory rodents, p. 19-31. In Euthanasia of unwanted, injured or diseased animals or for educational or scientific purposes, UFAW.
6. Raj, M., and N. G. Gregory. 1994. An evaluation of humane gas stunning methods for turkeys. Vet. Rec. Sept 3:222-223.
7. 2 pulses applied to the nasal mucosa. Pain 49:53-60.
8. Cain, W. S., and C. L. Murphy. 1980. Interaction between chemoreceptive modalities of odor and irritation. Nature 284:255-257.
9. Kobal, G. 1985. Pain-related electrical potentials of the human nasal mucosa by chemical stimulation. Pain 22:151-163.
10. Kobal, G., C. Hummel, M. Gruber, et al. 1994. Dose-related effects of ibuprofen on pain-related potentials. Br. J. Clin. Pharmacol. 37:445-452.
11. Stevens, J. C., and W. S. Cain. 1986. Aging and the perception of nasal irritation. Physiol. Behav. 37:323-328.
12. 2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. Br. J. Clin. Pharmacol. 38:545-555.
13. Komai, M., and B. P. Bryant. 1993. Acetazolamide specifically inhibits lingual trigeminal nerve responses to carbon dioxide. Brain Res. 612:122-129.
14. Peppel, P., and F. Anton. 1993. Responses of rat medullary dorsal horn neurons following intranasal noxious chemical stimulation: effects of stimulus intensity, duration, and interstimulus interval. J. Neurophysiol. 70:2260-2275.
15. 2 in rats: is it a peripheral nociceptive event? Neurosci. Lett. 128:297-300.
16. Berger-Sweeney, J., U. V. Berger, M. Sharma, et al. 1994. Effects of carbon dioxide-induced anesthesia on cholinergic parameters in rat brain. Lab. Anim. Sci. 44:369-371.
17. Blackshaw, J. K., D. C. Fenwick, A. W. Beattie, et al. 1988. The behavior of chickens, mice and rats during euthanasia with chloroform, carbon dioxide and ether. Lab. Animals 22:67-75.
18. Bowyer, G., and S. Cubitt. 1995. An improved method of carbon dioxide euthanasia for rodents. Anim. Technol. 46:19-28.
19. Hewett, T. A., M. S. Kovacs, J. E. Artwohl, et al. 1993. A comparison of euthanasia methods in rats, using carbon dioxide in prefilled and fixed low rate filled chambers. Lab. Anim. Sci. 43:579-582.
20. Urbanski, H. F., and S. T. Kelley. 1991. Sedation by exposure to a gaseous carbon dioxide-oxygen mixture: application to studies involving small laboratory animal species. Lab. Anim. Sci. 41:80-81.
21. Cauna, N., K. H. Hinderer, and R. T. Wentges. 1969. Sensory receptor organs of the human nasal respiratory mucosa. Am. J. Anat. 124:187-210.
22. Public Health Service. 1986. Public Health Service Policy on Humane Care and Use of Laboratory Animals. U.S. Department of Health and Human Services, Washington, D.C.
23. Code of Federal Regulations. 1992. Title 9: Animals and animal products, subchapter A, animal welfare, part 1.
24. Hummel, T., M. Gruber, E. Pauli, et al. 1994. Chemosomatosensory event-related potentials in response to repetitive painful chemical stimulation of the nasal mucosa. Electroencephalogr. Clin. Neurophysiol. 92:426-432.
25. Steen, K. H., P. W. Reeh, F. Anton, et al. 1992. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J. Neurosci. 12:86-95.
26. Medina, M. R. G., and W. S. Cain. 1982. Bilateral integration in the common chemical sense. Physiol. Behav. 29:349-353.
27. Eisele, J. H., E. I. Eger II, and M. Muallem. 1967. Narcotic properties of carbon dioxide in the dog. Anesthesiology 28:856-865.
28. Mattsson, J. L., J. M. Stinson, and C. S. Clark. 1973. Electroencephalographic power-spectral changes coincident with onset of carbon dioxide narcosis in rhesus monkey. Am. J. Vet. Res. 33:2043-2049.
29. Woodbury, D. M., L. T. Rollins, M. D. Gardner, et al. 1958. Effects of carbon dioxide on brain excitability and electrolytes. Am. J. Physiol. 192:79-90.
30. Klemm, W. R. 1964. Carbon dioxide anesthesia in cats. Am. J. Vet. Res. 25:1201-1205.
31. 2 tension and neuronal excitability. J. Physiol. 176:105-122.
32. Woodbury, D. M., and R. Karler. 1960. The role of carbon dioxide in the nervous system. Anesthesiology 21:686-703.
33. Gronroos, M., and A. Pertovaara. 1994. A selective suppression of human pain sensitivity by carbon dioxide: central mechanisms involved. Eur. J. Appl. Physiol. 68:74-79.
34. Nunn, J. F. 1987. The effects of changes in the carbon dioxide tension, p. 460-471. In Applied respiratory physiology. Butterworths & Co., Ltd., London.
35. Thom, S. R., and J. M. Clark. 1990. The toxicity of oxygen, carbon monoxide, and carbon dioxide, p. 82-94. In A. A. Bove and J. C. Davis (ed.), Diving medicine. The W. B. Saunders Co., Philadelphia.
36. 2 euthanasia. Nature (Letter.) 304:482.
37. AGA Gas, Inc. 1985. Material safety data sheet: carbon dioxide. 1-3. AGA Gas, Inc., Cleveland, Ohio.
38. Ganong, W. F. 1983. Respiratory adjustments in health & disease, p. 549-562. In Anonymous (ed.), Review of medical physiology. Lange Medical Publications, Los Altos, Calif.
39. Coenen, A. M. L., W. H. I. M. Drinkenburg, R. Hoenderken, et al. 1995. Carbon dioxide euthanasia in rats: oxygen supplementation minimizes signs of agitation and asphyxia. Lab. Animals 29:262-268.
40. Brodie, D. A., and D. M. Woodbury. 1958. Acid-base changes in brain and blood of rats exposed to high concentrations of carbon dioxide. Am. J. Physiol. 192:91-94.
41. 2 narcosis in the rat. I. Effects on respiration and blood parameters. Aerospace Med. 42:547-552.
42. Nunn, J. F. 1987. Hyperoxia and oxygen toxicity. Chap. 29. In Applied respiratory physiology. Butterworths & Co., Ltd., London.
43. Fawell, J. K., C. Thomson, and L. Cooke. 1972. Respiratory artefact produced by carbon dioxide and pentobarbitone sodium euthanasia in rats. Lab. Animals 6:321-326.
44. Robl, M. G. 1996. Personal communication.
45. Maron, M. B., P. H. Holcomb, C. A. Dawson, et al. 1994. Edema development and recovery in neurogenic pulmonary edema. J. Appl. Physiol. 77:1155-1163.
46. 2 changes in normal humans. J. Trauma 39:463-472.
47. Liem, K. D., A. A. Kollee, J. C. W. Hopman, et al. 1995. The influence of arterial carbon dioxide on cerebral oxygenation and hemodynamics during ECMO in normoxemic and hypoxemic piglets. Acta Anaesthesiol. Scand. 39 (Suppl. 107): 157-164.
48. Mischler, S. A., M. Alexander, A. H. Battles, et al. 1994. Prolonged antinociception following carbon dioxide anesthesia in the laboratory rat. Brain Res. 640:322-327.