Parallel fiber receptive fields: A key to understanding cerebellar operation and learning

Cerebellum

Volumn 2, Issue 2, 2003, Pages 101-109

  Ekerot, Carl Fredrik ^a   Jörntell, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Golgi cells; Interneurons; Motor learning; Purkinje cells; Synaptic plasticity

Indexed keywords

CEREBELLUM; CEREBELLUM CORTEX; CLIMBING FIBER; GOLGI COMPLEX; INTERNEURON; LEARNING; MOSSY FIBER; MOTOR CONTROL; NERVE CELL PLASTICITY; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; RECEPTIVE FIELD; REVIEW; SYNAPSE; ANIMAL; BIOLOGICAL MODEL; HUMAN; LONG TERM POTENTIATION; PHYSIOLOGY; PURKINJE CELL;

ANIMALS; CEREBELLUM; HUMANS; INTERNEURONS; LEARNING; LONG-TERM POTENTIATION; MODELS, NEUROLOGICAL; NERVE FIBERS; PURKINJE CELLS;

EID: 0042162908     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220309411     Document Type: Review

References (66)

1. Oscarsson O. The sagittal organization of the cerebellar anterior lobe as revealed by the projection patterns of the climbing fibre system. In: Llinás R, editor, Neurobiology of Cerebellar Evolution and Development. Chicago: American Medical Association, 1969: 525-537.
2. Voogd J. The importance of fiber connections in the comparative anatomy of mammalian cerebellum. In: Llinás R, editor. Neurobiology of Cerebellar Evolution and Development. Chicago: American Medical Association, 1969: 493-514.
3. Ekerot C-F, Larson B. The dorsal spino-olivocerebellar system in the cat. II. Somatotopical organization. Exp Brain Res 1979; 36: 219-232.
4. Oscarsson O. Functional units of the cerebellum - sagittal zones and microzones. TINS 1979; 2: 143-145.
5. Voogd J, Bigaré F. Topographical distribution of olivary and cortico nuclear fibers in the cerebellum in the cat. In: Palay SL, Chan-Palay V, editors. The Cerebellum. New Vistas. Exp Brain Res (Suppl). Berlin, Heidelberg, New York: Springer Verlag, 1980; 6: 134-161.
6. Andersson G, Eriksson L. Spinal, trigeminal, and cortical climbing fibre paths to the lateral vermis of the cerebellar anterior lobe in the cat. Exp Brain Res 1981; 44: 71-81.
7. Trott JR, Apps R. Lateral and medial sub-divisions within the olivocerebellar zones of the paravermal cortex in lobule Vb/c of the cat anterior lobe. Exp Brain Res 1991; 87: 126-140.
8. Trott JR, Apps R. Zonal organization within the projection from the inferior olive to the rostral paramedian lobule of the cat cerebellum. Eur J Neurosci 1993; 5: 162-173.
9. Voogd J The Cerebellum of the Cat. Structure and Fibre Connexions. Thesis. Van Gorcum, Assen, 1964.
10. Ito M The Cerebellum and Neural Control. New York: Raven Press, 1984.
11. Oscarsson O. Functional organization of spino-cerebellar paths. In: Iggo A, editor. Handbook of Sensory Physiology, Vol. 2: Somatosensory System. Berlin, Heidelberg, New York: Springer Verlag, 1973: 339-380.
12. Miller S, Oscarsson O. Termination and functional organization of spinoolivarycerebellar paths, In: Fields WS, Willis WD, editors. Cerebellum in Health and Disease. St. Louis: WH Green Inc. 1970: 172-200.
13. Sugihara I, Wu H-S, Shinoda Y. The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to cerebellar compartmentalization. J Neurosci 2001; 21: 7715-7723.
14. Andersson G, Oscarsson O. Climbing fibre microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp Brain Res 1978; 32: 565-579.
15. Ekerot C-F, Garwicz M, Schouenborg J. Topography and nociceptive receptive fields of climbing fibres projecting to the cerebellar anterior lobe in the cat. J Physiol 1991; 441: 257-274.
16. Garwicz M, Apps R, Trott JR. Micro-organization of olivocerebellar and corticonuclear connections of the paravermal cerebellum in the cat. Eur J Neurosci 1996; 8: 2726-2738.
17. Sugihara I, Wu H-S, Shinoda Y. Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J Comp Neurol 1999; 414: 131-148.
