Air pollution particles produce airway wall remodeling in rat tracheal explants

American Journal of Respiratory Cell and Molecular Biology

Volumn 29, Issue 3 I, 2003, Pages 352-358

  Dai, Jin ^b   Xie, Changshi ^b   Vincent, Renaud ^b   Churg, Andrew ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIOXIDANT; DEFEROXAMINE; FETUIN; HYDROXYPROLINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROCOLLAGEN; SYNAPTOPHYSIN; TETRAMETHYLTHIOUREA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

AIR POLLUTANT; AIRWAY OBSTRUCTION; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; EXHAUST GAS; EXPLANT; FIBROGENESIS; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PARTICULATE MATTER; PROTEIN EXPRESSION; RAT; TRACHEA;

AIR POLLUTION; ALPHA-FETOPROTEINS; ANIMALS; CELLS, CULTURED; CHELATING AGENTS; COLLAGEN; DEFEROXAMINE; DNA, COMPLEMENTARY; ENZYME INHIBITORS; FIBROSIS; FLAVONOIDS; GENE EXPRESSION REGULATION; HYDROXYPROLINE; IMIDAZOLES; IRON; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; OXIDANTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PROCOLLAGEN; PROMOTER REGIONS (GENETICS); PYRIDINES; RATS; THIOUREA; TIME FACTORS; TRACHEA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 0042330293     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0318OC     Document Type: Article

References (35)

