The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation

Biochemistry

Volumn 42, Issue 31, 2003, Pages 9482-9490

  Dong, Jian ^a   Lu, Xuefeng ^b   Wei, Yansheng ^b   Luo, Lusong ^b   Dunaway Mariano, Debra ^b   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; HYDROGEN BONDS; HYDROLYSIS; RAMAN SPECTROSCOPY;

CHLORIDE ION EXPULSION;

COENZYMES;

4 CHLOROBENZOYL COENZYME A; 4 CHLOROBENZOYL COENZYME A DEHALOGENASE; 4 HYDROXYBENZOYL COENZYME A; 4 METHYLBENZOYL COENZYME A; ACYL SERINE PROTEINASE; ASPARTIC ACID; CARBONYL DERIVATIVE; CHLORIDE ION; CHLOROBENZENE; COENZYME A; DEHALOGENASE H; ENZYME; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL REACTION INTERMEDIATE; CHEMICAL REACTION KINETICS; DEHALOGENATION; ELIMINATION REACTION; ENERGY TRANSFER; ENTHALPY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MEISENHEIMER COMPLEX; MOLECULAR MODEL; MUTATION; POLARIZATION; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RAMAN SPECTROMETRY;

BINDING SITES; CATALYSIS; CHLOROBENZOATES; ESCHERICHIA COLI; HYDROGEN BONDING; HYDROLASES; HYDROLYSIS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTRUM ANALYSIS, RAMAN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

ERETMOCHELYS IMBRICATA; KOBUS;

EID: 0042071614     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0347656     Document Type: Article

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