Low matrix metalloproteinase levels precede vascular lesion formation in the JCR:LA-cp rat

Molecular and Cellular Biochemistry

Volumn 249, Issue 1-2, 2003, Pages 151-155

  Wilson, David ^a,b   Massaeli, Hamid ^a,b   Russell, James C ^c   Pierce, Grant N ^a,b   Zahradka, Peter ^a,b  

^a ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Corpulent gene; JCR:LA cp rat; Matrix metalloproteinase; Smooth muscle

Indexed keywords

INSULIN; MATRIX METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME BLOOD LEVEL; ENZYME DEGRADATION; EXTRACELLULAR MATRIX; FEMALE; HYPERINSULINEMIA; INSULIN RESISTANCE; LIPID STORAGE; MALE; NONHUMAN; RAT; VASCULAR LESION;

ANIMALS; ARTERIOSCLEROSIS; DIET, ATHEROGENIC; FEMALE; INSULIN; INSULIN RESISTANCE; MALE; MATRIX METALLOPROTEINASES; MODELS, ANIMAL; OBESITY; RATS;

ANIMALIA;

EID: 0042475511     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024747008288     Document Type: Article

References (17)

1. Schwartz SM, deBlois D, O'Brien ER: The intima. Soil for atherosclerosis and restenosis. Circ Res 77: 445-465, 1995
2. Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94: 2493-2503, 1994
3. Pauly RR, Passaniti A, Bilato C, Monticone R, Cheng L, Papadopoulos N, Gluzband YA, Smith L, Weinstein C, Lakatta EG: Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation. Circ Res 75: 41-54, 1994
4. Southgate KM, Fisher M, Banning AP, Thurston VJ, Baker AH, Fabunmi RP, Groves PH, Davies M, Newby AC: Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries. Circ Res 79: 1177-1187, 1996
5. Tyagi SC, Meyer L, Schmaltz RA, Reddy HK, Voelker DJ: Proteinases and restenosis in the human coronary artery: Extracellular matrix production exceeds the expression of proteolytic activity. Atherosclerosis 116: 43-57, 1995
6. Lee RT, Schoen FJ, Loree HM, Lark MW, Libby P: Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture. Arterioscler Thromb Vasc Biol 16: 1070-1073, 1996
7. Newby AC, Zaltsman AB: Fibrous cap formation or destruction - the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation. Cardiovasc Res 41: 345-360, 1999
8. Zaltsman AB, Newby AC: Increased secretion of gelatinases A and B from the aortas of cholesterol fed rabbits: Relationship to lesion severity. Atherosclerosis 130: 61-70, 1997
9. Todor DR, Lewis I, Bruno G, Chyatte D: Identification of a serum gelatinase associated with the occurrence of cerebral aneurysms as promatrix metalloproteinase-2. Stroke 29: 1580-1583, 1998
10. Russell JC, Graham SE, Richardson M: Cardiovascular disease in the JCR:LA-cp rat. Mol Cell Biochem 188: 113-126, 1998
11. Saward L, Zahradka P: Coronary artery smooth muscle in culture: Migration of heterogeneous cell populations from vessel wall. Mol Cell Biochem 176: 53-59, 1997
12. Tyagi SC, Matsubara L, Weber KT: Direct extraction and estimation of collagenase(s) activity by zymography in microquantities of rat myocardium and uterus. Clin Biochem 26: 191-198, 1993
13. Fabunmi RP, Baker AH, Murray EJ, Booth RF, Newby AC: Divergent regulation by growth factors and cytokines of 95 and 72 kDa gelatinases and tissue inhibitors or metalloproteinases-1, -2, and -3 in rabbit aortic smooth muscle cells. Biochem J 315: 335-342, 1996
14. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Libby P: Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions. Ann NY Acad Sci 748: 501-507, 1995
15. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E, Libby P: Cytokine- stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 75: 181-189, 1994
16. Richardson M, Schmidt AM, Graham SE, Achen B, DeReske M, Russell JC: Vasculopathy and insulin resistance in the JCR:LA-cp rat. Atherosclerosis 138: 135-146, 1998
17. Bond M, Fabunmi RP, Baker AH, Newby AC: Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett 435: 29-34, 1998