Elution of Metronidazole and Gentamicin from Polymethylmethacrylate Beads

Veterinary Surgery

Volumn 32, Issue 3, 2003, Pages 251-261

  Ramos, Jose R ^b   Howard, Rick D ^a   Pleasant, R Scott ^b   Moll, H David ^b   Blodgett, Dennis J ^b   Magnin, Geraldine ^b   Inzana, Thomas J ^b  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GENTAMICIN; METRONIDAZOLE; POLY(METHYL METHACRYLATE); ANTIINFECTIVE AGENT; BONE CEMENT;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG SCREENING; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; POLYMERIZATION; ANIMAL; ANIMAL DISEASE; BACTEROIDES FRAGILIS; BONE INFECTION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECT; DRUG STORAGE; ESCHERICHIA COLI; MICROBIOLOGICAL EXAMINATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTEROIDES FRAGILIS; BONE CEMENTS; BONE DISEASES, INFECTIOUS; DELAYED-ACTION PREPARATIONS; DRUG STORAGE; ESCHERICHIA COLI; GENTAMICINS; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; POLYMETHYL METHACRYLATE;

EID: 0042266713     PISSN: 01613499     EISSN: None     Source Type: Journal    
DOI: 10.1053/jvet.2003.50024     Document Type: Article

References (46)

