Lithium augmentation therapy in refractory depression - Update 2002

European Archives of Psychiatry and Clinical Neuroscience

Volumn 253, Issue 3, 2003, Pages 132-139

  Bauer, Michael ^c   Forsthoff, Anna ^a   Baethge, Christopher ^b   Adli, Mazda ^c   Berghöfer, Anne ^c   Döpfmer, Susanne ^c   Bschor, Tom ^d  

^a UNIVERSITY OF MUNICH   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Lithium augmentation; Major depression; Refractory depression; Response prediction; Treatment resistant depression

Indexed keywords

ANTIDEPRESSANT AGENT; LITHIUM; LITHIUM CARBONATE;

ADULT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; TREATMENT OUTCOME; COMPARATIVE STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; INSTRUMENTATION; MEDLINE; META ANALYSIS; MIDDLE AGED; NEUROSECRETION; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; RECURRENT DISEASE; STATISTICS;

ADULT; ANTIDEPRESSIVE AGENTS; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LITHIUM; MALE; MEDLINE; META-ANALYSIS; MIDDLE AGED; NEUROSECRETORY SYSTEMS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; RECURRENCE;

EID: 0042328261     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-003-0430-9     Document Type: Review

References (63)

1. Adli M, Berghöfer A, Linden M, Helmchen H, Mü ller-Oerlinghausen B, Mackert A, Stamm T, Bauer M (2002) Effectiveness and feasibility of a standardized stepwise drug treatment regimen algorithm for inpatients with depressive disorders: results of a two-year observational algorithm study. J Clin Psychiatry 63:782-790
2. Adli M, Bschor T, Canata B, Döpfmer S, Bauer M (1998) Lithium in the treatment of acute depression. [Article in German] Fortschr Neurol Psychiatr 66:435-441
3. Alvarez E, Pérez-Solá V, Pérez-Blanco J, Queraltó JM, Torrubia R, Noguera R (1997) Predicting outcome of lithium added to antidepressants in resistant depression. J Affect Disord 42:179-186
4. Amsterdam JD, Winokur A, Abelman E, Lucki I, Rickels K (1983) Cosyntropin (ACTH alpha 1-24) stimulation test in depressed patients and healthy subjects. Am J Psychiatry 140:907-909
5. Barden N, Reul JM, Holsboer F (1995) Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 18:6-11
6. Bauer M (1995) The combined use of lithium and SSRIs. J Serotonin Res 2:69-76
7. Bauer M,Bschor T, Kunz D, Berghöfer A, Ströhle A, Müller Oerlinghausen B (2000) Double-blind, placebo-controlled trial of the use of lithium to augment antidepressant medication in continuation treatment of unipolar major depression. Am J Psychiatry 157:1429-1435
8. Bauer M, Döpfmer S (1999) Lithium augmentation in treatment-resistant depression: meta-analysis of placebo-controlled studies. J Clin Psychopharmacol 19:427-434
9. Bauer M, Whybrow PC, Angst J, Versiani M, Möller HJ (2002a) World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, Part 1: Acute and continuation treatment of major depressive disorder. World J Biol Psychiatr 3:5-43
10. Bauer M, Whybrow PC, Angst J, Versiani M, Möller HJ (2002b) World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, Part 2: Maintenance treatment of major depressive disorder and treatment of chronic depressive disorders and subthreshold depressions. World J Biol Psychiatr 3:67-84
11. Baumann P, Nil R,Souche A, Montaldi S, Baettig D, Lambert S, Uehlinger C, Kasas A, Amey M, Jonzier-Perey M (1996) A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: A clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol 16:307-314
12. Bech P, Rafaelsen OJ (1986) The melancholia scale: development, consistency, validity and utility. In: Sartorius N, Ban PA (eds) Assessment of depression. Springer, Berlin Heidelberg New York, pp 259-269
13. Browne M, Lapierre YD, Hrdina PD, Horn E (1990) Lithium as an adjunct in the treatment of major depression. Int Clin Psychopharmacol 5:103-110
14. Bschor T, Adli M, Baethge C, Eichmann U, Ising M, Uhr M, Modell S, Künzel H, Müller-Oerlinghausen B, Bauer M (2002a) Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depression. Neuropsychopharmacol 27:470-478
