Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide

Nitric Oxide - Biology and Chemistry

Volumn 8, Issue 4, 2003, Pages 231-234

  Johnston, Brian D ^a,b   DeMaster, Eugene G ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Curcumin; DEA NO; Nitric oxide; Nitrogen dioxide

Indexed keywords

CURCUMIN; NITRIC OXIDE; NITRITE; NITROGEN DIOXIDE;

AQUEOUS SOLUTION; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; DRUG EFFECT; OXIDATION; PHYTOCHEMISTRY; PRIORITY JOURNAL; REDUCTION;

EID: 0042164584     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-8603(03)00030-2     Document Type: Article

References (25)

1. Ammon C.A.C., Wahl M.A. Pharmacology of Curcuma longa. Planta Med. 57:1991;1-7.
2. Araujo C.A., Leon L.L. Biological activities of Curcuma longa L. Mem. Inst. Oswaldo Cruz. 96:2001;723-728.
3. Inano H., Onoda M. Prevention of radiation-induced mammary tumors. Int. J. Radiat. Oncol. Biol. Phys. 52:2002;212-223.
4. Kunchandy E., Rao M.N.A. Effect of curcumin on hydroxyl radical generation through the Fenton reaction. Int. J. Pharmaceut. 57:1989;173-176.
5. Kunchandy E., Rao M.N.A. Oxygen radical scavenging activity of curcumin. Int. J. Pharmaceut. 58:1990;237-240.
6. Tonssen H.H., Greenhill J. Studies on curcumin and curcuminoids XXII, curcumin as a reducing agent and radical scavenger. Int. J. Pharmaceut. 87:1992;79-87.
7. Sreejayan, Rao M.N.A. Free radical scavenging activity of curcuminoids. Arsneimittelforschung. 46:1996;169-171.
8. Sugiyama Y., Kawakishi S., Osawa T. Involvement of the β-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin. Biochem. Pharmacol. 52:1996;519-525.
9. Srivastava R. Inhibition of neutrophil response by curcumin. Agents Actions. 28:1989;298-303.
10. Joe B., Lokesh B.R. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta. 1224:1994;255-263.
11. Chan M.M.Y., Huang H.I., Fenton M.R., Fong D. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55:1998;1955-1962.
12. Pan M.H., Lin-Shiau S.Y., Lin J.K. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages. Biochem. Pharmacol. 60:2000;1665-1676.
13. Reddy A.C., Lokesh B.R. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem. Toxicol. 32:1994;279-283.
14. Okada K., Wangpoengtrakul C., Tanaka T., Toyokuni S., Uchida K., Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J. Nutr. 131:2001;2090-2095.
15. Sreejayan, Rao M.N. Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49:1997;105-107.
16. Onoda M., Inano H. Effect of curcumin on the production of nitric oxide by cultured rat mammary gland. Nitric Oxide. 4:2000;505-515.
17. Unnikrishnan M.K., Rao M.N. Curcumin inhibits nitrogen dioxide induced oxidation of hemoglobin. Mol. Cell Biochem. 146:1995;35-37.
18. Challis B.C. The chemistry of formation of N-nitroso compounds. Gibson G.G., Ioannides C. Safety Evaluation of Nitrosatable Drugs and Chemicals. 1981;16-51 Taylor and Francis, London.
19. Wan Y.J., Pan M.H., Cheng A.L., Lin L.I., Ho Y.S., Hsieh C.Y., Lin J.K. Stability of curcumin in buffer solution and characterization of its degradation products. J. Pharm. Biomed. Anal. 15:1997;1867-1876.
20. Maragos C.M., Morley D., Wink D.A., Dunams T.M., Saavedra J.E., Hoffman A., Bove A.A., Isaac L., Hrabie J.A., Keefer L.K. Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J. Med. Chem. 34:1991;3242-3247.
21. Tristi-Firouzi M., DeMaster E.G., Quast B.J., Nelson D.P., Archer S.L. Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biological systems. J. Lab. Clin. Med. 131:1998;281-285.
22. Schrammel A., Koesling D., Schmidt K., Mayer B. Inhibition of purified soluble guanylate cyclase by L-ascorbic acid. Cardiovasc. Res. 47:2000;602-608.
23. Soliman K.F.A., Mazzio E.A. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc. Soc. Exp. Biol. Med. 218:1998;390-397.
24. Brouet I., Ohshima H. Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 206:1995;533-540.
25. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. 480-481:2002;243-268.