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Volumn 13, Issue 2, 2003, Pages 108-117

Immunotherapy with a depigmented, polymerized vaccine of Olea europaea pollen allergens: Significantly reduces specific bronchial and skin test reactivity in sensitized patients after one year of treatment

Author keywords

Allergen vaccine; Bronchial provocation; Clinical efficacy; Immunotherapy; Olea europaea

Indexed keywords

ANTIHISTAMINIC AGENT; BUDESONIDE; CORTICOSTEROID; GLUTARALDEHYDE; POLLEN ANTIGEN; POLLEN EXTRACT; SALBUTAMOL; VACCINE;

EID: 0042510918     PISSN: 10189068     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (46)
  • 1
    • 0024511747 scopus 로고
    • Safety and immunogenicity of immunotherapy with accelerated dosage schedules of polymerized grass and ragweed in patients with dual inhalant sensitivity
    • Grammer, L.C., Shaughnessy, M.A., Shaughnessy, J.J., Patterson, R. Safety and immunogenicity of immunotherapy with accelerated dosage schedules of polymerized grass and ragweed in patients with dual inhalant sensitivity. J Allergy Clin Immunol 1989, 83(4):750-756.
    • (1989) J Allergy Clin Immunol , vol.83 , Issue.4 , pp. 750-756
    • Grammer, L.C.1    Shaughnessy, M.A.2    Shaughnessy, J.J.3    Patterson, R.4
  • 2
    • 0021071348 scopus 로고
    • A double-blind histamine placebo-controlled trial of polymerized whole grass for immunotherapy of grass allergy
    • Grammer, L.C., Shaughnessy, M.A., Suszko, I.M., Shaughnessy, J.J., Patterson, R. A double-blind histamine placebo-controlled trial of polymerized whole grass for immunotherapy of grass allergy. J Allergy Clin Immunol 1983, 72(5 Pt 1):448-453.
    • (1983) J Allergy Clin Immunol , vol.72 , Issue.5 PART 1 , pp. 448-453
    • Grammer, L.C.1    Shaughnessy, M.A.2    Suszko, I.M.3    Shaughnessy, J.J.4    Patterson, R.5
  • 3
    • 0022873487 scopus 로고
    • A double-blind placebo-controlled trial of polymerized whole grass administered in an accelerated dosage schedule for immunotherapy of grass pollinosis
    • Grammer, L.C., Shaughnessy, M.A., Finkle, S.M., Shaughnessy, J.J., Patterson, R. A double-blind placebo-controlled trial of polymerized whole grass administered in an accelerated dosage schedule for immunotherapy of grass pollinosis. J Allergy Clin Immunol 1986, 78(6):1180-1184.
    • (1986) J Allergy Clin Immunol , vol.78 , Issue.6 , pp. 1180-1184
    • Grammer, L.C.1    Shaughnessy, M.A.2    Finkle, S.M.3    Shaughnessy, J.J.4    Patterson, R.5
  • 5
    • 0027972617 scopus 로고
    • Safety considerations in assessing the role of immunotherapy in allergic disorders
    • Bousquet, J., Michel, F.B. Safety considerations in assessing the role of immunotherapy in allergic disorders. Drug Saf 1994, 10(1):5-17.
    • (1994) Drug Saf , vol.10 , Issue.1 , pp. 5-17
    • Bousquet, J.1    Michel, F.B.2
  • 6
    • 0005183687 scopus 로고    scopus 로고
    • Complexed flavonoids on pollen protein allergens revealed by uv-spectroscopy and thin-layer chromatography
    • Berrens, L., Gallego, M.T., Boluda, L., Fernández-Caldas, E., González, L. Complexed flavonoids on pollen protein allergens revealed by uv-spectroscopy and thin-layer chromatography. Allergy 1998, 53(suppl):56.
    • (1998) Allergy , vol.53 , Issue.SUPPL. , pp. 56
    • Berrens, L.1    Gallego, M.T.2    Boluda, L.3    Fernández-Caldas, E.4    González, L.5
  • 8
    • 0027292170 scopus 로고
    • Linear monitoring of patients sensitive to Olea and grass pollens treated with immunotherapy based on glutaraldehyde-modified (allergoid) extracts
    • Guerra, F., Moreno, C., Daza, J.C., Miguel, R., Garcia, M., Sanchez Guijo, P. Linear monitoring of patients sensitive to Olea and grass pollens treated with immunotherapy based on glutaraldehyde-modified (allergoid) extracts. J Invest Allergol Clin Immunol 1993, 3(4):182-190.