1. Pope, C. A., III. 2000. Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk. Environ. Health Perspect. 108:713-723.
2. Pope, C. A., III, R. T. Burnett, M. J. Thun. E. E. Calle, D. Krewski, K. Ito, and G. D. Thurston. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 287:1132-1141.
3. Abbey, D. E., R. J. Burchette, S. F. Knutsen, W. F. McDonnell, M. D. Lebowitz, and P. L. Enright. 1998. Long-term particulate and other air pollutants and lung function in nonsmokers. Am. J. Respir. Crir. Care Med. 158:289-298.
4. Sunyer, J. 2001. Urban air pollution and chronic obstructive pulmonary disease: a review. Eur. Respir. J. 17:1024-1033.
5. Perez-Padilla, R., J. Regalado, S. Vedal, P. Pare, R. Chapela, R. Sansores, and M. Selman. 1996. Exposure to biomass smoke and chronic airway disease in Mexican women. Am. J. Respir. Crit. Care Med. 154:701-706.
6. Souzca, M. B., P. H. Saldiva, C. A. Pope, III, and V. L. Capelozzi. 1998. Respiratory changes due to long-term exposure to urban levels of air pollution: a histopathologic study in humans. Chest 113:1312-1318.
7. Pinkerton, K. E., F. H. Green, C. Saiki, V. Vallyathan, C. G. Plopper, V. Gopal, D. Hung, E. B. Bahne, S. S. Lin, M. G. Menache, and M. B. Schenker. 2000. Distribution of particulate matter and tissue remodeling in the human lung. Environ. Health Perspect. 108:1063-1069.
8. Churg, A., M. Brauer, M. Carmen Avila-Casado, T. I. Fortoul, and J. Wright. 2003. Chronic exposure to high levels of particulate air pollution and small airways remodeling. Environ. Heahh Perspect. 111:714-718.
9. Pare, P. D., B. R. Wiggs, A. James, J. C. Hogg, and C. H. Bosken. 1991. The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 143:1189-1193.
10. Vincent. R., P. Goegan, G. Johnson, J. R. Brooke, P. Kumarathansan, L. Bouthillier, and R. T. Burnett. 1997. Regulation of promotor-CAT stress genes in HEPG2 cells by suspensions of particles from ambient air. Fundam. Appl. Toxicol. 39:18-32.
11. Bouthillier, L., R. Vincent, P. Goegan, I. Y. Adamson, S. Bjarnason, M. Stewart, J. Guenette, M. Potvin, and P. Kumarathasan. 1998. Acute effects of inhaled urban particles and ozone: lung morphology, macrophage activity, and plasma endothelm-1. Am. J. Pathol. 153:1873-1884.
12. Keeling, B., J. Hobson, and A. Churg. 1993. Effects of cigarette smoke on tracheal epithelial uptake of non-asbestos mineral particles in organ culture. Am. J. Respir. Cell Mol. Biol. 9:335-340.
13. Li, K., B. Keeling, and A. Churg. 1996. Mineral dusts cause collagen and elastin breakdown in the rat lung: a potential mechanism of dust-induced emphysema. Am. J. Respir. Crit. Care Med. 153:644-649.
14. Border, W. A., and N. A. Noble. 1994. Transforming growth factor β in tissue fibrosis. N. Engl. J. Med. 331:1286-1292.
15. 1: effects on growth and synthesis of glycosaminoglycans. Am. J. Physiol. 271:L910-L917.
16. 1 in tracheal explants exposed to amosite asbestos. Am. J. Respir. Cell Mol. Biol. 24:427-435.
17. Dai, J., C. Xie, and A. Churg. 2002. Iron loading makes a non-fibrogenic model air pollutant particle fibrogenic in rat tracheal explants. Am. J. Respir. Cell Mol. Biol. 26:685-693.
18. Tak, P. P., and G. S. Firestein. 200l. NF-κB: a key role in inflammatory diseases. J. Clin. Invest. 107:7-11.
19. Lin, Y. Z., S. Y. Yao, R. A. Veach, T. R. Rogerson, and J. Hawijer. 1995. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 270:14255-14258.
20. 10 occurs via an iron-mediated mechanism in the absence of IκB degradation. Toxicol. Appl. Pharmacol. 166:101-110.
21. Shulka, A., C. Timblin, K. BeruBe, T. Gordon, W. McKinney, K. Driscoll, P. Vacek, and B. T. Mossman. 2000. Inhaled particulate matter causes expression of nuclear factor (NF)-κB-related genes and oxidant-dependent NF-κB activation in vitro. Am. J. Respir. Cell Mol. Biol. 23:182-187.
22. Costa, D. L., and K. L. Dreher. 1997. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ. Health Perspect. 105:1053-1060.
23. Ghio, A. J., J. Steonheurner, L. A. Dailey, and J. D. Carter. 1999. Metals associated with both the water soluble and insoluble fractions of ambient air pollution particles catalyze an oxidative stress. Inhal. Toxicol. 11:37-49.
24. 10 filters from the Utah Valley on human airway epithelial cells. Am. J. Physiol. 277:L970-L967.
25. Quay, J. I., W. Reed, J. Samet, and R. B. Devlin. 1998. Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-κB activation. Am. J. Respir. Cell Mol. Biol. 19:98-106.
26. Ball, J. C., A. M. Straccia, W. C. Young, and A. E. Aust. 2000. The formation of reactive oxygen species catalyzed by neutral, aqueous extracts of NIST ambient particulate matter and diesel engine particles. J. Air Waste Manag. Assoc. 50:1897-1903.
27. Janssen-Heininger, Y. M., M. E. Poynter, and P. A. Baeuerle. 2000. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic. Biol. Med. 28:1317-1327.
28. Takizawa, H., T. Ohtoshi, S. Kawasaki, S. Abe, I. Sugawara, and K. Nakahara. 2000. Matsushima, K, Kudoh S. Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways. Respirology 5:197-203.
29. Hashimoto, S., Y. Gon, I. Takeshita, K. Matsumoto, I. Jibiki, H. Takizawa, S. Kudoh, and T. Horie. 2000. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am. J. Respir. Crit. Care Med. 161:280-285.
30. Abe, S., H. Takizawa, I. Sugawara, and S. Kudoh. 2000. Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro. Am. J. Respir. Cell Mol. Biol. 22:296-303.
31. Demetriou, M., C. Binkert, B. Sukhu, H. C. Tenenbraum, and J. W. Dennis. 1996. Fetuin/α2-HS glycoprotein is a transforming growth factor-β type II receptor mimic and cytokine antagonist. J. Biol. Chem. 271:12755-12761.
32. Rameshwar, P., R. Narayanan, J. Qian, T. N. Denny, C. Colon, and P. Gascon. 2000. NF-κB as a central mediator in the induction of TGF-β in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. J. Immunol. 165:2271-2277.
33. Lawrence, T., D. W. Gilroy, P. R. Colville-Nash, and W. A. Willoughby. 2001. Possible new role for NF-κB in the resolution of inflammation. Nat. Med. 7:1291-1297.
34. 1 induced fibroproliferative lung disease in two strains of mice. Am. J. Respir. Cell Mol. Biol. 27:705-713.
35. Perdue, T. D., and A. R. Brody. 1994. Distribution of transforming growth factor-beta 1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats. J. Histochem. Cytochem. 42:1061-1070.