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Volumn 19, Issue 16, 2003, Pages 6456-6464

Detection of single nucleotide mismatches via fluorescent polymer superquenching

Author keywords

[No Author keywords available]

Indexed keywords

COATING TECHNIQUES; DNA; FLUORESCENCE; QUENCHING; SENSORS;

EID: 0042069981     PISSN: 07437463     EISSN: None     Source Type: Journal    
DOI: 10.1021/la034323v     Document Type: Article
Times cited : (82)

References (38)
  • 28
    • 0002586862 scopus 로고    scopus 로고
    • Nielsen, P. E., Egholm, M., Eds.; Horizon Scientific Press: Norfolk, U.K.
    • Koch, T. In Peptide Nucleic Acids; Nielsen, P. E., Egholm, M., Eds.; Horizon Scientific Press: Norfolk, U.K., 1999; pp 21-37.
    • (1999) Peptide Nucleic Acids , pp. 21-37
    • Koch, T.1
  • 32
    • 0041604069 scopus 로고    scopus 로고
    • note
    • Preliminary results using a variety of microspheres bearing different overall surface charges have indicated that the nonspecific interactions of DNA-QTL increases with increasing positive charge and are essentially absent in the presence of negatively charged microspheres. Furthermore, the nonspecific response generated by a microsphere surface is dominated by the charge of the polymer that is coated onto the microsphere surface. For example, all the spheres that we have coated with a positively charged polymer exhibit strong nonspecific binding with DNA regardless of the overall charge of the microsphere/polymer complex.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.