Endothelial dysfunction and pre-symptomatic atherosclerosis in type 1 diabetes - Pathogenesis and identification

British Journal of Diabetes and Vascular Disease

Volumn 3, Issue 1, 2003, Pages 27-34

  Browne, Duncan ^a   Meeking, Darryl ^b   Shaw, Kenneth ^b   Cummings, Michael ^b  

^a QUEEN ALEXANDRA HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Atherosclerosis; Forearm; Nitric oxide; Type 1 diabetes; Vascular endothelium

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALBUMIN; ARGININE; BIOCHEMICAL MARKER; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN; FREE RADICAL; HOMOCYSTEINE; INSULIN; LIPID; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYOL; PROSTANOID; PROTEIN KINASE C; THROMBOMODULIN; TISSUE FACTOR PATHWAY INHIBITOR; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ATHEROSCLEROSIS; BIOAVAILABILITY; BIOPHYSICS; BLOOD FLOWMETRY; BLOOD GLUCOSE MONITORING; DIAGNOSTIC PROCEDURE; ENDOTHELIUM LESION; FOREARM BLOOD FLOW; HEMODYNAMICS; HUMAN; HYPERGLYCEMIA; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; MEDICAL RESEARCH; METHODOLOGY; MICROALBUMINURIA; PATHOGENESIS; REVIEW; SYMPTOMATOLOGY; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0042388044     PISSN: 14746514     EISSN: None     Source Type: Journal    
DOI: 10.1177/14746514030030010401     Document Type: Review

References (71)