1. Henry SL, Hood GA, Seligson D: Long-term implantation of gentamicin-polymethylmethacrylate antibiotic beads. Clin Orthop 295:47-53, 1993
2. Henry SL, Seligson D, Mangino P, et al: Antibiotic-impregnated beads, Part 1: Bead implantation versus systemic therapy. Orthop Rev 20:242-247, 1991
3. Holcombe SJ, Schneider RK, Bramlage LR, et al: Use of antibiotic-impregnated polymethylmethacrylate in horses with open or infected fractures or joints: 19 cases (1987-1995). J Am Vet Med Assoc 211:889-893, 1997
4. Butson RJ, Schramme MC, Garlick MH, et al: Treatment of intrasynovial infection with gentamicin-impregnated polymethylmethacrylate beads. Vet Rec 138:460-464, 1996
5. Trostle SS, Hendrickson DA, Stone WC, et al: Use of antimicrobial- impregnated polymethylmethacrylate beads for treatment of chronic, refractory septic arthritis and osteomyelitis of the digit in a bull. J Am Vet Med Assoc 208:404-407, 1996
6. Hirsh DC, Jang SS: Antimicrobic susceptibility of bacterial pathogens from horses. Vet Clin North Am Equine Pract 3:181-190, 1987
7. Snyder JR, Pascoe JR, Hirsh DC: Antimicrobial susceptibility of microorganisms isolated from equine orthopedic patients. Vet Surg 16:197-201, 1987
8. Schneider RK, Bramlage LR, Moore RM, et al: A retrospective study of 192 horses affected with septic arthritis/ tenosynovitis. Equine Vet J 24:436-442, 1992
9. Bowyer GW, Cumberland N: Anitbiotic release from impregnated pellets and beads. J Trauma 36:331-335, 1994
10. Ethell MT, Bennett RA, Brown MP, et al: In vitro elution of gentamicin, amikacin and ceftiofur from polymethylmethacrylate and hydroxyapatite cement. Vet Surg 29:375-382, 2000
11. Miclau T, Dahners LE, Lindsey RW: In vitro pharmacokinetics of antibiotic release from locally implantable materials. J Orthop Res 11:627-632, 1993
12. Picknell B, Mizen L, Sutherland R,: Antibacterial activity of antibiotics in acrylic bone cement. J Bone Joint Surg 59-B:302-307, 1977
13. Venkateshwaran TG, Stewart JT: Determination of metronidazole in vaginal tissue by high performance liquid chromatography using solid-phase extraction. J Chromatogr B Biomed Sci Appl 672:300-304, 1995
14. Stead DA, Richards RME: Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 675:295-302, 1996
15. Stead DA, Richards RME: Sensitive high-performance liquid chromatographic assay for aminoglycosides in biological matrices enables the direct estimation of bacterial drug uptake. J Chromatogr B Biomed Sci Appl 693:415-421, 1997
16. ANSI. Methods for antimicrobial susceptibility testing of anaerobic bacteria (ed 2). National Committee for Clinical Laboratory Standards M11-A2 10:1-23, 1991
17. ANSI. Susceptibility tests for bacteria isolated from animals. National Committee for Clinical Laboratory Standards M31-A 19:16-25, 1999
18. Wilson KJ, Cierny G, Adams KR, et al: Comparative evaluation of the diffusion of tobramycin and cefatoxime out of AIPMMA beads. J Orthop Res 6:279-286, 1988
19. Hirsh DC, Indiveri MC, Jang SS: Changes in prevalence and susceptibility of obligate anaerobes in clinical veterinary practice. J Am Vet Med Assoc 186:1086-1089, 1985
20. Casciato DA, Stewart PR, Rosenblatt JE: Growth curves of anaerobic bacteria in solid media. Appl Microbiol 29:610-614, 1975
21. Claus GW: Understanding microbes, New York, NY, WH Freeman, pp 167-174, 1989
22. Calhoun JH, Mader JT: Antibiotic beads in the management of surgical infections. Am J Surg 157:443-448, 1989
23. Baker AS, Greenham LW: Release of gentamicin from acrylic bone cement: elution and diffusion studies. J Bone Joint Surg Am 70-A:1551-1557, 1988
24. Marks KE, Nelson CL, Lautenschlager EP: Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg 58:358-364, 1976
25. Tripell SB: Current concepts review. Antibiotic-impregnated cement in total joint arthroplasty. J Bone Joint Surg 68-A: 1297-1302, 1986
26. Flick AB, Herbert JC, Goodell J, et al: Non-commercial application of AIPMMA beads. Technical note. Clin Orthop 223:282-286, 1987
27. Penner MJ, Masri BA, Duncan CP: Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty 11:939-944, 1996
28. Kuechle DK, Landon GC, Musher DM, et al: Elution of vancomycin, daptomycin, and amikacin from acrylic bone cement. Clin Orthop 264:302-308, 1991
29. Gupta BS, Wolf KW, Postlethwait RW: Effect of suture material and construction on frictional properties of sutures. Surg Gynecol Obstet 161:12-16, 1985
30. Kanellakopoulou K, Giamarellos-Bourboulis EJ: Carrier systems for the local delivery of antibiotics in bone infections. Drugs 59:1223-1232, 2000
31. Cierny GIII, Mader JT, Penninck JJ: A clinical staging system for adult osteomyelitis. Contemp Orthop 10:17-37, 1985
32. Farnsworth KD, WhiteII NA, Robertson J: The effect of implanting gentamicin-impregnated polymethylmethacrylate beads in the tarsocrural joint of the horse. Vet Surg 30:126-131, 2001
33. Katz S, Izhar M, Mirelman D: Bacterial adherence to surgical sutures. A possible factor in suture induced infection. Ann Surg 194:35-41, 1981
34. Osterberg B: Influence of capillary multifilament sutures on the antibacterial action of inflammatory cells in infected wounds. Acta Chir Scand 149:751-757, 1983
35. Scher KS, Bernstein JM, Jones CW: Infectivity of vascular sutures. Am Surg 51:577-579, 1985
36. Tobias KM, Schneider RK, Besser TE: Use of antimicrobial-impregnated polymethylmethacrylate. J Am Vet Med Assoc 208:841-845, 1996
37. Moore RM, Schneider RK, Kowalski J, et al: Antimicrobial susceptibility of bacterial isolates from 233 horses with musculoskeletal infection during 1979-1989. Equine Vet J 24:450-456, 1992
38. Moore RM: Pathogenesis of obligate anaerobic bacterial infections in horses. Compend Contin Educ Pract Vet 15:278-286, 1993
39. Sweeney RW, Sweeney CR, Soma LR, et al: Pharmacokinetics of metronidazole given to horses by intravenous and oral routes. Am J Vet Res 47:1726-1729, 1986
40. Sweeney RW, Sweeney CR, Weiher J: Clinical use of metronidazole in horses: 200 cases (1984-1989). J Am Vet Med Assoc 198:1045-1048, 1991
41. Kanoe M, Hirabayashi T, Anzai T, et al: Isolation of obligate anaerobic and some other bacteria from equine purulent lesions. Br Vet J 144:374-378, 1988
42. Adamson PJW, Wilson WD, Hirsh DC, et al: Susceptibility of equine bacterial isolates to antimicrobial agents. Am J Vet Res 46:447-450, 1985
43. Barclay ML, Begg EJ: Aminoglycoside adaptive resistance: importance for effective dosage regimens. Drugs 61:713-721, 2001
44. Barclay ML, Begg EJ, Chambers ST: Adaptive resistance following single doses of gentamicin in a dynamic in vitro model. Antimicrob Agents Chemother 36:1951-1957, 1992
45. Daikos GL, Jackson GG, Lolans VT, et al: Adaptive resistance to aminoglycoside antibiotics from first-exposure downregulation. J Infect Dis 162:414-420, 1990
46. Karlowsky JA, Zelenitsky SA, Zhanel GG: Aminoglycoside adaptive resistance. Pharmacotherapy 17:549-555, 1997