Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia

Annals of Hematology

Volumn 72, Issue 4, 1996, Pages 280-285

  Kiefel, V ^a   Freitag, E ^a   Kroll, H ^a   Santoso, S ^a   Mueller Eckhardt, C ^a  

^a Inst Clin Immunol Transfus Med   (Germany)

Author keywords

AITP; Autoimmune diseases; Autoimmune thrombocytopenic purpura; MAIPA assay; Platelet antibodies; Thrombocytopenia

Indexed keywords

AUTOANTIBODY; EPITOPE; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; THROMBOCYTE ANTIBODY;

ARTICLE; AUTOIMMUNITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REMISSION; THROMBOCYTE ADHESION; THROMBOCYTOPENIC PURPURA;

AUTOANTIBODIES; AUTOIMMUNITY; BLOOD PLATELETS; HUMANS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBOCYTOPENIA;

EID: 0029867090     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050173     Document Type: Article

References (17)

1. Bordin JO, Smith JW, Horsewood P, Hayward CPM, Warkentin TE, Lee DH, Kelton JG (1994) Detection of platelet-associated autoantibodies to the GP-IIb/IIIa complex by direct radioimmunoprecipitation: a specific test for idiopathic thrombocytopenic purpura. Blood 84 [Suppl] 1:185a
2. George JN (1990) Platelet immunoglobulin G: its significance for the evaluation of thrombocytopenia and for understanding the origin of alpha-granule proteins. Blood 76:859-870
3. George JN (1991) Platelet IgG: measurement, interpretation, and clinical significance. In: Coller BS (ed) Progress in hemostasis and thrombosis, vol 10. Saunders, Philadelphia, pp 97-126
4. Harrington WJ, Sprague CC, Minnich V, Moore CV, Aulvin RC, Dubach R (1953) Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura. Ann Intern Med 38:433-469
5. Helmerhorst FM, Smeenk TJT, Hack CA, Engelfriet CP, von dem Borne AEGK (1983) Interference of IgG, IgG aggregates and immune complexes in tests for platelet autoantibodies. Br J Haematol 55:533-545
6. Hotchkiss AJ, Leissinger CA, Smith ME, Jordan JV, Kautz CA, Shulman NR (1986) Evaluation by quantitative acid elution and radioimmunoassay of multiple classes of immunoglobulins and serum albumin associated with platelets in idiopathic thrombocytopenic purpura. Blood 67:1126-1131
7. Kelton JG, Steeves K (1983) The amount of platelet-bound albumin parallels the amount of IgG on washed platelets from patients with immune thrombocytopenia. Blood 62:924-927
8. Kiefel V (1992) The MAIPA assay and its applications in immunohematology. Transfus Med 2:181-188
9. Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C (1987) Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet reactive antibodies. Blood 70:1722-1726
10. Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C (1991) Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura. Br J Haematol 79:256-262
11. McMillan R, Tani P, Millard F, Berchtold P, Renshaw L, Woods VL (1987) Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood 70:1040-1045
12. Reed AH, Henry RJ, Mason WB (1971) Influence of statistical method used on the resulting estimate of normal range. Clin Chem 17:275-284
13. Sachs L (1984) Applied statistics. A handbook of techniques, 2nd edn. Springer, Berlin Heidelberg New Yok
14. Schneider W, Schnaidt M (1981) The platelet adhesion immunofluorescence test: a modification of the platelet suspension immunofluorescence test. Blut 43:389-392
15. Shulman NR, Marder VJ, Weinrach RS (1965) Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura. Physiologic, serologic and isotopic studies. Ann NY Acad Sci 124:499-542
16. Tomiyama Y, Take H, Honda S, Furubayashi T, Mizutani H, Tsubakio T, Kurata Y (1990) Demonstration of platelet antigens that bind platelet-associated autoantibodies in chronic ITP by direct immunoprecipitation procedure. Br J Haematol 75:92-98
17. von dem Borne AEGK, Verheugt FWA, Oosterhof F, von Riesz E, Brutel de la Reviere A, Engelfriet CP (1978) A simple immunofluorescence test for the detection of platelet antibodies. Br J Haematol 39:195-207