1. Krolewski AS, Kosinski EJ, Warram JH et al. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol 1987;59:750-5.
2. Kannel WB, Kannel C, Paffenberger RS Jr et al. Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J 1987;13:1489-99.
3. Moorish NJ, Stevens LK, Fuller JH et al. Risk factors for macrovascular disease in diabetes mellitus: the London follow-up to the WHO Multinational Study of Vascular Disease in Diabetics. Diabetologia 1991;34:590-4.
4. Peppa-Patrikou M, Scordili M, Antoniou A et al. Carotid atherosclerosis in adolescents with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. Diabetes Care 1998;21:1004-07.
5. Hadock S, Richardson M, Winocour PH et al. Intimal alterations in rabbit aortas during the first 6 months of alloxan-induced diabetes. Arterioscler Thromb Vasc Biol 1991;11:517-29.
6. Ross R. The pathogenesis of atherosclerosis; a perspective for the 1990's. Nature 1993;362:801-09.
7. Calermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial function in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-15.
8. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002;90(10C):L40-8.
9. Storey AM, Perry CJ, Petrie JR. Endothelial dysfunction in type 2 diabetes. Br J Diabetes Vasc Dis 2001;1:22-7.
10. Moncada S, Radomski MW, Palmer RMJ. Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol 1988;37:2495-501.
11. Crea F, Biasucci HM, Buffon A et al. Role of inflammation in the pathogenesis of unstable coronary artery disease. Am J Cardiol 1997;80:10-16E.
12. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 2001;88:756-62.
13. Diodati JG, Dakak N, Gilligan DM et al. Effect of atherosclerosis on endothelium-dependent inhibition of platelet activation in humans. Circulation 1998;98:17-24.
14. Stehouwer CD, Lambert J, Donker AJ et al. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 1997;34:55-68.
15. Pieper GM. Enhanced, unaltered and impaired nitric oxide mediated endothelium dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 1999;42:204-13.
16. Benjamin N, Calver A, Collier J et al. Measuring forearm bloodflow and interpreting the responses to drugs and mediators. Hypertension 1995; 25:918-23.
17. Ludmer PL, Selwyn AP, Shook TI et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-51.
18. Takase B, Akima T, Uehata A et al. Close relation between endothelium-dependent flow mediated vasodilation in coronary and brachial artery in human. J Am Coll Cardiol 1998;31:359A.
19. Clarkson P, Celermajer DS, Donald AE et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol 1996;28:573-9.
20. Schroeder S, Enderle MD, Ossen R et al. Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: Pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging. Am Heart J 1999;138:731-9.
21. Drexler H, Zeiher AM. Progression of coronary endothelial dysfunction in men and its potential clinical significance. Basic Res Cardiol 1991;86: 223-32.
22. Chowienczyk PJ, Cockcroft JR, Ritter JM. Differential inhibition by NG-monomethyl-L-arginine of vasodilator effects of acetylcholine and methacholine in human forearm vasculature. Br J Pharmacol 1993;110: 736-8.
23. Chowienczyk PJ, Cockcroft JR, Ritter JM. Blood flow responses to intra-arterial acetylcholine in man: effects of basal flow and conduit vessel length. Clin Sci 1994;87:45-51.
24. Rossi M, Lall K, Standfield N, Dornhurst A. Impaired vasoconstriction of peripheral cutaneous blood flow in type 1 diabetic patients following food ingestion. Diabetic Med 1998;15:463-6.
25. Pitkanen OP, Nuutila P, Raitakari OT et al. Coronary Flow reserve is reduced in young men with IDDM. Diabetes 1998;47:248-54.
26. Lehmann ED, Hopkins KD, Rawesh A et al. Relation between number of cardiovascular risk factors/events and noninvasive Doppler ultrasound assessments of aortic compliance. Hypertension 1998;32:565-9.
27. Nicolaides E, Jones CJH. Type 2 diabetes - implications for macrovascular mechanics and disease. Br J Diabetes Vasc Dis 2002;2:9-12.
28. Brooks B, Molyneaux L, Yue DK. Augmentation of central arterial pressure in type 1 diabetes. Diabetes Care 1999;22:1722-7.
29. Westerbacka J, Uosukainen A, Makimattila S et al. Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus. Hypertension 2000;35:1043-8.
30. van Veen S, Chang PC. Prostaglandin and nitric oxide mediate insulin-induced vasodilation in the human forearm. Cardiovasc Res 1997;34: 223-9.
31. Bots ML, Hoes AW, Hoffman A et al. Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions. J Intern Med 1999;245:269-76.
32. McVeigh GF, Hamilton PK, Morgan DR. Evaluation of mechanical arterial properties: clinical, experimental and therapeutic aspects. Clin Sci 2002;102:51-67.
33. Zureik M, Ducimetiere P, Touboul PJ et al. Common carotid intima-media thickness predicts occurrence of carotid atherosclerotic plaques: longitudinal results from the Aging Vascular Study (EVA) study. Arterioscler Thromb Vasc Biol 2000;20:1622-9.
34. Balbarini A, Buttitta F, Limbruno U et al. Usefulness of carotid intimamedia thickness measurement and peripheral B-mode ultrasound scan in the clinical screening of patients with coronary artery disease. Angiology 2000;51:269-70.
35. Effect of intensive diabetes treatment on carotid artery wall thickness in the epidemiology of diabetes interventions and complications. Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Diabetes 1999;48:383-90.
