A randomized, double-blind, placebo-controlled trial of concomitant pilocarpine with head and neck irradiation for prevention of radiation-induced xerostomia

Radiotherapy and Oncology

Volumn 64, Issue 1, 2002, Pages 29-32

  Haddad, Peiman ^a   Karimi, Masoumeh ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Pilocarpine; Radiation; Xerostomia

Indexed keywords

PILOCARPINE; PLACEBO;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; LACRIMATION; MALE; NAUSEA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME; XEROSTOMIA; ADOLESCENT; DRUG ADMINISTRATION; HEAD AND NECK TUMOR; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PAROTID GLAND; RADIATION EXPOSURE; RADIATION INJURY; RADIOTHERAPY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; HEAD AND NECK NEOPLASMS; HUMANS; MIDDLE AGED; PAROTID GLAND; PILOCARPINE; RADIATION INJURIES; RADIOTHERAPY; RADIOTHERAPY DOSAGE; XEROSTOMIA;

EID: 0036661290     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(02)00104-4     Document Type: Article

References (10)

1. Fox P.C. Acquired salivary dysfunction; drugs and radiation. Ann N Y Acad Sci. 842:1998;132-137.
2. Horiot J.C., Lipinski F., Schraub S., et al. Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study. Radiother Oncol. 55:(3):2000;233-239.
3. Johnson J.T., Ferretti G.A., Nethery W.J., et al. Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med. 329:(6):1993;390-395.
4. LENT SOMA scales for all anatomic sites (no author listed). Int J Radiat Oncol Biol Phys 1995;31(5):1049-1091.
5. LeVeque F.G., Montgomery M., Potter D., et al. A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol. 11:(6):1993;1124-1131.
6. Pilocarpine systemic. In: Klasco RK, Gelman CR, editors. USP DI Drug Information for the Healthcare Professional. Greenwood Village, CO: Micromedex, 2000. pp. 2483-2485.
7. Reddy S.P., Leman C.R., Marks J.E., Emami B. Parotid-sparing irradiation for cancer of the oral cavity; maintenance of oral nutrition and body weight by preserving parotid function. Am J Clin Oncol (CCT). 24:(4):2001;341-346.
8. Taylor S.E., Miller E.G. Preemptive pharmacologic intervention in radiation-induced salivary dysfunction. Proc Soc Exp Biol Med. 221:(1):1999;14-26.
9. Valdez I.H., Wolff A., Atkinson J.C., Macynski A.A., Fox P.C. Use of pilocarpine during head and neck radiation therapy to reduce xerostomia and salivary dysfunction. Cancer. 71:(5):1993;1848-1851.
10. Zimmerman R.P., Mark R.J., Tran L.M., Juillard G.F. Concomitant pilocarpine during head and neck irradiation is associated with decreased posttreatment xerostomia. Int J Radiat Oncol Biol Phys. 37:(3):1997;571-575.