The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 29463-29470

  Bos, Ineke G A ^a,d   Lubbers, Yvonne T P ^a   Roem, Dorina ^a   Abrahams, Jan Pieter ^b   Hack, C Erik ^a,c   Eldering, Eric ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d SANQUIN RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; ENZYME INHIBITION; GENES; GENETIC ENGINEERING; REACTION KINETICS;

MUTATIONS;

BIOCHEMISTRY;

ANTITHROMBIN III; COMPLEMENT COMPONENT C1S INHIBITOR; HEPARIN; MUTANT PROTEIN; SERINE PROTEINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ANGIONEUROTIC EDEMA; ARTICLE; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITOR INTERACTION; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, WESTERN; CENTRIFUGATION, DENSITY GRADIENT; COMPLEMENT C1 INACTIVATOR PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXONS; GENE DELETION; GLYCINE; HEAT; HEPARIN; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PLASMIDS; POLYMERASE CHAIN REACTION; PROLINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE; SERPINS; SUCROSE; TEMPERATURE;

EID: 0042031178     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302977200     Document Type: Article

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