    • (1993) J Invest Allergol Clin Immunol , vol.3 , Issue.4 , pp. 182-190
    • Guerra, F.1    Moreno, C.2    Daza, J.C.3    Miguel, R.4    Garcia, M.5    Sanchez Guijo, P.6
  • 9
    • 0041675936 scopus 로고
    • Prepared by the Nordic Council on Medicines in cooperation with the Drug Regulatory Authorities in Denmark, Finland, Iceland, Norway and Sweden. NLN Publication No. 23; Edn. January (Chapter 5, Clinical Documentation)
    • Nordic Council on Medicines. Registration of allergen preparations. Nordic-guidelines. Prepared by the Nordic Council on Medicines in cooperation with the Drug Regulatory Authorities in Denmark, Finland, Iceland, Norway and Sweden. NLN Publication No. 23 1989; Edn. January (Chapter 5, Clinical Documentation), p. 21.
    • (1989) Registration of Allergen Preparations. Nordic-Guidelines , pp. 21
  • 10
    • 0031817107 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases. A WHO position paper
    • Bousquet, J., Lockey, R., Malling, H.J. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. Allergy 1998, 53(suppl):1-42.
    • (1998) Allergy , vol.53 , Issue.SUPPL. , pp. 1-42
    • Bousquet, J.1    Lockey, R.2    Malling, H.J.3
  • 11
    • 0027360757 scopus 로고
    • Position paper: Allergen standardization and skin tests
    • The European Academy of Allergology and Clinical Immunology
    • EAACI. Position paper: Allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology. Allergy 1993, 48(14 suppl):48-82.
    • (1993) Allergy , vol.48 , Issue.14 SUPPL. , pp. 48-82
  • 12
    • 0041675938 scopus 로고
    • Prepared by the Nordic Council on Medicines in cooperation with the Drug Regulatory Authorities in Denmark, Finland, Iceland, Norway and Sweden. NLN Publication No. 23; Edn. January (Chapter 5, Clinical Documentation)
    • Nordic Council on Medicines. Registration of allergen preparations. Nordic-guidelines. Prepared by the Nordic Council on Medicines in cooperation with the Drug Regulatory Authorities in Denmark, Finland, Iceland, Norway and Sweden. NLN Publication No. 23 1989; Edn. January (Chapter 5, Clinical Documentation), p. 25-34.
    • (1989) Registration of Allergen Preparations. Nordic-Guidelines , pp. 25-34
  • 13
    • 0017654803 scopus 로고
    • Bronchial reactivity to inhaled histamine: A method and clinical survey
    • Cockcroft, D.W., Killian, D.N., Mellon, J.J., Hargreave, F.E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977, 7(3):235-243.
    • (1977) Clin Allergy , vol.7 , Issue.3 , pp. 235-243
    • Cockcroft, D.W.1    Killian, D.N.2    Mellon, J.J.3    Hargreave, F.E.4
  • 14
    • 0029920592 scopus 로고    scopus 로고
    • Bronchial allergen challenge methodological studies
    • Frolund, L. Bronchial allergen challenge methodological studies. Allergy 1996, 51(29 suppl):1-41.
    • (1996) Allergy , vol.51 , Issue.29 SUPPL. , pp. 1-41
    • Frolund, L.1
  • 15
    • 0019503240 scopus 로고
    • Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: Evidence for altered arachidonic acid metabolism in asthma
    • Fish, J.E., Ankin, M.G., Adkinson, N.F., Peterman, V.I. Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma. Am Rev Respir Dis 1981, 123(6):609-614.
    • (1981) Am Rev Respir Dis , vol.123 , Issue.6 , pp. 609-614
    • Fish, J.E.1    Ankin, M.G.2    Adkinson, N.F.3    Peterman, V.I.4
  • 16
    • 0017849050 scopus 로고
    • A comparison of the protective effect of fenoterol and Sch 1000 on allergen-induced asthma
    • Ruffin, R.E., Cockcroft, D.W., Hargreave, F.E. A comparison of the protective effect of fenoterol and Sch 1000 on allergen-induced asthma. J Allergy Clin Immunol 1978, 61(1):42-47.
    • (1978) J Allergy Clin Immunol , vol.61 , Issue.1 , pp. 42-47
    • Ruffin, R.E.1    Cockcroft, D.W.2    Hargreave, F.E.3
  • 17
    • 0023607936 scopus 로고
    • Allergen bronchial challenge tests: Variability and reproducibility of the early response
    • Kopferschmitt-Kubler, M.C., Bigot, H., Pauli, G. Allergen bronchial challenge tests: variability and reproducibility of the early response. J Allergy Clin Immunol 1987, 80(5):730-740.