18. Ekerot C-F, Jörntell H. Parallel fibre receptive fields of Purkinje cells and interneurones are climbing fibre specific. Eur J Neurosci 2001; 13: 1303-1310.
19. Garwicz M, Ekerot C-F. Topographical organization of the cerebellar cortical projection to nucleus interpositus anterior in the cat. J Physiol 1994; 474: 245-260.
20. Ekerot C-F, Jörntell H, Garwicz M. Functional relation between corticonuclear input and movements evoked on microstimulation in cerebellar nucleus interpositus anterior in the cat. Exp Brain Res 1995; 106: 365-376.
21. Ekerot C-F, Garwicz M, Jörntell H. The control of forelimb movements by intermediate cerebellum. In: De Zeeuw CI, Voogd J, Strata P. The Cerebellum: From Structure to Control. Prog Brain Res 1997; 114: 423-429.
22. Jörntell H Functional organization of cerebellar modules controlling forelimb movements: climbing and mossy fibre input and motor output via the red nucleus and motor cortex. PhD Thesis, 1997.
23. Cooke JD, Larson B, Oscarsson O, Sjölund B. Origin and termination of cuneocerebellar tract. Exp Brain Res 1971; 13: 339-358.
24. Cooke JD, Larson B, Oscarsson O, Sjölund B. Organization of afferent connections to cuneocerebellar tract. Exp Brain Res 1971; 13: 359-377.
25. Clendenin M, Ekerot C-F, Oscarsson O, Rosén I. Distribution in cerebellar cortex of mossy fibre afferents from the lateral reticular nucleus in the cat. Brain Res 1974; 69: 136-139.
26. Clendenin M, Ekerot C-F, Oscarsson O, Rosén I. Functional organization of two spinocerebellar paths relayed through the lateral reticular nucleus in the cat. Brain Res 1974; 69: 140-143.
27. Clendenin M, Ekerot C-F, Oscarsson O, Rosén I. The lateral reticular nucleus in the cat. I. Mossy fibre distribution in cerebellar cortex. Exp Brain Res 1974; 21: 473-486.
28. Clendenin M, Ekerot C-F, Oscarsson O. The lateral reticular nucleus in the cat. III. Organization of component activated from ipsilateral forelimb tract. Exp Brain Res 1974; 21: 501-513.
29. Gerrits NM, Voogd J, Nas WS. Cerebellar and olivary projections of the external and rostral internal cuneate nuclei in the cat. Exp Brain Res 1985; 57: 239-255.
30. Ekerot C-F, Larson B. Termination in overlapping sagittal zones in cerebellar anterior lobe of mossy and climbing fiber paths activated from dorsal funiculus. Exp Brain Res 1980; 38: 163-172.
31. Garwicz M, Jörntell H, Ekerot C-F. Cutaneous receptive fields of mossy fibres and climbing fibres projecting to cat cerebellar C3 zone. J Physiol 1998; 512: 277-293.
32. Sultan F. Distribution of mossy fibre rosettes in the cerebellum of cat and mice: evidence for a parasagittal organization at the single fibre level. Eur J Neurosci 2001; 13: 2123-2130.
33. Brand S, Dahl A-L, Mungaini E. The length of parallel fibres in the cat cerebellar cortex. An experimental light microscopic study. Exp Brain Res 1975; 252: 51-61.
34. Oscarsson O, Uddenberg N. Identification of a spinocerebellar tract activated from forelimb afferents in the cat. Acta Physiol Scand 1964; 62: 125-136.
35. Crichlow EC, Kennedy TT. Functional characteristics of neurones in the lateral reticular nucleus with reference to localized cerebellar potentials. Exp Neurol 1967; 18: 141-153.
36. Ekerot C-F. The lateral reticular nucleus in the cat. VII. Excitatory and inhibitory projection from the ipsilateral forelimb tract (iF tract). Exp Brain Res 1990; 79: 120-128.
37. Isope P, Barbour B. The majority of granule cell-Purkinje cell synapses are silent. Soc Neurosci Abstr 2001; 713: 5.
38. Wang SS, Khiroug L, Augustine GJ. Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc Natl Acad Sci USA 2000; 97: 8635-8640.
39. Jörntell H, Ekerot C-F. Reciprocal bi-directional plasticity of parallel fiber receptive fields in Purkinje cells and their afferent interneurons. Neuron 2002: in press.
40. Pitchitpomchai C, Rawson JA, Rees S. Morphology of parallel fibres in the cerebellar cortex of the rat: An experimental light and electron microscopic study with biocytin. J Comp Neurol 1994; 342: 206-220.
