Natural peptide antibiotics from tunicates: Structures, functions and potential uses

Integrative and Comparative Biology

Volumn 43, Issue 2, 2003, Pages 313-322

  Lehrer, Robert I ^a   Tincu, J Andrew ^b   Taylor, Steven W ^b,c   Menzel, Lorenzo P ^a   Waring, Alan J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Migenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCIDIA; CLAVA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PLEURONECTOIDEI; PSEUDOPLEURONECTES AMERICANUS; STAPHYLOCOCCUS AUREUS; STYELA CLAVA; UROCHORDATA;

EID: 0042203502     PISSN: 00031569     EISSN: None     Source Type: Journal    
DOI: 10.1093/icb/43.2.313     Document Type: Conference Paper

References (32)

1. Amiche, M., F. Ducancel, A. Mor, J. C. Boulain, A. Menez, and P. Nicolas. 1994. Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins. J. Biol. Chem. 269:17847-17852
2. Babior, B. M. 1999. NADPH oxidase: An update. Blood 93:1464-1476.
3. Ballarin, L., F. Cima, and A. Sabbadin. 1998. Phenoloxidase and cytotoxicity in the compound ascidian Botryllus schlosseri. Dev. Comp. Immunol. 22:479-492.
4. Bartl, S., M. A. Baish, M. F. Flajnik, and Y. Ohta. 1997. Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response. J. Immunol. 159:6097-6104.
5. Bekker, L. G., S. Freeman, P. J. Murray, B. Ryffel, and G. Kaplan. 2001. TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase- independent pathways. J. Immunol. 166:6728-6734.
6. Cammarata, M., V. Arizza, N. Parrinello, G. Candore, and C. Caruso. 1997. Phenoloxidase-dependent cytotoxic mechanism in ascidian (Styela plicata) hemocytes active against erythrocytes and K562 tumor cells. Eur. J. Cell Biol. 74:302-307.
7. Clark, D. P., S. Durell, W. L. Maloy, and M. Zasloff. 1994. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J. Biol. Chem. 269:10849-10855.
8. Cowland, J. B., A. H. Johnsen, and N. Borregaard. 1995. hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules. FEBS Lett. 368:173-176.
9. Hancock, R. E. and R. I. Lehrer. 1998. Cationic peptides: A new source of antibiotics. Trends Biotechnol. 16:82-88.
10. Klebanoff, S. J. 1999. Myeloperoxidase. Proc. Assoc. Am. Physicians. 111:383-389.
11. Lee, I. H., C. Zhao, Y. Cho, S. S. Harwig, E. L. Cooper, and R. I. Lehrer. 1997a. Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes. FEBS Lett. 400:158-162.
12. Lee, I. H., Y. Cho, and R. I. Lehrer. 1997b. Styelins, broad-spectrum antimicrobial peptides from the solitary tunicate, Styela clava. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 118:515-521.
13. Lee, I. H., Y. Cho, and R. I. Lehrer. 1997c. Effects of pH and Salinity on the Antimicrobial Properties of Clavanins. Infect. Immun. 65:2898-2903.
14. Lee, I. H., C. Zhao, T. Nguyen, L. Menzel, A. J. Waring, M. A. Sherman, and R. I. Lehrer. 2001. Clavaspirin, an antibacterial and haemolytic peptide from Stvela clava. J. Peptide Res. 58:445-456.
15. Lee, S. S., D. Fitch, M. F. Flajnik, and E. Hsu. 2000. Rearrangement of immunoglobulin genes in shark germ cells. J. Exp. Med. 191:1637-1648.
16. Lehrer, R. I., A. K. Lichtenstein, and T. Ganz. 1993. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11:105-128.
17. Lehrer, R. I., D. Szklarek, A. Barton, T. Ganz, K. J. Hamann, and G. J. Gleich. 1989. Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J. Immunol. 142:4428-4434.
18. Menzel, L. P., I. H. Lee, B. Sjostrand, and R. I. Lehrer. 2002. Immunolocalization of clavanins in Styela clava hemocytes. Dev. Comp. Immunol. 26:505-515.
19. Murray, H. W. and C. F. Nathan. 1999. Macrophage microbicidal mechanisms in vivo: Reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 189:741-746.
20. Nathan, C. and M. U. Shiloh. 2000. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. U.S.A. 97:8841-8848.
21. Nauseef, W. M. 1999. The NADPH-dependent oxidase of phagocytes. Proc. Assoc. Am. Physicians 111:373-382.
22. Orlov, D., T. Hong, L. P. Menzel, R. Azimov, T. J. Falla, A. J. Waring, and R. I. Lehrer. 2002. Bactericidal Mechanism of Iseganan (IB-367), a Rapidly Acting Antimicrobial Protegrin Peptide. Abstracts of the 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract C1-1805, page 99.
23. Sawada, T., J. Zhang, and E. L. Cooper. 1993. Classification and characterization of hemocytes in Styela Clava. Biol. Bull. 184:84-96.
24. Taylor, S. W., A. G. Craig, W. H. Fischer, M. Park, and R. I. Lehrer. 2000. Styelin D, an extensively modified antimicrobial peptide from ascidian hemocytes. J. Biol. Chem. 275:38417-38426.
25. Taylor, S. W., B. Kammerer, G. J. Nicholson, K. Pusecker, T. Walk, E. Bayer, S. Scippa, and M. de Vincentiis. 1997. Morulin Pm: a modified polypeptide containing TOPA and 6-bromotryptophan from the morula cells of the ascidian, Phallusia mammillatu. Arch. Biochem. Biophys. 348:278-288.
26. Taylor, S. W., M. M. Ross, and J. H. Waite. 1995. Novel 3,4-di- and 3,4,5-trihydroxyphenylalanine-containing polypeptides from the blood cells of the ascidians Ascidia ceratodes and Molgula manhattensis. Arch. Biochem. Biophys. 324:228-240.
27. Wardman, P. and L. P. Candeias. 1996. Fenton chemistry: An introduction. Radiat. Res. 145:523-531.
28. Weiss, S. J., M. B. Lampert, and S. T. Test. 1983. Long-lived oxidants generated by human neutrophils: Characterization and bioactivity. Science 222:625-628.
29. Zanetti, M., R. Gennaro, and D. Romeo. 1995. Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett. 374:1-5.
30. Zhao, C., L. Liaw, I. H. Lee, and R. I. Lehrer. 1997c. cDNA cloning of Clavanins: Antimicrobial peptides of tunicate hemocytes. FEBS Lett. 410:490-492.
31. Zhao, C., L. Liaw, I. H. Lee, and R. I. Lehrer. 1997b. cDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate, Styela clava. FEBS Lett. 412:144-148.
32. Zhao, C., T. Nguyen, L. Liu, R. E. Sacco, K. A. Brogden, and R. I. Lehrer. 2001. Gallinacin-3, an inducible epithelial beta-defensin in the chicken. Infect. Immun. 69:2684-2691.