N-acetylcysteine improves the disturbed thiol redox balance after methionine loading

Clinical Science

Volumn 105, Issue 2, 2003, Pages 173-180

  Raijmakers, Maarten T M ^a,c   Schilders, Geurt W ^a   Roes, Eva Maria ^a   Van Tits, Lambertus J H ^a   Hak Lemmers, Heidy L M ^a   Steegers, Eric A P ^b   Peters, Wilbert H M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Antioxidant; Endothelium; Free radical; Homocysteine; Redox balance

Indexed keywords

ACETYLCYSTEINE; CARBONYL DERIVATIVE; CYSTEINE; FIBRONECTIN; HOMOCYSTEINE; METHIONINE; REACTIVE OXYGEN METABOLITE; THIOL;

ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETYLCYSTEINE; ADULT; ANTIOXIDANTS; CROSS-OVER STUDIES; CYSTEINE; FEMALE; HOMOCYSTEINE; HUMANS; LIPID PEROXIDATION; MALE; METHIONINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS;

EID: 0042090586     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20030052     Document Type: Article

References (31)

1. Stamler, J. S. and Slivka, A. (1996) Biological chemistry of thiols in the vasculature and in vascular-related disease. Nutr. Rev. 54, 1-30
2. Fortin, L.-J. and Genest, Jr, J. (1995) Measurement of homocyst(e)ine in the prediction of arteriosclerosis. Clin. Biochem. 28, 155-162
3. Finkelstein, J. D. (1998) The metabolism of homocysteine: pathways and regulation. Eur. J. Pediatr. 157, S40-S44
4. Garciá de la Asunción, J., Del Olmo, M. L., Sastre, J. et al. (1998) AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. J. Clin. Invest. 102, 4-9
5. Meister, A. (1998) Glutathione metabolism and its selective modification. J. Biol. Chem. 263, 17205-17208
6. Hayes, J. D. and McLellan, L. I. (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radical Res. 31, 273-300
7. Sies, H. (1986) Biochemistry of oxidative stress. Angew. Chem. Int. Ed. Engl. 25, 1058-1071
8. Adams, S., Green, P., Claxton, R. et al. (2001) Reactive carbonyl formation by oxidative and non-oxidative pathways. Front. Biosci. 6, A17-A24
9. Raijmakers, M. T. M., Zusterzeel, P. L. M., Roes, E. M., Steegers, E. A. P., Mulder, T. P. J. and Peters, W. H. M. (2001) Oxidized and total whole blood thiols in women with preeclampsia. Obstet. Gynecol. 97, 272-276
10. Burgunder, J. M., Varriale, A. and Lauterburg, B. H. (1989) Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur. J. Clin. Pharmacol. 36, 127-131
11. Behr, J., Maier, K., Degenkolb, B., Krombach, F. and Vogelmeier, C. L. (1997) Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Am. J. Respir. Crit. Care Med. 156, 1897-1901
12. Ventura, P., Panini, R., Verlato, C., Scarpetta, G. and Salvioli, G. (2000) Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinemia induced by methionine oral loading. Metab. Clin. Exp. 49, 225-228
13. Kanani, P. M., Sinkey, C. A., Browning, R. L., Allaman, M., Knapp, H. R. and Haynes, W. G. (1999) Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 100, 1161-1168
14. Powers, R. W., Majors, A. K., Schmidt, B. P. and Roberts, J. M. (2000) Evidence of endothelial dysfunction in response to increased homocyst(e)ine: possible mediator of injury in preeclampsia? Hypertens. Pregnancy 19, 93
15. Chambers, J. C., McGregor, A., Jean-Marie, J., Obeid, O. A. and Kooner, J. S. (1999) Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 99, 1156-1160
16. Raijmakers, M. T. M., Zusterzeel, P. L. M., Steegers, E. A. P., Hectors, M. P. C., Demacker, P. N. M. and Peters, W. H. M. (2000) Plasma thiol status in preeclampsia. Obstet. Gynecol. 95, 180-184
17. Benzie, I. F. and Strain, J. J. (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal. Biochem. 239, 70-76
18. Buss, H., Chan, T. P., Sluis, K. B., Domigan, N. M. and Winterbourn, C. C. (1997) Protein carbonyl measurement by a sensitive ELISA method. Free Radical Biol. Med. 23, 361-366
19. Schultze, A. E., Emeis, J. J. and Roth, R. A. (1996) Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole. Biochem. Pharmacol. 51, 187-191
20. Conti, M., Morand, P. C., Levillain, P. and Lemonnier, A. (1991) Improved fluorometric determination of malonaldehyde. Clin. Chem. 37, 1273-1275
21. Chao, C. L., Kuo, T. L. and Lee, Y. T. (2000) Effects of methionine-induced hyperhomocysteiaemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation 101, 485-490
22. Ueland, P. M., Mansoor, M. A., Guttormsen, A. B. et al. (1996) Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status: a possible element of the extracellular antioxidant defense system. J. Nutr. 126, 1281S-1284S
23. Ventura, P., Panini, R., Pasini, M. C., Szarpetta, G. and Salvioli, G. (1999) N-Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol. Res. 40, 345-350
24. Wiklund, O., Fager, G., Andersson, A., Lundstam, U., Masson, P. and Hultberg, B. (1996) N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis 119, 99-106
25. Mansoor, M. A., Svardal, A. M., Schneede, J. and Ueland, P. M. (1992) Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men. Clin. Chem. 38, 1316-1321
26. Loscalzo, J. (1996) The oxidant stress of hyperhomocyst(e)inemia. J. Clin. Invest. 98, 5-7
27. Hogg, N. (1999) The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radical Biol. Med. 27, 28-33
28. Zusterzeel, P. L. M., Rutten, H., Roelofs, H. M. J., Peters, W. H. M. and Steegers, E. A. P. (2001) Protein carbonyls in decidua and placenta of pre-eclamptic women as markers for oxidative stress. Placenta 22, 213-219
29. Shibata, E., Ejima, K., Nanri, H. et al. (2001) Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects. Placenta 22, 566-572
30. Gredmark, T., Bergman, B. and Hellström, L. (1999) Total fibronectin in maternal plasma as a predictor for preeclampsia. Gynecol. Obstet. Invest 47, 89-94
31. Powers, R. W., Evans, R. W., Majors, A. K. et al. (1998) Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am. J. Obstet. Gynecol. 179, 1605-1611