Active arsenic species produced by GSH-dependent reduction of dimethylarsinic acid cause micronuclei formation in peripheral reticulocytes of mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 539, Issue 1-2, 2003, Pages 55-63

  Kato, Koichi ^a   Yamanaka, Kenzo ^a   Hasegawa, Akira ^a   Okada, Shoji ^b  

^a NIHON UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Arsenic; Dimethylarsine; Dimethylarsinic acid; Glutathione; Micronucleus assay

Indexed keywords

ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; CACODYLIC ACID; DIMETHYLARSINOUS IODIDE; GLUTATHIONE; TRIMETHYLARSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; INJECTION; MALE; METABOLIC REGULATION; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REDUCTION; RETICULOCYTE;

EID: 0042477714     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(03)00129-3     Document Type: Article

References (31)

1. International Agency for Research on Cancer (IARC), Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Human, vol. 23, IARC, Lyon, 1980, pp. 39-141.
2. IARC, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, vols. 1-42, Suppl. 7, IARC, Lyon, 1987, pp. 100-106.
3. M.E. Vahter, Arsenic, in: T.W. Clarkson, L. Friberg, G.F. Nordberg, P.R. Sager (Eds.), Biological Monitoring of Toxic Metals, Elsevier/Plenum Press, New York, 1988, pp. 303-321.
4. Yamanaka K., Hasegawa A., Sawamura R., Okada S. Dimethylated arsenics induced DNA strand breaks in lung via the production of active oxygen in mice. Biochem. Biophys. Res. Commun. 165:1989;43-50.
5. Yamanaka K., Hoshino M., Okamoto M., Sawamura R., Hasegawa A., Okada S. Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical. Biochem. Biophys. Res. Commun. 168:1990;58-64.
6. Yamanaka K., Ohtsubo K., Hasegawa A., Hayashi H., Ohji H., Kanisawa M., Okada S. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis. 17:1996;767-770.
7. Hayashi H., Kanisawa M., Yamanaka K., Ito T., Udaka N., Ohji H., Okudera K., Okada S., Kitamura H. Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice. Cancer Lett. 125:1998;83-88.
8. Yamanaka K., Katsumata K., Ikuma K., Hasegawa A., Nakano M., Okada S. The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice. Cancer Lett. 152:2000;79-85.
9. Yamanaka K., Mizoi M., Kato K., Hasegawa A., Nakano M., Okada S. Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter. Biol. Pharm. Bull. 24:2001;510-514.
10. Yamanaka K., Hayashi H., Tachikawa M., Kato K., Hasegawa A., Oku N., Okada S. Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics. Mutat. Res. 394:1997;95-101.
11. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., Kligerman A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14:2001;355-361.
12. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74:2000;289-299.
13. Vega L., Styblo M., Patterson R., Cullen W., Wang C., Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 172:2001;225-232.
14. Thompson D.J. A chemical hypothesis for arsenic methylation in mammals. Chem. Biol. Interact. 88:1993;89-114.
15. Scott N., Hatlelid K.M., MacKenzie N.E., Carter D.E. Reactions of arsenic(III) and arsenic(V) species with glutathione. Chem. Res. Toxicol. 6:1993;102-106.
16. Delnomdedieu M., Basti M.M., Otvos J.D., Thomas D.J. Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study. Chem. Biol. Interact. 90:1994;139-155.
17. J.T. Macgregor, R. Schlegel, W.N. Choy, C.M. Wehr, Micronuclei in circulating erythrocytes: a rapid screen for chromosomal damage during routine toxicity testing in mice, in: A.W. Hayes, R.C. Schnell, T.S. Miya (Eds.), Developments in the Science and Practice of Toxicology, Elsevier, Amsterdam, 1983, pp. 555-558.
18. Noda Y., Suzuki T., Kohara A., Hasegawa A., Yotsuyanagi T., Hayashi M., Sofuni T., Yamanaka K., Okada S. In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse. Mutat. Res. 513:2002;205-212.
19. Tinwell H., Stephens S.C., Ashby J. Arsenite as the probable active species in the human carcinogenicity of arsenic: mouse micronucleus assays on Na and K arsenite, orpiment, and Fowler's solution. Environ. Health Perspect. 95:1991;205-210.
20. Deknudt G., Leonard A., Arany J., Buisson G.J., Delavignette E. In vivo studies in male mice on the mutagenic effects of inorganic arsenic. Mutagenesis. 1:1986;33-34.
21. Wang T.S., Huang H. Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells. Mutagenesis. 9:1994;253-257.
22. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 245:1990;245-249.
23. Yamauchi H., Kaise T., Takahashi K., Yamamura Y. Toxicity and metabolism of trimethylarsine in mice and hamsters. Fundam. Appl. Toxicol. 14:1990;399-407.
24. Ahmad S., Kitchin K.T., Cullen W.R. Arsenic species that cause release of iron from ferritin and generation of activated oxygen. Arch. Biochem. Biophys. 382:2000;195-202.
25. Kato K., Yamanaka K., Hasegawa A., Okada S. Dimethylarsinic acid exposure causes accumulation of Hsp72 in cell nuclei and suppresses apoptosis in human alveolar cultured (L-132) cells. Biol. Pharm. Bull. 22:1999;1185-1188.
26. Ochi T., Nakajima F., Sakurai T., Kaise T., Oya-Ohta Y. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione. Arch. Toxicol. 70:1996;815-821.
27. Ochi T., Kaise T., Oya-Ohta Y. Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells. Experientia. 50:1994;115-120.
28. Oya-Ohta Y., Kaise T., Ochi T. Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction. Mutat. Res. 357:1996;123-129.
29. Morse B.S., Conlan M., Giuliani D.G., Nussbaum M. Mechanism of arsenic-induced inhibition of erythropoiesis in mice. Am. J. Hematol. 8:1980;273-280.
30. Huang S.C., Lee T.C. Arsenite inhibits mitotic division and perturbs spindle dynamics in HeLa S3 cells. Carcinogenesis. 19:1998;889-896.
31. Kala S.V., Neely N.W., Kala G., Prater C.I., Atwood D.W., Rice J.S., Lieberman M.W. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J. Biol. Chem. 275:2000;33404-33408.