Mathematical modeling of drug release from bioerodible microparticles: Effect of gamma-irradiation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 56, Issue 2, 2003, Pages 271-279

  Faisant, N ^a   Siepmann, J ^b   Richard, J ^c   Benoit, J P ^a  

^a UNIVERSITÉ D'ANGERS   (France)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Ethypharm   (France)

Author keywords

Bioerosion; Microparticle; Modeling; PLGA; Irradiation

Indexed keywords

FLUOROURACIL; OIL; POLYGLACTIN; WATER;

ARTICLE; CHEMICAL PHENOMENA; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DIFFUSION; DRUG RELEASE; GAMMA IRRADIATION; GEL PERMEATION CHROMATOGRAPHY; GEOMETRY; MATHEMATICAL MODEL; MONTE CARLO METHOD; PARTICLE SIZE; PHYSICAL CHEMISTRY; PHYSICAL PHENOMENA; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION RESPONSE; SCANNING ELECTRON MICROSCOPY; SOLVENT EXTRACTION; STEADY STATE;

EID: 0042335984     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00104-8     Document Type: Article

References (22)

1. Volland C., Wolff M., Kissel T. The influence of terminal gamma-sterilization on captopril containing poly(D,L-lactide-co-glycolide) microspheres. J. Controlled Release. 31:1994;293-305.
2. Mohr D., Wolff M., Kissel T. Gamma irradiation for terminal sterilization of 17β-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticles. J. Controlled Release. 61:1999;203-217.
3. Hausberger A.G., Kenley R.A., DeLuca P.P. Gamma irradiation effects on molecular weight and in vitro degradation of poly(D,L-lactide-co-glycolide) microparticles. Pharm. Res. 12:1995;851-856.
4. Bittner B., Mäder K., Kroll C., Borchert H.-H., Kissel T. Tetracycline-HCl-loaded poly(D,L-lactide-co-glycolide) microspheres prepared by a spray drying technique: influence of γ-irradiation on radical formation and polymer degradation. J. Controlled Release. 59:1999;23-32.
5. Montanari L., Cilurzo F., Valvo L., Faucitano A., Buttafava A., Groppo A., Genta I., Conti B. Gamma irradiation effects on stability of poly(lactide-co-glycolide) microspheres containing clonazepam. J. Controlled Release. 75:2001;317-330.
6. Faisant N., Siepmann J., Oury P., Laffineur V., Bruna E., Haffner J., Benoit J.P. The effect of gamma-irradiation on drug release from bioerodible microparticles: A quantitative treatment. Int. J. Pharm. 242:2002;281-284.
7. Gèze A., Venier-Julienne M.C., Cottin J., Faisant N., Benoit J.P. PLGA microsphere bioburden evaluation for radiosterilization dose selection. J. Microencapsulation. 18:2001;627-636.
8. Siepmann J., Göpferich A. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv. Drug Del. Rev. 48:2001;229-247.
9. Göpferich A. Mechanisms of polymer degradation and erosion. Biomaterials. 17:1996;103-114.
10. Göpferich A. Erosion of composite polymer matrices. Biomaterials. 18:1997;397-403.
11. Zygourakis K. Discrete simulations and bioerodible controlled release systems. Polym. Prep. ACS. 30:1989;456-457.
12. Göpferich A. Bioerodible implants with programmable drug release. J. Controlled Release. 44:1997;271-281.
13. Faisant N., Siepmann J., Benoit J.P. PLGA-based microparticles: Elucidation of mechanisms and a new, simple mathematical model quantifying drug release. Eur. J. Pharm. Sci. 15:2002;355-366.
14. Siepmann J., Faisant N., Benoit J.P. A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations. Pharm. Res. 19:2002;1885-1893.
15. Boisdron-Celle M., Menei P., Benoit J.P. Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers. J. Pharm. Pharmacol. 47:1995;108-114.
16. Menei P., Boisdron-Celle M., Croue A., Guy G., Benoit J.P. Effect of stereotactic implantation of bioerodible 5-Fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats. Neurosurgery. 39:1996;117-124.
17. Menei P., Venier-Julienne M.C., Gamelin E., Saint-Andre J.-P., Hayek G., Jadaud E., Fournier D., Mercier P., Guy G., Benoit J.P. Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: A pilot study. Cancer. 86:1999;324-329.
18. Higuchi T. Rate of release of medicaments from ointment bases containing drugs in suspensions. J. Pharm. Sci. 50:1961;874-875.
19. Higuchi T. Mechanisms of sustained action mediation. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52:1963;1145-1149.
20. Koizumi T., Panomsuk S.P. Release of medicaments from spherical matrices containing drug in suspension: Theoretical aspects. Int. J. Pharm. 116:1995;45-49.
21. Crank J. The Mathematics of Diffusion. 1975;Clarendon Press, Oxford.
22. Fan L.T., Singh S.K. Controlled Release: A Quantitative Treatment. 1989;Springer-Verlag, Berlin.