Specificity of cerebellar vermian abnormalities in autism: A quantitative magnetic resonance imaging study

Journal of Child Neurology

Volumn 18, Issue 7, 2003, Pages 463-470

  Kaufmann, Walter E ^a,b   Cooper, Karen L ^a   Mostofsky, Stewart H ^a,b   Capone, George T ^a,b   Kates, Wendy R ^a,b   Newschaffer, Craig J ^c   Bukelis, Irena ^a   Stump, Mariah H ^a   Jann, Adelene E ^a   Lanham, Diane C ^a  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; AUTISM; BRAIN REGION; BRAIN SIZE; CEREBELLUM DISEASE; CEREBELLUM HYPOPLASIA; CEREBELLUM VERMIS; CHILD; CONTROLLED STUDY; COVARIANCE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DOWN SYNDROME; FACTORIAL ANALYSIS; FRAGILE X SYNDROME; HIPPOCAMPUS; HUMAN; INTELLIGENCE QUOTIENT; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

EID: 0042423534     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/08830738030180070501     Document Type: Article

References (57)

1. Bauman ML, Kemper TL: Neuroanatomic observations of the brain in autism. In: Bauman ML, Kemper TL (eds): The Neurobiology of Autism. Baltimore, Johns Hopkins University Press, 1994, 119-145.
2. Kemper TL, Bauman M: Neuropathology of infantile autism. J Neuropathol Exp Neurol 1998;57:645-652.
3. Ritvo ER, Freeman BJ, Scheibel AB, et al: Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC Autopsy Research Report. Am J Psychiatry 1986;143:862-866.
4. Saitoh O, Courchesne E: Magnetic resonance imaging study of the brain in autism. Psychiatry Clin Neurosci 1998;52(Suppl): S219-S222.
5. Courchesne E, Yeung-Courchesne R, Press GA, et al: Hypoplasia of cerebellar vermal lobules VI and VII in autism. N Engl J Med 1988;318:1349-1354.
6. Murakami JW, Courchesne E, Press GA, et al: Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia in autism. Arch Neurol 1989;46:689-694.
7. Courchesne E, Saitoh O, Yeung-Courchesne R, et al: Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: Identification of hypoplastic and hyperplastic subgroups with MR imaging. AJR Am J Roentgenol 1994;162: 123-130.
8. Kates WR, Mostofsky SH, Zimmerman AW, et al: Neuroanatomic and neurocognitive differences in a pair of monozygous twins discordant for strictly defined autism. Ann Neurol 1998;43:782-791.
9. Courchesne E, Karns CM, Davis HR, et al: Unusual brain growth patterns in early life in patients with autistic disorder. An MRI study. Neurology 2001;57:245-254.
10. Hashimoto T, Tayama M, Miyazaki M, et al: Brainstem and cerebellar vermis involvement in autistic children. J Child Neurol 1993; 8:149-153.
11. Levitt JG, Blanton R, Capetillo-Cunliffe L, et al: Cerebellar vermis lobules VIII-X in autism. Prog Neuropsychopharmacol Biol Psychiatry 1999;23:625-633.
12. Schaefer GB, Thompson JN, Bodensteiner JB, et al: Hypoplasia of the cerebellar vermis in neurogenetic syndromes. Ann Neurol 1996;39:382-385.
13. Piven J, Saliba K, Bailey J, et al: An MRI study of autism: The cerebellum revisited. Neurology 1997;49:546-551.
14. Harris NS, Courchesne E, Townsend J, et al: Neuroanatomic contributions to slowed orienting of attention in children with autism. Cogn Brain Res 1999;8:61-71.
15. Townsend J, Courchesne E, Covington J, et al: Spatial attention deficits in patients with acquired or developmental cerebellar abnormality. J Neurosci 1999;19:5632-5643.
16. Pierce K, Courchesne E: Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol Psychiatry 2001;49:655-664.
17. Kaufmann WE, Moser HW: Dendritic anomalies in disorders associated with mental retardation. Cereb Cortex 2000;10:981-991.
18. Coe DA, Matson JL, Russell DW, et al: Behavior problems of children with Down syndrome and life events. J Autism Dev Disord 1999;29:149-156.
19. Gath A, Gumley D: Behaviour problems in retarded children with special reference to Down's syndrome. Br J Psychiatry 1986; 149:156-161.
20. Gillberg C, Persson E, Grufman M, et al: Psychiatric disorders in mildly and severely mentally retarded urban children and adolescents: Epidemiological aspects. Br J Psychiatry 1986;149:68-74.
21. Myers BA, Pueschel SM: Psychiatric disorders in persons with Down syndrome. J Nerv Ment Dis 1991;179:609-613.
22. Kent L, Evans J, Paul M, et al: Comorbidity of autistic spectrum disorders in children with Down syndrome. Dev Med Child Neurol 1999;41:153-158.
23. Kemper TL: Neuropathology of Down syndrome. In: Nadel L (ed): The Psychobiology of Down Syndrome. Cambridge, MA, MIT Press, 269-289.
24. Baxter LL, Moran TH, Richtsmeier JT, et al: Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet 2000;9:195-202.
