Electric fields in active sites: Substrate switching from null to strong fields in thiol- and selenol-subtilisins

Biochemistry

Volumn 38, Issue 20, 1999, Pages 6659-6667

  Dinakarpandian, Deendayal ^a   Shenoy, Bhami C ^a   Hilvert, Donald ^b   McRee, Duncan E ^c   McTigue, Michele ^c   Carey, Paul R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ETH ZURICH   (Switzerland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; SELENIUM DERIVATIVE; SUBTILISIN; THIOL DERIVATIVE; THIOPHENE DERIVATIVE;

ALPHA HELIX; ARTICLE; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; DEACYLATION; ELECTRIC FIELD; ELECTROCHEMISTRY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACYLATION; ALANINE; AMINO ACID SUBSTITUTION; ASPARAGINE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ELECTROSTATICS; ESTERS; GLYCINE; KINETICS; MODELS, MOLECULAR; PROLINE; PROTEIN CONFORMATION; SELENOCYSTEINE; SPECTRUM ANALYSIS, RAMAN; SUBSTRATE SPECIFICITY; SUBTILISINS;

EID: 0033580651     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9902541     Document Type: Article

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