    • (1987) J Allergy Clin Immunol , vol.80 , Issue.5 , pp. 730-740
    • Kopferschmitt-Kubler, M.C.1    Bigot, H.2    Pauli, G.3
  • 18
    • 0024317108 scopus 로고
    • Allergy to pollen grains from Amaranthaceae and Chenopodiaceae in Cordoba, Spain. Annual and daily variation of pollen concentration
    • Galan, C., Infante, F., Ruiz de Clavijo, E., Guerra, F., Miguel, R., Dominguez, E. Allergy to pollen grains from Amaranthaceae and Chenopodiaceae in Cordoba, Spain. Annual and daily variation of pollen concentration. Ann Allergy 1989, 63(5):435-438.
    • (1989) Ann Allergy , vol.63 , Issue.5 , pp. 435-438
    • Galan, C.1    Infante, F.2    Ruiz de Clavijo, E.3    Guerra, F.4    Miguel, R.5    Dominguez, E.6
  • 19
    • 0043178824 scopus 로고    scopus 로고
    • Nuevos aspectos de la aerobiología de los pólenes. Oleáceas
    • C. Colás, J. Fraj, A. Lezaun (Eds.). Debates sobre Alergología. Formigal, Febrero. Dep. Legal B-363112-362000
    • Feo Brito, F., Martínez, C., Gómez, E., Galindo, P.A., Borja, J., Mur, P. Nuevos aspectos de la aerobiología de los pólenes. Oleáceas. In C. Colás, J. Fraj, A. Lezaun (Eds.), Alergoaragón. Debates sobre Alergología. Formigal, Febrero 2000, p. 35-41. Dep. Legal B-363112-2000.
    • (2000) Alergoaragón , pp. 35-41
    • Feo Brito, F.1    Martínez, C.2    Gómez, E.3    Galindo, P.A.4    Borja, J.5    Mur, P.6
  • 20
    • 0022481799 scopus 로고
    • Adouble-blind, multicenter immunotherapy trial in children, using a purified and standardized Cladosporium herbarum preparation. I. Clinical results
    • Dreborg, S., Agrell, B., Foucard, T., Kjellman, N.I., Koivikko, A., Nilsson, S. Adouble-blind, multicenter immunotherapy trial in children, using a purified and standardized Cladosporium herbarum preparation. I. Clinical results. Allergy 1986, 41(2):131-140.
    • (1986) Allergy , vol.41 , Issue.2 , pp. 131-140
    • Dreborg, S.1    Agrell, B.2    Foucard, T.3    Kjellman, N.I.4    Koivikko, A.5    Nilsson, S.6
  • 21
    • 0015884673 scopus 로고
    • Polymerized ragweed antigen e. II. In vivo elimination studies and reactivity with IgE antibody systems
    • Patterson, R., Suszko, I.M., Pruzansky, J.J., Zeiss, C.R. Polymerized ragweed antigen e. II. in vivo elimination studies and reactivity with IgE antibody systems. J Immunol 1973, 110(5):1413-1418.
    • (1973) J Immunol , vol.110 , Issue.5 , pp. 1413-1418
    • Patterson, R.1    Suszko, I.M.2    Pruzansky, J.J.3    Zeiss, C.R.4
  • 22
    • 0015787634 scopus 로고
    • Polymerized ragweed antigen E. I. Preparation and immunologic studies
    • Patterson, R., Suszko, I.M., McIntire, F.C. Polymerized ragweed antigen E. I. Preparation and immunologic studies. J Immunol 1973, 110(5):1402-1412.
    • (1973) J Immunol , vol.110 , Issue.5 , pp. 1402-1412
    • Patterson, R.1    Suszko, I.M.2    McIntire, F.C.3
  • 23
    • 0014795815 scopus 로고
    • The use of glutaraldehyde as a coupling agent for ribonuclease and bovine serum albumin
    • Sachs, D.H., Winn, H.J. The use of glutaraldehyde as a coupling agent for ribonuclease and bovine serum albumin. Immunochemistry 1970, 7(6):581-585.
    • (1970) Immunochemistry , vol.7 , Issue.6 , pp. 581-585
    • Sachs, D.H.1    Winn, H.J.2
  • 24
    • 0033018461 scopus 로고    scopus 로고
    • Determination of Ole e 1 by enzyme immunoassay and scanning densitometry. Validation by skin-prick testing
    • Boluda, L., Sastre, J., Casanovas, M., Fernandez-Caldas, E. Determination of Ole e 1 by enzyme immunoassay and scanning densitometry. Validation by skin-prick testing. J Immunol Methods 1999, 223(1):17-26.
