Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures

Laboratory Investigation

Volumn 83, Issue 7, 2003, Pages 1025-1032

  Yepes, Manuel ^a,b   Moore, Elizabeth ^a   Brown, Sharron A N ^a   Hanscom, Heather N ^a   Smith, Elizabeth P ^a   Lawrence, Daniel A ^a,b   Winkles, Jeffrey A ^a,b  

^a HOLLAND LABORATORY   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; ANK PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PYROPHOSPHATE; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CALCIFICATION; CELL DEATH; CEREBELLUM; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DENDRITE; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEMBRANE DEPOLARIZATION; MESENCEPHALON; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PERIKARYON; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; RAT; SPINAL CORD; THALAMUS;

ADULT; ANIMALS; ANTIBODY SPECIFICITY; BLOTTING, NORTHERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOENZYME TECHNIQUES; KAINIC ACID; LIMBIC SYSTEM; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; NEURONS; PHOSPHATE TRANSPORT PROTEINS; RATS; RNA, MESSENGER; SEIZURES;

EID: 0042308357     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000075640.49586.E6     Document Type: Article

References (23)

1. Bacskai BJ, Xia MQ, Strickland DK, Rebeck GW, and Hyman BT (2000). The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci USA 97:11551-11556.
2. Blume W (1992). Motor system: Anatomy, physiology and epileptogenesis. In: Willye E, editor. The treatment of epilepsy. Baltimore: Williams and Wilkins, 82-92.
3. Chapman AG, Meldrum BS, and Siesjo BK (1977). Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem 28:1025-1035.
4. Coulter DA (1999). Chronic epileptogenic cellular alterations in the limbic system after status epilepticus. Epilepsia 40(Suppl 1):S23-S33.
5. Guo Y, Hsu DKW, Feng SY, Richards CM, and Winkles JA (2002). Polypeptide growth factors and phorbol ester induce progressive ankylosis (ank) gene expression in murine and human fibroblasts. J Cell Biochem 84:27-38.
6. Harris KM (1999). Structure, development, and plasticity of dendritic spines. Curr Opin Neurobiol 9:343-348.
7. Harris KM and Kater SB (1994). Dendritic spines: Cellular specializations imparting both stability and flexibility to synaptic function. Annu Rev Neurosci 17:341-371.
8. Heinemann U, Buchheim K, Gabriel S, Kann O, Kovacs R, and Schuchmann S (2002). Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus. Prog Brain Res 135:197-210.
9. Ho AM, Johnson MD, and Kingsley DM (2000). Role of the mouse ank gene in control of tissue calcification and arthritis. Science 289:265-270.
10. Meighan-Mantha RL, Hsu DKW, Guo Y, Brown SAN, Feng SY, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, and Winkles JA (1999). The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem 274:33166-33176.
11. Meldrum BS (2002). Concept of activity-induced cell death in epilepsy: Historical and contemporary perspectives. Prog Brain Res 135:3-11.
12. Meldrum BS and Corsellis JAN (1992). Epilepsy. In: Adams JH, Corsellis JAN, and Duchen LW, editors. Greenfield's neuropathology. New York: John Wiley and Sons, 921-950.
13. Nociti FH Jr, Berry JE, Foster BL, Gurley KA, Kingsley DM, Takata T, Miyauchi M, and Somerman MJ (2002). Cementum: A phosphate-sensitive tissue. J Dent Res 81:817-821.
14. Nurnberg P, Thiele H, Chandler D, Hohne W, Cunningham ML, Ritter H, Leschik G, Uhlmann K, Mischung C, Harrop K, Goldblatt J, Borochowitz ZU, Kotzot D, Westermann F, Mundlos S, Braun HS, Laing N, and Tinschert S (2001). Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet 28:37-41.
15. Pendleton A, Johnson MD, Hughes A, Gurley KA, Ho AM, Doherty M, Dixey J, Gillet P, Loeuille D, McGrath R, Reginato A, Shiang R, Wright G, Netter P, Williams C, and Kingsley DM (2002). Mutations in ANKH cause chondrocalcinosis. Am J Hum Genet 71:933-940.
16. Reichenberger E, Tiziani V, Watanabe S, Park L, Ueki Y, Santanna C, Baur ST, Shiang R, Grange DK, Beighton P, Gardner J, Hamersma H, Sellars S, Ramesar R, Lidral AC, Sommer A, Raposo do Amaral CM, Gorlin RJ, Mulliken JB, and Olsen BR (2001). Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK. Am J Hum Genet 68:1321-1326.
17. Russell RG (1976). Metabolism of inorganic pyrophosphate (PPi). Arthritis Rheum 19(Suppl 3):465-478.
18. Ryan LM (2001). The ank gene story. Arthritis Res 3:77-79.
19. Sohn P, Crowley M, Slattery E, and Serra R (2002). Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone. Osteoarthritis Cartilage 10:482-490.
20. Somjen GG, Aitken PG, Giacchino JL, and Mcnamara JO (1986). Interstitial ion concentrations and paroxysmal discharges in hippocampal formation and spinal cord. Adv Neurol 44:663-680.
21. Tam JP (1988). Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci USA 85:5409-5413.
22. Terkeltaub RA (2001). Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281:C1-C11.
23. Yepes M, Sandkvist M, Coleman TA, Moore E, Wu JY, Mitola D, Bugge TH, and Lawrence DA (2002). Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest 109:1571-1578.