41. Ruigrok TJ, Cella F, Voogd J. Connections of the lateral reticular nucleus to the lateral vestibular nucleus in the rat. An anterograde tracing study with Phaseolus vulgaris leucoagglutinin. Eur J Neurosci 1995; 7: 1410-1413.
42. Eccles J, Ito M, Szentágothai J The Cerebellum as a Neuronal Machine. Berlin, Heidelberg, New York: Springer Verlag, 1967.
43. Ito M, Sakurai M, Tongroach P. Climbing fibre induced depression of both mossy fibre responses and glutamate sensitivity of cerebellar Purkinje cells. J Physiol 1982; 324: 113-134.
44. Ekerot C-F, Kano M. Long-term depression of parallel fibre synapses following stimulation of climbing fibres. Brain Res 1985; 342: 357-360.
45. Ito M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 2001; 81: 1143-1195.
46. Liao D, Hessler NA, Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 1995; 375: 400-404.
47. Durand GM, Kovalchuk Y, Konnerth A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 1996; 381: 71-75.
48. Llano I, Marty A, Armstrong CM, Konnerth A. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J Physiol 1991; 434: 183-213.
49. Batchelor AM, Garthwaite J. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature 1997; 385: 74-77.
50. Tempia F, Miniaci MC, Anchisi D, Strata P. Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells. J. Neurophysiol 1998; 80: 520-528.
51. Ekerot C-F, Jörntell H. Bi-directional synaptic plasticity of cutaneous parallel fibre input to Purkinje cells in the cerebellar cortex. Soc Neurosci Abstr 2001; 828: 6.
52. Jörntell H, Ekerot C-F. Bi-directional synaptic plasticity of cutaneous parallel fibre input to inhibitory interneurons in the cerebellar cortex Soc Neurosci Abstr 2001; 828: 5.
53. Kano M, Rexhausen U, Dreessen J, Konnerth A. Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells. Nature 1992; 356: 601-604.
54. Hirano T. Differential pre- and postsynaptic mechanisms for synaptic potentiation and depression between a granule cell and a Purkinje cell in rat cerebellar culture. Synapse 1991; 7: 321-323.
55. Salin PA, Malenka RC, Nicoll RA. cAMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron 1996; 16: 797-803.
56. Linden DJ, Ahn S. Activation of presynaptic cAMP-dependent protein kinase is required for induction of cerebellar long-term potentiation. J Neurosci 1999; 19: 10221-10227.
57. Gellman R, Gibson AR, Houk JC. Inferior olivary neurons in the awake cat: detection of contact and passive body displacement. J Neurophysiol 1985; 54: 40-60.
58. Gilbert PFC, Thach WT. Purkinje cell activity during motor learning. Brain Res 1997; 128: 309-328.
59. Andersson G, Armstrong DM. Complex spikes in Purkinje cells in the lateral vermis (b zone) of the cat cerebellum during locomotion. J Physiol 1987; 385: 107-134.
60. Kitazawa S, Kimura T, Yin PB. Cerebellar complex spikes encode both destinations and errors in arm movements. Nature 1998; 392: 494-497.
61. Ekerot C-F, Oscarsson O, Schouenborg J. Stimulation of cutaneous nociceptive C fibres causing tonic and synchronous activity in climbing fibres. J Physiol 1987; 386: 539-546.
62. Thompson RF, Kim JJ. Memory systems in the brain and localization of a memory. Proc Natl Acad Sci USA 1996; 93: 13438-13444.
63. Hesslow G, Svensson P, Ivarsson M. Learned movements elicited by direct stimulation of cerebellar mossy fiber afferents. Neuron 1999; 24: 179-185.
64. Mauk MD, Donegan NH. A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learn Memory 1997; 4: 130-158.
65. Svensson P, Ivarsson M, Hesslow G. Effect of varying the intensity and train frequency of forelimb and cerebellar mossy fiber conditioned stimuli on the latency of conditioned eye-blink responses in decerebrate ferrets. Learn Memory 1997; 4: 105-115.
66. Dow RS, Moruzzi G The Physiology and Pathology of the Cerebellum. Minneapolis: University of Minnesota Press, 1958.