Does hepatomegaly alter iron-dependent oxidative effects in human plasma?

Human and Experimental Toxicology

Volumn 22, Issue 7, 2003, Pages 401-405

  Galleano, Monica ^a   Lemberg, Abraham ^a   Puntarulo, Susana ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Hepatomegaly; Human plasma; Iron overload; Oxidative damage

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; IRON; IRON DEXTRAN; IRON SORBITEX; THIOBARBITURIC ACID REACTIVE SUBSTANCE; YECTAFER;

ARTICLE; BLOOD SAMPLING; CASE REPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RESPONSE; ELECTROCHEMICAL ANALYSIS; FLUOROMETRY; HEART FAILURE; HEPATOMEGALY; HUMAN; IRON BLOOD LEVEL; IRON OVERLOAD; IRON THERAPY; LIPID PEROXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VITAMIN BLOOD LEVEL;

CITRIC ACID; DRUG COMBINATIONS; FERRIC COMPOUNDS; HEPATOMEGALY; HUMANS; INJECTIONS, INTRAMUSCULAR; LIPID PEROXIDATION; LIVER; OXIDATIVE STRESS; SORBITOL; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0042524630     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Fraga CG, Oteiza PI. Iron toxicity and antioxidant nutrients. Toxicology 2002; 180: 23-32.
2. Rasmussen M, Folsom AR, Catellier DJ, Tsai MY, Garg U, Eckfeldt JH. A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the atherosclerosis risk in communities (ARIC) study. Atherosclerosis 2001; 154: 739-46.
3. Milman N, Pedersen P, Steig T, Byg KE, Graudal N, Fenger K. Clinical overt hereditary hemochromatosis in Denmark 1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients. Ann Hematol 2001; 80: 737-44.
4. Yang Q, McDonnell SM, Khoury MJ, Cono J, Parrish RG. Hemochromatosis-associated mortality in the United States from 1979 to 1992: an analysis of Multiple-Cause Mortality Data. Ann Intern Med 1998; 129: 946-53.
5. Tenenbein M. Hepatotoxicity in acute iron poisoning. J Toxicol Clin Toxicol 2001; 39: 721-26.
6. Burns DL, Mascioli EA, Bistrian BR. Parenteral iron dextran therapy: a review. Nutrition 1995; 11: 163-68.
7. Turnlund JR, Smith RG, Kretsch MJ, Keyes WR, Shah AG. Milk's effect on the bioavailability of iron from cereal-based diets in young women by use of in vitro and in vivo methods. Am J Clin Nutr 1990; 52: 373-78.
8. Gutteridge JMC, Quinlan GJ. Antioxidant protection against organic and inorganic oxgygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins. Biochim Biophys Acta 1992; 1159: 248-54.
9. Rooyakkers TM, Stroes ES, Kooistra MP, van Faassen EE, Hiden RC, Rabelink TJ, Marx JJ. Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo. Eur J Clin Invest 2002; 32 (Suppl 1): 9-16.
10. Persjin JP, van der Slik W, Riethorst A. A determination of serum iron and latent iron-binding capacity (LIBC). Clin Chim Acta 1971; 35: 91-98.
11. Fraga CG, Leibovitz BE, Tappel AL. Halogenated compounds as inducers of lipid peroxidation in tissue slices. Free Radic Biol Med 1987; 3: 119-23.
12. Lang JK, Gohil K, Packer L. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem 1986; 157: 106-16.
13. Galleano M, Puntarulo S. Hepatic chemiluminescence and lipid peroxidation in mild iron overload. Toxicology 1992; 76: 27-38.
14. Tapia G, Troncoso P, Galleano M, Fernandez V, Puntarulo S. Videla LA. Time course study of the influence of acute iron overload on Kupffer cell functioning and hepatotoxicity assessed in the isolated perfused rat liver. Hepatology 1998; 27: 1311-16.
15. Stocker R, Frei B. Endogenous antioxidant defenses in human blood plasma. In Sies H ed. Oxidants and antioxidants. San Diego: Academic Press, 1991: 213-37.
16. Saran M, Bors W. Oxygen radicals acting as chemical messengers: a hypothesis. Free Radic Res Comm 1989; 7: 213-20.
17. Stocks J, Gutteridge JMC, Sharp RJ, Dormandy TL. The inhibition of lipid autoxidation in human serum and its relation to serum proteins and alpha-tocopherol. Clin Sci Mol Med 1974; 47: 223-33.
18. Gutteridge JMC. Reduction of low molecular mass iron by reducing molecules present in plasma and the protective action of caeruloplasmin. J Trace Elem Electrol Health Dis 1991; 5: 279-81.