Cytokine production of RSV/PHA-stimulated tonsillar mononuclear cells: Influences of age and atopy

European Respiratory Journal

Volumn 22, Issue 2, 2003, Pages 317-322

  Ichinohe, S ^a,b,c   Hussain, I R ^a   Johnston, S L ^a,b  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c Chiba Prefec Inst of Public Health   (Japan)

Author keywords

Allergic sensitisation; Respiratory syncytial virus; T helper cell type 1; T helper cell type 2

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; PHYTOHEMAGGLUTININ; RANTES;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; ATOPY; BRONCHIOLITIS; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNE RESPONSE; MALE; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; T LYMPHOCYTE ACTIVATION; TARGET ORGAN; TONSIL CELL; VIRUS REPLICATION;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LEUKOCYTES, MONONUCLEAR; MALE; PHYTOHEMAGGLUTININS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; TONSIL;

EID: 0042026696     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00087902     Document Type: Article

References (24)

1. National Institute of Health, National Heart, Lung, and Blood Institute (NHLBI)/World Health Organisation. Epidemiology. In: Global Initiative for Asthma - global strategy for asthma management and prevention. Bethesda, MD, USA, NHLBI, 1995; pp. 9-24.
2. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. N Engl J Med 1995; 332: 133-138.
3. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000; 161: 1501-1507.
4. Delves PJ, Roitt IM. The immune system, second of two parts. N Eng J Med 2000; 343: 108-117.
5. Kelso A. Th1 and Th2 subsets: paradigms lost? Immunol Today 1995; 16: 374-379.
6. Robinson DS, Hamid Q, Ying S, et al. Predominant TH2-like T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
7. Johnston SL, Openshaw PJM. The protective effect of childhood infections. BMJ 2001; 322: 376-377.
8. Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 2002; 359: 831-834.
9. van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC II, Welliver RC. Increased production of IFN-γ and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol 1999; 103: 630-636.
10. Aberle JH, Aberle SW, Dworzak MN, et al. Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am J Respir Crit Care Med 1999; 160: 1263-1268.
11. Renzi PM, Turgeon JP, Marcotte JE, et al. Reduced interferon-γ production in infants with bronchiolitis and asthma. Am J Respir Crit Care Med 1999; 159: 1417-1422.
12. Bont L, Heijnen CJ, Kavelaars A, et al. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur Respir J 1999; 14: 144-149.
13. Bont L, Kavelaars A, Heijnen CJ, van Vught AJ, Kimpen JL. Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis. J Infect Dis 2000; 181: 1772-1775.
14. Noah TL, Becker S. Respiratory syncytial virus-induced cytokine production by a human bronchial epithelial cell line. Am J Physiol 1993; 265: 472-478.
15. Becker S, Reed W, Henderson FW, Noah TL. RSV infection of human airway epithelial cells causes production of the beta-chemokine RANTES. Am J Physiol 1997; 272: 512-520.
16. Roman M, Calhoun WJ, Hinton KL, et al. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 1997; 156: 190-195.
17. Thurau AM, Streckert HJ, Rieger CH, Schauer U. Increased number of T cells committed to IL-5 production after respiratory syncytial virus (RSV) infection of human mononuclear cells in vitro. Clin Exp Immunol 1998; 113: 450-455.
18. Diaz PV, Calhoun WJ, Hinton KL, et al. Differential effects of Respiratory Syncytial Virus and Adenovirus on mononuclear cell cytokine responses. Am J Respir Crit Care Med 1999; 160: 1157-1164.
19. Anderson LJ, Tsou C, Potter C, et al. Cytokine response to respiratory syncytial virus stimulation of human peripheral blood mononuclear cells. J Infect Dis 1994; 170: 1201-1208.
20. Brandenburg AH, Kleinjan A, van Het Land B, et al. Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol 2000; 62: 267-277.
21. Wakasugi N, Virelizier JL. Defective IFN-γ production in the human neonate. I Dysregulation rather than intrinsitic abnormality. J Immunol 1985; 134: 167-171.
22. Lewis DB, Yu CC, Meyer J, English BK, Kahn SJ, Wilson CB. Cellular and molecular mechanisms for reduced interleukin-4 and interferon-γ production by neonatal T-cells. J Clin Invest 1991; 87: 194-202.
23. Elsasser-Beile U, Dursunoglu B, Gallati H, Monting JS, von Kleist S. Comparison of cytokine production in blood cell cultures of healthy children and adults. Pediatr Allergy Immunol 1995; 6: 170-174.
24. Lilic D, Cant AJ, Abinun M, Calvert JE, Spickett G. Cytokine production differs in children and adults. Pediatr Research 1997; 42: 237-241.