15. Bschor T, Baethge C, Adli M, Eichmann U, Ising M, Uhr M, Modell S, Künzel H, Müller-Oerlinghausen B, Bauer M (2003) Association between response to lithium augmentation and the combined DEX/CRH test in major depressive disorder. J Psychiatr Res 37:135-143
16. Bschor T, Baethge C, Adli M, Lewitzka U, Eichmann U, Bauer M (2003) Hypothalamic-pituitary-thyroid system activity during lithium augmentation in unipolar major depression. J Psychiatr & Neuroscience 28:210-216
17. Bschor T, Berghöfer A, Ströhle A, Kunz D, Adli M, Müller-Oerlinghausen B, Bauer M (2002b) How long should the lithium augmentation strategy be maintained? A 1-year follow-up of a placebo-controlled study in unipolar refractory major depression. J Clin Psychopharmacol 22:427-430
18. Bschor T, Canata B, Müller-Oerlinghausen B, Bauer M (2001) Predictors of response to lithium augmentation in tricyclic antidepressant-resistant depression. J Affect Disorders 64:261-265
19. Delgado PL, Price LH, Charney DS, Heninger GR (1988) Efficacy of fluvoxamine in treatment refractory depression. J Affect Disorder 15:55-60
20. De Montigny C (1994) Lithium addition in treatment-resistant depression. Int Clin Psychopharmacol 9 (Suppl 2):31-35
21. De Montigny C, Aghajanian GK (1978) Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science 202:1303-1306
22. De Montigny C, Cournoyer G, Morisette R (1983) Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression: correlations with the neurobiologic actions of tricyclic antideoressant drugs and lithium on the serotonin system. Arch Gen Psychiatry 40:1327-1334
23. De Montigny C, Elie R, Caille G (1985) Rapid response to the addition of lithium in iprindole-resistant unipolar depression: a pilot study. Am J Psychiatry 142:220-223
24. De Montigny C, Grunberg F, Mayer A, Deschenes JP (1981) Lithium induces rapid relief of depression in tricyclic antidepressant drug non-responders. Br J Psychiatry 138:252-256
25. Dinan TG (1993) Lithium augmentation in sertraline-resistant depression: a preliminary dose-response study. Acta Psychiatr Scand 88:300-301
26. Dinan TG (1997) Neuroendocrinology of mood disorders. Curr Opin Psychiatry 10:84-87
27. Dinan TG, Barry S (1989) A comparison of electroconvulsive therapy with a combined lithium and tricyclic combination among depressed tricyclic nonresponders. Acta Psychiatr Scand 80:97-100
28. Fava M, Alpert J, Nierenberg A, Lagomasino I, Sonawalla S, Tedlow J, Worthington J, Baer L, Rosenbaum JF (2002) Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine. J Clin Psychopharmacol 22:379-387
29. Fava M, Rosenbaum JF, McGrath PJ, Stewart JW, Amsterdam JD, Quitkin FM (1994) Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study. Am J Psychiatry 151:1372-1374
30. Fieve RR, Peselow ED (1994) Lithium: clinical applications. In: Burrows GD (ed) Psychiatry Series. Elsevier, Amsterdam, pp 277-321
31. Flint AJ, Rifat SL (1994) A prospective study of lithium augmentation in antidepressant-resistant geriatric depression. J Clin Psychopharmacol 14:353-356
32. Fontaine R, Ontiverod A, Elie R, Vézina M (1991) Lithium carbonate augmentation of desipramine and fluoxetine in refractory depression. Biol Psychiatry 29:946-948
33. Hawley CJ, Roberts AG, Baldwin DS (1994a) Tolerability of combined treatment with lithium and fluoxetine: 14 cases treated under open conditions. Int Clin Psychopharmacol 9:31-33
34. Hawley CJ, Roberts AG, Walker MH (1994b) Tolerability of combined treatment with lithium and paroxetine: 19 cases treated under open conditions. Int Clin Psychopharmacol 8:266-267
35. Heninger GR, Charney DS, Sternberg DE (1983) Lithium carbonate augmentation of antidepressant treatment. Arch Gen Psychiatry 40:1335-1342
36. Heit S, Nemeroff CB (1998) Lithium augmentation of antidepressants in treatment-refractory depression. J Clin Psychiatry 59 (suppl 6):28-33
37. Heuser IJE, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Dettling M, Yassouridis A, Holsboer F (1996) Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry 153:93-99
