Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity

Development

Volumn 130, Issue 16, 2003, Pages 3757-3766

  Goodman, S Jay ^a   Branda, Catherine S ^a,b   Robinson, Matthew K ^a,c   Burdine, Rebecca D ^a,d   Stern, Michael J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

Achondroplasia; Alternative splicing; Chemoattraction; EGL 15; FGF receptor; Sex myoblast

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; ISOPROTEIN; LIGAND;

ALLELE; ALTERNATIVE RNA SPLICING; ARTICLE; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE LOCUS; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHEMOTAXIS; LIGANDS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSGENES;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 0042009406     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00604     Document Type: Article

References (36)

1. Boilly, B., Vercoutter-Edouart, A. S., Hondermarck, H., Nurcombe, V. and Le Bourhis, X. (2000). FGF signals for cell proliferation and migration through different pathways. Cytokine Growth Factor Rev. 11, 295-302.
2. Borland, C. Z., Schutzman, J. L. and Stern, M. J. (2001). Fibroblast growth factor signaling in Caenorhabditis elegans. BioEssays 23, 1120-1130.
3. Branda, C. S. and Stern, M. J. (2000). Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Dev. Biol. 226, 137-151.
4. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
5. Burdine, R. D., Chen, E. B., Kwok, S. F. and Stern, M. J. (1997). egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 94, 2433-2437.
6. Burdine, R. D., Branda, C. S. and Stern, M. J. (1998). EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans. Development 125, 1083-1093.
7. Chang, Z., Meyer, K., Rapraeger, A. C. and Friedl, A. (2000). Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ. FASEB J. 14, 137-144.
8. Chen, E. B. and Stern, M. J. (1998). Understanding cell migration guidance: lessons from sex myoblast migration in C. elegans. Trends Genet. 14, 322-327.
9. DeVore, D. L., Horvitz, H. R. and Stern, M. J. (1995). An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83, 611-620.
10. Dionne, C. A., Jaye, M. and Schlessinger, J. (1991). Structural diversity and binding of FGF receptors. Science 638, 161-166.
11. Freeman, M. (1998). Complexity of EGF receptor signalling revealed in Drosophila. Curr. Opin. Genet. Dev. 8, 407-411.
12. Green, P. J., Walsh, F. S. and Doherty, P. (1996). Promiscuity of fibroblast growth factor receptors. BioEssays 18, 639-646.
13. Hanks, S. K. and Quinn, A. M. (1991). Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200, 38-81.
14. Herman, R. K. (1988). Genetics. In The Nematode Caenorhabditis elegans (ed. W. B. Wood), pp. 17-45. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
15. Kim, I., Moon, S., Yu, K., Kim, U. and Koh, G. Y. (2001). A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). Biochim. Biophys. Acta 1518, 152-156.
16. Klint, P. and Claesson-Welsh, L. (1999). Signal transduction by fibroblast growth factor receptors. Front. Biosci. 4, D165-D177.
17. Kokel, M., Borland, C. Z., DeLong, L., Horvitz, H. R. and Stern, M. J. (1998). clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12, 1425-1437.
18. Landgren, E., Klint, P., Yokote, K. and Claesson-Welsh, L. (1998). Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding. Oncogene 17, 283-291.
19. McKeehan, W. L., Wang, F. and Kan, M. (1998). The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Prog. Nucleic Acid Res. Mol. Biol. 59, 135-176.
20. Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
21. Mohammadi, M., Schlessinger, J. and Hubbard, S. R. (1996). Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 86, 577-587.
22. Moore, D. S. and McCabe, G. P. (1993). Introduction to the Practice of Statistics. New York: W. H. Freeman and Company.
23. Ornitz, D. M. (2000). FGFs, heparan sulfate and FGFRs: complex interactions essential for development. BioEssays 22, 108-112.
24. Ornitz, D. M. and Itoh, N. (2001). Fibroblast growth factors. Genome Biol. 2, reviews3005.1-3005.12.
25. Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G. and Goldfarb, M. (1996). Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271, 15292-15297.
26. Perrimon, N. and Bernfield, M. (2000). Specificities of heparan sulphate proteoglycans in developmental processes. Nature 404, 725-728.
27. Prinos, P., Kilpatrick, M. W. and Tsipouras, P. (1995). A novel G346E FGFR3 mutations in achondroplasia. Pediatr. Res. Suppl. 37, 151A.
28. Roubin, R., Vatcher, G., Popovici, C., Coulier, F., Thierry-Mieg, J., Pontarotti, P., Birnbaum, D., Baillie, D. and Thierry-Mieg, D. (1999). let-756, a C. elegans fgf essential for worm development. Oncogene 18, 6741-6747.
29. Schutzman, J. L., Borland, C. Z., Newman, J. C., Robinson, M. K., Kokel, M. and Stern, M. J. (2001). The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Mol. Cell. Biol. 21, 8104-8116.
30. Schweitzer, R. and Shilo, B. Z. (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13, 191-196.
31. Shimizu, A., Tada, K., Shukunami, C., Hiraki, Y., Kurokawa, T., Magane, N. and Kurokawa-Seo, M. (2001). A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. J. Biol. Chem. 276, 11031-11040.
32. Stern, M. J. and Horvitz, H. R. (1991). A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Development 113, 797-803.
33. Sulston, J. E. and Horvitz, H. R. (1977). Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol. 56, 110-156.
34. Thomas, J. H., Stern, M. J. and Horvitz, H. R. (1990). Cell interactions coordinate the development of the C. elegans egg-laying system. Cell 62, 1041-1052.
35. Wang, F., Kan, M., Yan, G., Xu, J. and McKeehan, W. L. (1995). Alternately spliced NH2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. J. Biol. Chem. 270, 10231-10235.
36. Webster, M. K. and Donoghue, D. J. (1997). FGFR activation in skeletal disorders: too much of a good thing. Trends Genet. 13, 178-182.