Pharmacokinetics of lower doses of saquinavir soft-gel caps (800 and 1200 mg twice daily) boosted with itraconazole in HIV-1-positive patients

Antiviral Therapy

Volumn 8, Issue 3, 2003, Pages 245-249

  Cardiello, Peter G ^a   Samor, Tarika ^d   Burger, David ^b   Hoetelmans, Richard ^c   Mahanontharit, Apicha ^d   Ruxrungtham, Kiat ^d   Lange, Joep M ^a   Cooper, David A ^d   Phanuphak, Praphan ^d  

^a IATEC   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ITRACONAZOLE; SAQUINAVIR;

ADULT; AREA UNDER THE CURVE; ARTICLE; CALCULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CAPSULE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

ADULT; AREA UNDER CURVE; CAPSULES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HUMANS; ITRACONAZOLE; MALE; SAQUINAVIR;

EID: 0042154490     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Carpenter CC, Cooper DA, Fischl MA, Gatell JM, Gazzard BG, Hammer SM, Hirsch MS, Jacobsen DM, Katzenstein DA, Montaner JS, Richman DD, Saag MS, Schechter M, Schooley RT, Thompson MA, Vella S, Yeni PG & Volberding PA. Antiretroviral therapy in adults. Updated recommendations of the International AIDS Society - USA Panel. Journal of the American Medical Association 2000; 283:381-390.
2. Cardiello P, Kroon E, Hoetelmans R, Vorarien W, Ubolyam S, Phanupak P, Lange J, Cooper D & Ruxrungtham K. Steady-state pharmacokinetics (PK) of saquinavir (SQV) with and without two doses of itraconazole in HIV-1+ Thai patients: HIV NAT 001.2 substudy. XIII International AIDS Conference, Durban, South Africa, July 9-14, 2000 [abstract WeOrB545].
3. Hoetelmans RMW, van Heeswijk RPG, Meenhorst PL, Mulder JW, Scheele P & Beijnen JH. Plasma concentrations of saquinavir determine HIV-1 RNA response over a 48-week period. XII International AIDS Conference, Geneva, Switzerland, June-July, 1998 [abstract 42261].
4. Koks CH, van Heeswijk RP, Veldkamp AI, Meenhorst PL, Mulder JW, van der Meer JT, Beijnen JH & Hoetelmans RM. Itraconazole as an alternative for ritonavir liquid formulation when combined with saquinavir. AIDS 2000; 14(1):89-90.
5. Hoetelmans RM, Meenhorst PL, Mulder JW, Burger DM, Koks CH & Beijnen JH. Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir. Pharmacy World & Science 1997; 19(4):159-175.
6. Miyama T, Takanaga H, Matsuo H, Yamano K, Yamamoto K, Iga T, Naito M, Tsuruo T, Ishizuka H, Kawahara Y & Sawada Y. P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier. Antimicrobial Agents & Chemotherapy 1998; 42(7):1738-1744.
7. Veldkamp AI, van Heeswijk RP, Mulder JW, Chuenyam M, Ubolyam S, Newell ME, van Leeuwen R, Kunanusont C, Buranapraditkul S, Sirivichayakul S, Lange JM & Cooper DA. Steady-state pharmacokinetics of twice-daily dosing of saquinavir plus ritonavir in HIV-1-infected individuals. Journal of AIDS 2001; 27(4):344-349.
8. Kroon ED, Ungsedhapand C, Ruxrungtham K, Chuenyam M.; Ubolyam S, Newell ME, van Leeuwen R, Kunanusont C, Buranapraditkul S, Sirivichayakul S, Lange JM & Cooper DA. A randomized, double blind trial of half versus standard dose of zidovudine plus zalcitabine in Thai HIV-1-infected patients (study HIV-NAT 001). AIDS 2000; 14:1349-1356.
9. Hugen PW, Verweij-van Wissen CP, Burger DM, Wuis EW, Koopmans PP & Hekster YA. Simultaneous determination of the HIV-protease inhibitors indinavir, nelfinavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical Sciences & Applications 1999; 727(1-2):139-149.
10. Martindale. The Extra Pharmacopoiea. 28th Edition. Edited by Reynolds JEF. The Pharmaceutical Press, London, 1982.
11. Cardiello P, van Heeswijk R, Hassink E, Srasuebkul P, Mahanontharit A, Samor TM, Worarien W, Beijnen JH, Hoetelmans RM, Ruxrungtham K, Cooper DA, Lange JM & Phanuphak P. Simplifying protease inhibitor therapy with once daily dosing of saquinavir (soft gel)/ritonavir 1,600/100 mg: HIVNAT 001.3. Journal of AIDS 2002; 29(5):464-470.