    • (1999) J Immunol Methods , vol.223 , Issue.1 , pp. 17-26
    • Boluda, L.1    Sastre, J.2    Casanovas, M.3    Fernandez-Caldas, E.4
  • 26
    • 0028308082 scopus 로고
    • Comparison of skin-prick test assay and reverse enzyme immunoassay competition (REINA-C) for biological activity of allergens
    • Casanovas, M., Maranon, F., Bel, I. Comparison of skin-prick test assay and reverse enzyme immunoassay competition (REINA-C) for biological activity of allergens. Clin Exp Allergy 1994, 24(2):134-139.
    • (1994) Clin Exp Allergy , vol.24 , Issue.2 , pp. 134-139
    • Casanovas, M.1    Maranon, F.2    Bel, I.3
  • 27
    • 0028335974 scopus 로고
    • Evaluation of the potency of allergenic extracts by inhibition of IgG-antibody binding
    • Boluda, L., Gallego, M.T., Gonzalez-Romano, M.L., Cambra, O., Berrens, L. Evaluation of the potency of allergenic extracts by inhibition of IgG-antibody binding. Biologicals 1994, 22(2):171-177.
    • (1994) Biologicals , vol.22 , Issue.2 , pp. 171-177
    • Boluda, L.1    Gallego, M.T.2    Gonzalez-Romano, M.L.3    Cambra, O.4    Berrens, L.5
  • 28
    • 0027214706 scopus 로고
    • Position paper: Immunotherapy
    • (EAACI) The European Academy of Allergology and Clinical Immunology
    • Immunotherapy Subcommittee E. Position paper: Immunotherapy. (EAACI) The European Academy of Allergology and Clinical Immunology. Allergy 1993, 48(14 suppl):7-35.
    • (1993) Allergy , vol.48 , Issue.14 SUPPL. , pp. 7-35
  • 29
    • 0025019270 scopus 로고
    • Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. IV. Comparison of the safety and efficacy of two dosages of a high-molecular-weight allergoid
    • Bousquet, J., Hejjaoui, A., Soussana, M., Michel, F.B. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. IV. Comparison of the safety and efficacy of two dosages of a high-molecular-weight allergoid. J Allergy Clin Immunol 1990, 85(2):490-497.
    • (1990) J Allergy Clin Immunol , vol.85 , Issue.2 , pp. 490-497
    • Bousquet, J.1    Hejjaoui, A.2    Soussana, M.3    Michel, F.B.4
  • 31
    • 0003741993 scopus 로고
    • The first step: Understanding simple linear regression
    • S.A. Glanz, B.K. Slinker (Eds.). New York: McGraw-Hill
    • Glanz, S.A., Slinker, B.K. The first step: understanding simple linear regression. In S.A. Glanz, B.K. Slinker (Eds.), Primer of applied regression and analysis of variance. New York: McGraw-Hill 1990, p. 27-35.
    • (1990) Primer of Applied Regression and Analysis of Variance , pp. 27-35
    • Glanz, S.A.1    Slinker, B.K.2
  • 32
    • 0036212321 scopus 로고    scopus 로고
    • The safety and efficacy of subcutaneous birch pollen immunotherapy - A one-year, randomised, double-blind, placebo-controlled study
    • Bodtger, U., Poulsen, L.K., Jacobi, H.H., Malling, H.J. The safety and efficacy of subcutaneous birch pollen immunotherapy - a one-year, randomised, double-blind, placebo-controlled study. Allergy 2002, 57(4):297-305.
    • (2002) Allergy , vol.57 , Issue.4 , pp. 297-305
    • Bodtger, U.1    Poulsen, L.K.2    Jacobi, H.H.3    Malling, H.J.4
  • 33
    • 0035139434 scopus 로고    scopus 로고
    • Grass pollen immunotherapy for seasonal rhinitis and asthma: A randomized, controlled trial
    • Walker, S.M., Pajno, G.B., Lima, M.T., Wilson, D.R., Durham, S.R. Grass pollen immunotherapy for seasonal rhinitis and asthma: a randomized, controlled trial. J Allergy Clin Immunol 2001, 107(1):87-93.
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.1 , pp. 87-93
    • Walker, S.M.1    Pajno, G.B.2    Lima, M.T.3    Wilson, D.R.4    Durham, S.R.5
  • 34
    • 0043178823 scopus 로고
    • Comparison of slopes and testing for linearity: Determination of the relative potency
    • S. Bolton (Ed.). New York: Marcel Decker
    • Bolton, S. Comparison of slopes and testing for linearity: Determination of the relative potency. In S. Bolton (Ed.), Pharmaceutical statistics. New York: Marcel Decker 1990, p. 575-582.