36. Huvers FC, De Leeuw PW, Alfons JHM et al. Endothelium-dependent vasodilation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycaemic conditions. Diabetes 1999;47:1300-07.
37. Elhadd TA, Kennedy G, Hill A et al. Abnormal markers of endothelial cell activation and oxidative stress in children, adolescents and young adults with type 1 diabetes with no clinical evidence of vascular disease. Diabetes Metab Res Rev 1999;15:405-11.
38. Hofmann MA, Kohl B, Zumbach MS et al. Hyperhomocysteinaemia and endothelial dysfunction in IDDM. Diabetes Care 1998;21:841-8.
39. Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T. Endothelial dysfunction by acute hyperhomocysteinaemia: restoration by folic acid. Clin Sci 1999;96:235-9.
40. Poston L, Taylor PD. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci 1995;88:245-55.
41. Chan NN, Vallance P, Colhoun HM. Nitric oxide and vascular responses in type 1 diabetes. Diabetologia 2000;43:137-47.
42. Johnstone MT, Creager SJ, Scales KM et al. Impaired endothelium-dependent vasodilatation in patients with insulin-dependent diabetes mellitus. Circulation 1993;88:2510-16.
43. Williams SB, Goldfine AB, Timimi FK et al. Acute hyperglycaemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998;97:1695-701.
44. Akbari CM, Saouaf R, Barnhill DF et al. Endothelium-dependent vasodilation is impaired in both microcirculation and macrocirculation during acute hyperglycaemia. J Vasc Surg 1998;28:687-94.
45. Macklin AV, Viberti GC, Ritter J. Forearm blood flow in type 1 diabetics during systemic hyperglycemia. Diabetologia 1998;41:A310.
46. Avogadro A, Calo L, Piarulli F et al. Effect of acute ketosis on the endethelial function of type 1 diabetic patients: The role of nitric oxide. Diabetes 1999;48:391-7.
47. Wang W, Diamond SL. Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells. Biochem Biophys Res Commun 1997;233:748-51.
48. Cardillo C, Nambi SS, Kilcoyne CM et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation 1999; 100:820-5.
49. Dogra G, Rich L, Stanton K et al. Endothelium-dependent and independent vasodilation studies at normoglycaemia in type 1 diabetes with and without microalbuminuria. Diabetologia 2001;44:593-601.
50. Stuhlinger MC, Tsao PS, Her JH et al. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001;104:2569-75.
51. O'Byrne SO, Forte P, Roberts J et al. Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. Diabetes 2000;49:857-62.
52. Meeking DR, Browne DL, Allard S et al. Effects of cyclo-oxygenase inhibition on vasodilatory response to acetylcholine in patients with type 1 diabetes and nondiabetic subjects. Diabetes Care 2000;23:1840-3.
53. Browne DL, Allard SE, Munday LJ et al. The relative contributions and synergy between vasodilatory prostanoids and nitric oxide in determining endothelial function in type 1 diabetes. Diabetes 2001;50(suppl 2):A599.
54. 2. Am J Physiol 1989;257:H1327-33.
55. Tesfamariam B, Brown ML, Deykin D, Cohen RA. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest 1990;85:929-32.
56. Katusic ZS, Schugel J, Consentino F et al. Endothelium dependent contractions to oxygen-derived free radicals in the canine basilar artery. Am J Physiol 1993;264:H859-64.
57. Thorne S, Mullen MJ, Clarkson P et al. Early endothelial dysfunction in adults at risk from atherosclerosis: different responses to L-arginine. J Am Coll Cardiol 1998;32:110-16.
58. Schade DS, Eaton RP, Freidman N et al. The intravenous, intraperitoneal and subcutaneous routes of insulin delivery in diabetic man. Diabetes 1979;28:1069-72.
59. Wolf BA, Williamson JR, Eason RA et al. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. J Clin Invest 1991;87:31-8.
60. Hawthorne GC, Bartlett K, Hetherington CS et al. The effect of high glucose on polyol pathway activity and myoinositol metabolism in cultured human endothelial cells. Diabetologia 1989;32:196-9.
61. Tesfamariam B, Palacino JJ, Weisbrod RM et al. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol 1993;21:205-11.
62. Bucula R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes. J Clin Invest 1991;87:432-8.
63. Watts GF, Playford DA. Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis. Atherosclerosis 1998;141:17-30.
64. Kugiyama K, Kerns SA, Morriset JD et al. Impairment of endothelium-dependent relaxation by lysolecithin in modified low density lipoprotein Nature 1990;344:160-2.
65. Laakso M, Edelmann SV, Bretchel G et al. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992;41: 1076-83.
66. Skyrme-Jones RAP, Berry KL, O'Brien RC et al. Basal and exercise-induced skeletal muscle blood flow is augmented in type 1 diabetes mellitus. Clin Sci 2000;98:111-20.
67. Tooke JE. Microvascular haemodynamics in diabetes mellitus. Clin Sci 1986;70:119-25.
68. Parving HH, Viberti GC, Keen H et al. Haemodynamic factors in the genesis of diabetic microangiopathy. Metabolism 1983;32:943-9.
69. Christensen NJ. A reversible vascular abnormality associated with diabetic ketosis. Clin Sci 1970;39:539-48.
70. Taddei S, Galetta F, Virdis A et al. Physical activity prevents age related impairment in nitric oxide availability in elderly athletes. Circulation 2000; 101:2896-901.
71. Pieper GM. Enhanced, unaltered and impaired nitric oxide mediated endothelium dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 1999;42:204-13.