25. Raz N, Torres IJ, Briggs SD, et al: Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: Evidence from MRI morphometry. Neurology 1995;45:356-366.
26. Aylward EH, Habbak R, Warren AC, et al: Cerebellar volume in adults with Down syndrome. Arch Neurol 1997;54:209-212.
27. Pinter JD, Eliez S, Schmitt JE, et al: Neuroanatomy of Down's syndrome: A high-resolution MRI study. Am J Psychiatry 2001;158: 1659-1665.
28. Kaufmann WE, Reiss AL: Molecular and cellular genetics of fragile X syndrome. Am J Med Genet 1999;88:11-24.
29. Bailey DB Jr, Mesibov GB, Hatton DD, et al: Autistic behavior in young boys with fragile X syndrome. J Autism Dev Disord 1998;28: 499-508.
30. Rogers SJ, Wehner DE, Hagerman R: The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. J Dev Behav Pediatr 2001;22:409-417.
31. Kau ASM, Meyer WA, Kaufmann WE: Early development in males with fragile X syndrome: A review of the literature. Microsc Res Tech 2002;57:174-178.
32. Kates WR, Folley BS, Lanham DC, et al: Cerebral growth in fragile X syndrome: Review and comparison with Down syndrome. Microsc Res Tech 2002;57:159-167.
33. Reiss AL, Patel S, Kumar AJ, et al: Preliminary communication: Neuroanatomical variations of the posterior fossa in men with the fragile X (Martin-Bell) syndrome. Am J Med Genet 1988;31:407-414.
34. Reiss AL, Aylward E, Freund LS, et al: Neuroanatomy of fragile X syndrome: The posterior fossa. Ann Neurol 1991;29:26-32.
35. Mostofsky SH, Mazzocco MM, Aakalu G, et al: Decreased cerebellar posterior vermis size in fragile X syndrome: Correlation with neurocognitive performance. Neurology 1998;50:121-130.
36. Mazzocco MM, Kates WR, Baumgardner TL, et al: Autistic behaviors among girls with fragile X syndrome. J Autism Dev Disord 1997;27:415-435.
37. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, 4th ed. Washington, DC, American Psychiatric Press, 1994.
38. Lord C, Rutter M, Le Couteur A: Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994;24:659-685.
39. Lord C, Rutter M, DiLavore PC: Autism Diagnostic Observation Schedule-Generic. Chicago, University of Chicago, 1998.
40. Thorndike R, Hagen E, Sattler J: Guide for Administering and Scoring the Fourth Edition Stanford-Binet Intelligence Scale. Chicago, The Riverside Publishing Company, 1986.
41. Nordin V, Gillberg C: Autism spectrum disorders in children with physical or mental disability or both. II: Screening aspects. Dev Med Child Neurol 1996;38:314-324.
42. Bayley N: Bayley Scales of Infant Development: Second Edition Manual. San Antonio, TX, Psychological Corporation, 1993.
43. Achenbach TM: Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington, VT, University of Vermont, 1991.
44. Quay HC, Peterson DR: Manual for the Revised Behaviour Problem Checklist. Coral Gables, FL, University of Miami, Department of Psychology, 1987.
45. Wechsler D: Wechsler Intelligence Scale for Children-Revised. New York, Psychological Corporation, 1991.
46. Mostofsky SH, Reiss AL, Lockhart P, et al: Evaluation of cerebellar size in attention-deficit hyperactivity disorder. J Child Neurol 1998;13:434-439.
47. Reiss AL: BrainImage. Palo Alto, CA, Department of Psychiatry, Stanford University, 1998.
48. Daniels DL, Haughton VM, Naidich TP: Cranial and Spinal Magnetic Resonance Imaging. An Atlas and Guide. New York, Raven Press, 1987.
49. Fredericksen KA, Cutting LE, Kates WR, et al: Disproportionate increases of white matter in right frontal lobe in Tourette syndrome. Neurology 2002;58:85-89.
50. Pennington BF, Filipek PA, Lefly D, et al: A twin MRI study of size variations in human brain. J Cogn Neurosci 2000;12:223-232.
51. Sparks BF, Friedman SD, Shaw DW, et al: Brain structural abnormalities in young children with autism spectrum disorder. Neurology 2002;59:184-192.
52. Castellanos FX, Giedd JN, Berquin PC, et al: Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2001;58:289-295.
53. Casanova MF, Buxhoeveden DP, Switala AE, Roy E: Asperger's syndrome and cortical neuropathology. J Child Neurol 2002;17: 142-145.
54. Carper RA, Courchesne E: Inverse correlation between frontal lobe and cerebellum sizes in children with autism. Brain 2000; 123:836-844.
55. Kates WR, Abrams MT, Kaufmann WE, et al: Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res 1997;75:31-48.
56. Eliez S, Blasey CM, Freund LS, et al: Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome. Brain 2001;124:1610-1618.
57. Kaufmann WE: Neurobiology of fragile X syndrome: From molecular genetics to neurobehavioral phenotype. Microsc Res Tech 2002;57:131-134.