38. Hoencamp E, Haffmans PMJ, Dijken WA (1994) Brofaromine versus lithium addition to maprotiline: a double blind study in maprotiline refractory depressed outpatients. J Affect Disord 30:219-227
39. Hoencamp E, Haffmans PMJ, Dijken WA, Huijbrechts IPAM (2000) Lithium augmentation of venlafaxine: an open-label trial. J Clin Psychiatry 20:538-543
40. Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacol 23:477-501
41. Holsboer F, Lauer Ch J, Schreiber W, Krieg JC (1995) Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology 62:340-347
42. Joffe RT, Levitt AJ, Bagby RM, MacDonald C, Singer W (1993a) Predictors of response to lithium and triiodothyronine augmentation of antidepressants in tricyclic non-responders. Br J Psychiatry 163:574-578
43. Joffe RT, Singer W, Levitt AJ, MacDonald C (1993b) A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression. Arch Gen Psychiatry 50:387-393
44. Kantor D, McNevin S, Leichner P, Harper D, Krenn M (1986) The benefit of lithium carbonate adjunct in refractory depression - factor or fiction? Can J Psychiatry 31:416-418
45. Katona CLE, Abou-Saleh MT, Harrison DA, Nairac BA, Edwards DRL, Lock T, Burns RA, Robertson MM (1995) Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine. Br J Psychiatry 166:80-86
46. Mendels J (1976) Lithium in the treatment of depression. Am J Psychiatry 133:373-378
47. Möller HJ, Fischer G, Zerssen vD (1987) Prediction of therapeutic response in acute treatment with antidepressants. Results of an empirical study involving 159 endogenous depressive patients. Eur Arch Psychiatr Neurol Sci 236:349-357
48. Müller-Oerlinghausen B, Berghöfer A, Bauer M (2002) Bipolar disorder. Lancet 359:241-247
49. Nierenberg AA, Amsterdam JD (1990) Treatment-resistant depression: definition and treatment approaches. J Clin Psychiatry 51 (suppl 6):39-47
50. Paykel ES (1994) Epidemiology of refractory depression. In: Nolen WA, Zohar J, Roose SP, Amsterdam JD (eds) Refractory Depression. Current Strategies and Future Directions. London: John Wiley & Sons Ltd, pp 3-17
51. Price LH, Charney DS, Henninger GR (1986) Variability of response to lithium augmentation in refractory depression. Am J Psychiatry 143:1387-1392
52. Rouillon F, Gorwood P (1998) The use of lithium to augment antidepressant medication. J Clin Psychiatry 59 (suppl 5):32-39
53. Rybakowski J, Matkowski K (1992) Adding lithium to antidepressant therapy: factors related to therapeutic potentiation. Eur Neuropsychopharmacol 2:161-165
54. Sangdee C, Franz DN (1978) Lithium-induced enhancement of 5-HT transmission at a central synapse. Comm Psychopharmacol 2:191-198
55. Schöpf J, Baumann P, Lemarchand T, Rey M (1989) Treatment of endogenous depressions resistant to tricyclic antidepressants or related drugs by lithium addition. Results of a placebo-controlled double-blind study. Pharmacopsychiatry 22:183-187
56. Scott J (1988) Chronic depression. Br J Psychiatry 153:287-297
57. Sluzeska A, Sobieska M, Rybakowski JK (1997) Changes in acute-phase proteins during lithium potentiation of antidepressants in refractory depression. Biol Psychiatry 35:123-127
58. Souza FG, Goodwin GM (1991) Lithium treatment and prophylaxis in unipolar depression: a meta-analysis. Br J Psychiatry 158:666-675
59. Stein G, Bernadt M (1993) Lithium augmentation therapy in tricyclic-resistant depression. A controlled trial using lithium in low and normal doses. Br J Psychiatry 162:634-640
60. Treiser SL, Cascio CS, O'Donohue TL, Keilar K (1981) Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Science 213:1529-1531
61. Uehlinger C, Nil R, Amey M, Baumann P, Dufour H (1995) Citalopram-lithium combination treatment of elderly depressed patients: a pilot study. Int J Ger Psychiatry 10:281-287
62. Zusky PM, Biederman J, Rosenbaum JF, Manschreck TC, Gross CC, Weilberg JB, Gastfriend DR (1988) Adjunct low dose lithium carbonate in treatment-resistant depression: a placebo-controlled study. J Clin Psychopharmacol 8:120-124
63. Zullino D, Baumann P (2001) Lithium augmentation in depressive patients not responding to selective serotonin reuptake inhibitors. Pharmacopsychiatry 34:119-127