Safety-catch linker strategies for the production of radiopharmaceuticals labeled with positron-emitting isotopes

Journal of the American Chemical Society

Volumn 125, Issue 34, 2003, Pages 10168-10169

  Maclean, Derek ^a   Zhu, Jiang ^a   Chen, Mingying ^a   Hale, Ron ^a,c   Satymurthy, Nagichettiar ^b   Barriot, Jorge R ^b  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALEXZA Molecular Delivery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADIOPHARMACEUTICAL AGENT;

ALKYLATION; ANALYTIC METHOD; ARTICLE; COMBINATORIAL CHEMISTRY; CONTRAST ENHANCEMENT; DRUG ISOLATION; DRUG SCREENING; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; TECHNIQUE;

ALKYLATION; CROSS-LINKING REAGENTS; HYDROCARBONS, IODINATED; ISOTOPE LABELING; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0041931990     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034725p     Document Type: Article

References (28)

1. Phelps, M. E. J. Nucl. Med. 2000, 41, 661-681.
2. (a) Farde, L. Trends Neurosci. 1996, 19, 211-214.
3. (b) Pike, V. W. Drug Inf. J. 1997, 31,997-1013.
4. (c) Burns, H. D.; Hamill, T. G.; Eng, W.; Francis, B.; Fioravanti, C.; Gibson, R. E. Curr. Opin. Chem. Biol. 1999, 3, 388-394.
5. Cherry, S. R. J. Clin. Pharmacol. 2001, 41, 482-491.
6. 18F (110 min).
7. (a) Fowler, J. S.; Wolf, A. P. Acc. Chem. Res. 1997, 30, 181-188.
8. (b) Långström, B.; Kihlberg, T.; Bergström, M.; Antoni, G.; Björkman, M.; Forngren, B.H.; Rorngren, T.; Hartvig, P.; Markides, K.; Yngve, U.; Ogren, M. Acta Chem. Scand. 1999, 53, 651-669.
9. (a) Kenner, G. W.; McDermott, J. R,; Sheppard, R. C. Chem. Commun. 1971, 636-637.
10. (b) Backes, B. J; Ellman, J. A. Curr. