Receptor activator of NF-κB ligand arrests bone growth and promotes cortical bone resorption in growing rats

Journal of Applied Physiology

Volumn 95, Issue 2, 2003, Pages 672-676

  McHugh, Nansie A ^a   Vercesi, Haydee M ^a   Egan, Robert W ^a   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Computed tomography; In vivo; Juvenile; Osteopenia; Receptor activator of nuclear factor B ligand

Indexed keywords

DEOXYPYRIDINOLINE; OSTEOCLAST DIFFERENTIATION FACTOR;

ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE GROWTH; BONE MINERAL; BONE REMODELING; BONE TURNOVER; CONTROLLED STUDY; CORTICAL BONE; CROSS LINKING; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; RAT; TRABECULAR BONE;

EID: 0042128757     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00056.2003     Document Type: Article

References (24)

1. Bonjour JP, Theintz G, Law F, Slosman D, and Rizzoli R. Peak bone mass. Osteoporosis Int 4, Suppl 1: 7-13, 1994.
2. Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, and Simonet WS. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12: 1260-1268, 1998.
3. Cao J, Venton L, Sakata T, and Halloran BP. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. J Bone Miner Res 18: 270-277, 2003.
4. Chambers TJ. Regulation of the differentiation and function of osteoclasts. J Pathol 192: 4-13, 2000.
5. Crabtree N, Loveridge N, Parker M, Rushton N, Power J, Bell KL, Beck TJ, and Reeve J. Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res 16: 1318-1328, 2001.
6. Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, and Schuh J. RANK is essential for osteoclast and lymph node development. Genes Dev 13: 2412-2424, 1999.
7. Fuller K, Wong B, Choi Y, and Chambers TJ. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 188: 997-1001, 1998.
8. 2 induced expression of receptor activator of nuclear factor-κB ligand/osteoprotegerin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency. J Bone Miner Res 15: 1321-1329, 2000.
9. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, and Boyle WJ. Osteoprotegrin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165-176, 1998.
10. Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, and Boyle WJ. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 97: 1566-1571, 2000.
11. Ma YL, Cain RL, Halladay DL, Yang X, Zeng Q, Miles RR, Chandrasedhar S, Martin TJ, and Onyia JE. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142: 4047-4054, 2001.
12. Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21: 115-137, 2000.
13. McCalden R, McGeough J, Barker M, and Court-Brown C. Age-related changes in the tensile properties of cortical bone: the relative importance of changes in porosity, mineralization and microstructure. J Bone Joint Surg Am 75: 1193-1205, 1993.
14. McHugh NA, Vercesi HM, Egan RW, and Hey JA. In vivo rat assay: bone remodeling and steroid effects on juvenile bone by pQCT quantification in 7 days. Am J Physiol Endocrinol Metab 284: E70-E75, 2003. First published September 3, 2002, 10.1152/ajpendo.00102.2002.
15. Quinn JMW, Elliot J, Gillespie MT, and Martin TJ. A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 139: 4424-4427, 1998.
16. Schenk R, Eggli P, Fleisch H, and Rosini S. Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat. Calcif Tissue Int 38: 342-349, 1986.
17. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, and Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357, 1999.
18. Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, Wagner EF, and Taniguchi T. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416: 744-749, 2002.
19. Turner CH and Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone 14: 595-608, 1993.
20. Turner RT, Bolander ME, Sarkar G, An KN, Maran A, and Ritman EL. An integrated approach to assess structure-to-function relationships in the skeleton. J Musculoskel Neuron Interact 2: 3-8, 2001.
21. Van Pottelbergh I, Goemaere S, Zmierczak H, De Bacquer D, and Kaufman JM. Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study. J Bone Miner Res 18: 303-311, 2003.
22. Warming L, Hassager C, and Christiansen C. Changes in bone mineral density with age in men and women: a longitudinal study. Osteoporos Int 13: 105-112, 2002.
23. Wasnich RD. Epidemiology of osteroporosis. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, edited by Kleerekoper M and Khosla S. Philadelphia, PA: Lippincott, Williams & Wilkins, 1999, p. 30-31, 257.
24. Winner S, Morgan C, and Grimley-Evans J. Perimenopausal risk of falling and incidence of distal forearm fracture. BMJ 298: 1486-1488, 1989.