    • (1990) Pharmaceutical Statistics , pp. 575-582
    • Bolton, S.1
  • 35
    • 0016652420 scopus 로고
    • Relative sensitivity of different pulmonary function tests in the evaluation of exercise-induced asthma
    • Cropp, G.J. Relative sensitivity of different pulmonary function tests in the evaluation of exercise-induced asthma. Pediatrics 1975, 56(5 pt-2 suppl):860-867.
    • (1975) Pediatrics , vol.56 , Issue.5 PART 2 SUPPL. , pp. 860-867
    • Cropp, G.J.1
  • 36
    • 0018629569 scopus 로고
    • Measurements of responsiveness in bronchoprovocation testing
    • Fish, J.E., Kelly, J.F. Measurements of responsiveness in bronchoprovocation testing. J Allergy Clin Immunol 1979, 64(6 pt 2):592-596.
    • (1979) J Allergy Clin Immunol , vol.64 , Issue.6 PART 2 , pp. 592-596
    • Fish, J.E.1    Kelly, J.F.2
  • 37
    • 0023607936 scopus 로고
    • Allergen bronchial challenge tests: Variability and reproducibility of the early response
    • Kopferschmitt-Kubler, M.C., Bigot, H., Pauli, G. Allergen bronchial challenge tests: variability and reproducibility of the early response. J Allergy Clin Immunol 1987, 80(5):730-740.
    • (1987) J Allergy Clin Immunol , vol.80 , Issue.5 , pp. 730-740
    • Kopferschmitt-Kubler, M.C.1    Bigot, H.2    Pauli, G.3
  • 39
    • 0035057172 scopus 로고    scopus 로고
    • Does allergen immunotherapy alter the natural course of allergic disorders?
    • Yang, X. Does allergen immunotherapy alter the natural course of allergic disorders? Drugs 2001, 61(3):365-374.
    • (2001) Drugs , vol.61 , Issue.3 , pp. 365-374
    • Yang, X.1
  • 40
    • 0002430744 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases
    • World Health Organization. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 1998, 53 (Suppl):1-42.
    • (1998) Allergy , vol.53 , Issue.SUPPL. , pp. 1-42
  • 42
    • 0017078249 scopus 로고
    • Chemical modification of crude timothy grass pollen extract. I. Antigenicity and immunogenicity changes following amino group modification
    • Moran, D.M., Wheeler, A.W. Chemical modification of crude timothy grass pollen extract. I. Antigenicity and immunogenicity changes following amino group modification. Int Arch Allergy Appl Immunol 1976, 50(6):693-708.
    • (1976) Int Arch Allergy Appl Immunol , vol.50 , Issue.6 , pp. 693-708
    • Moran, D.M.1    Wheeler, A.W.2
  • 43
    • 0030752954 scopus 로고    scopus 로고
    • New routes and formulations for allergen-specific immunotherapy
    • Wheeler, A.W., Drachenberg, K.J. New routes and formulations for allergen-specific immunotherapy. Allergy 1997, 52(6):602-612.
    • (1997) Allergy , vol.52 , Issue.6 , pp. 602-612
    • Wheeler, A.W.1    Drachenberg, K.J.2
  • 44
    • 0030051668 scopus 로고    scopus 로고
    • Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: Directed induction of T-helper type-1-like activation
    • Gieni, R.S., Yang, X., Kelso, A., Hayglass, K.T. Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation. Immunology 1996, 87(1):119-126.
    • (1996) Immunology , vol.87 , Issue.1 , pp. 119-126
    • Gieni, R.S.1    Yang, X.2    Kelso, A.3    Hayglass, K.T.4
  • 45
    • 0025947122 scopus 로고
    • Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis
    • Hayglass, K.T., Stefura, W.P. Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis. J Immunol 1991, 147(8):2455-2460.
    • (1991) J Immunol , vol.147 , Issue.8 , pp. 2455-2460
    • Hayglass, K.T.1    Stefura, W.P.2
  • 46
    • 0027258831 scopus 로고
    • Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo
    • Yang, X., Gieni, R.S., Mosmann, T.R., Hay-Glass, K.T. Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo. J Exp Med 1993, 178(1):349-353.
    • (1993) J Exp Med , vol.178 , Issue.1 , pp. 349-353
    • Yang, X.1    Gieni, R.S.2    Mosmann, T.R.3    Hay-Glass, K.T.4


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