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Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria
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O'Donnell R.A., Koning-Ward T.F., Burt R.A., Bockarie M., Reeder J.C., Cowman A.F., Crabb B.S. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med. 193:2001;1403-1412.
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Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: A randomized trial
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Birkett A., Lyons K., Schmidt A., Boyd D., Oliveira G.A., Siddique A., Nussenzweig R., Calvo-Calle J.M., Nardin E. A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in pre-clinical analyses in rodent and primate hosts. Infect Immun. 70:2002;6860-6870.
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Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease
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Campos-Neto A., Porrozzi R., Greeson K., Coler R.N., Webb J.R., Seiky Y.A., Reed S.G., Grimaldi G. Jr. Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease. Infect Immun. 69:2001;4103-4108.
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Campos-Neto A., Webb J.R., Greeson K., Coler R.N., Skeiky Y.A., Reed S.G. Vaccination with plasmid DNA encoding TSA/LmSTI1 leishmanial fusion proteins confers protection against Leishmania major infection in susceptible BALB/c mice. Infect Immun. 70:2002;2828-2836.
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Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant
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Skeiky Y.A., Coler R.N., Brannon M., Stromberg E., Greeson K., Crane R.T., Campos-Neto A., Reed S.G. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. Vaccine. 20:2002;3292-3303.
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0036073291
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Immunization with a polyprotein vaccine consisting of the T-Cell antigens thiol-specific antioxidant, Leishmania major stress-inducible protein 1, and Leishmania elongation initiation factor protects against leishmaniasis
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Using MPL®, a potent adjuvant acceptable for human use, a polyprotein consisting of three important leishmania antigens protected highly susceptible Balb/c mice with as little as 2μg protein.
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Coler R.N., Skeiky Y.A., Bernards K., Greeson K., Carter D., Cornellison C.D., Modabber F., Campos-Neto A., Reed S.G. Immunization with a polyprotein vaccine consisting of the T-Cell antigens thiol-specific antioxidant, Leishmania major stress-inducible protein 1, and Leishmania elongation initiation factor protects against leishmaniasis. Infect Immun. 70:2002;4215-4225 Using MPL®, a potent adjuvant acceptable for human use, a polyprotein consisting of three important leishmania antigens protected highly susceptible Balb/c mice with as little as 2μg protein.
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Successful use of a defined antigen/GM-CSF adjuvant vaccine to treat mucosal leishmaniasis refractory to antimony: A case report
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Badaro R., Lobo I., Nakatani M., Muinos A., Netto E.M., Coler R.N., Reed S.G. Successful use of a defined antigen/GM-CSF adjuvant vaccine to treat mucosal leishmaniasis refractory to antimony: a case report. Braz J Infect Dis. 5:2001;223-232.
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Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein
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Borges M.M., Campos-Neto A., Sleath P., Grabstein K.H., Morrissey P.J., Skeiky Y.A., Reed S.G. Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein. Infect Immun. 69:2001;5270-5277.
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Toward a defined anti-Leishmania vaccine targeting vector antigens: Characterization of a protective salivary protein
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Valenzuela J.G., Belkaid Y., Garfield M.K., Mendez S., Kamhawi S., Rowton E.D., Sacks D.L., Ribeiro J.M. Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. J Exp Med. 194:2001;331-342.
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A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
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Sambandamurthy V.K., Wang X., Chen B., Russell R.G., Derrick S., Collins F.M., Morris S.L., Jacobs W.R. Jr. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med. 8:2002;1171-1174.
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Hondalus M.K., Bardarov S., Russell R., Chan J., Jacobs W.R. Jr., Bloom B.R. Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infect Immun. 68:2000;2888-2898.
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0032982779
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Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine
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Jackson M., Phalen S.W., Lagranderie M., Ensergueix D., Chavarot P., Marchal G., McMurray D.N., Gicquel B., Guilhot C. Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine. Infect Immun. 67:1999;2867-2873.
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Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates
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Smith D.A., Parish T., Stoker N.G., Bancroft G.J. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun. 69:2001;1142-1150.
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Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes
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Gierynska M., Kumaraguru U., Eo S.K., Lee S., Krieg A., Rouse B.T. Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes. J Virol. 76:2002;6568-6576.
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Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6
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Weinrich O.A., van Pinxteren L.A., Meng O.L., Birk R.P., Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun. 69:2001;2773-2778.
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Prospects for a better vaccine against tuberculosis
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in press. [Au: do you have any further details of this paper yet?]
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Reed SG, Alderson MR, Dalemans W, Lobet Y, Skeiky YAW: Prospects for a better vaccine against tuberculosis. Tuberculosis 2003, in press. [Au: do you have any further details of this paper yet?].
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Reed, S.G.1
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24
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0037013966
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NadA, a novel vaccine candidate of Neisseria meningitidis
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This paper describes an interesting cell-surface protein in N. meningitidis, which is present in 52 out of 53 virulent strains of the bacteria. This molecule induces strong bactericidal and protective antibodies in infant rat model of the infection, thus suggesting that this protein may be a novel vaccine candidate to control meningococcal diseases.
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Comanducci M., Bambini S., Brunelli B., Adu-Bobie J., Arico B., Capecchi B., Giuliani M.M., Masignani V., Santini L., Savino S.et al. NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med. 195:2002;1445-1454 This paper describes an interesting cell-surface protein in N. meningitidis, which is present in 52 out of 53 virulent strains of the bacteria. This molecule induces strong bactericidal and protective antibodies in infant rat model of the infection, thus suggesting that this protein may be a novel vaccine candidate to control meningococcal diseases.
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Comanducci, M.1
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25
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0037076401
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Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus
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This paper describes a rapid and efficient antigen discovery strategy for the identification and cloning of genes encoding microbial cell surface proteins. Such an approach is a major advance in the development of vaccines against extracellular microorganisms.
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Etz H., Minh D.B., Henics T., Dryla A., Winkler B., Triska C., Boyd A.P., Sollner J., Schmidt W., von Ahsen U.et al. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Proc Natl Acad Sci USA. 99:2002;6573-6578 This paper describes a rapid and efficient antigen discovery strategy for the identification and cloning of genes encoding microbial cell surface proteins. Such an approach is a major advance in the development of vaccines against extracellular microorganisms.
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Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
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Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
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Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T.et al. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature. 404:2000;502-506.
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Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
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Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
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Pym A.S., Brodin P., Majlessi L., Brosch R., Demangel C., Williams A., Griffiths K.E., Marchal G., Leclerc C., Cole S.T. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med. 9:2003;533-539.
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Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis Bacillus Calmette-Guerin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis
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Bao L., Chen W., Zhang H., Wang X. Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis Bacillus Calmette-Guerin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Infect Immun. 71:2003;1656-1661.
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A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis
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Horwitz M.A., Harth G. A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis. Infect Immun. 71:2003;1672-1679.
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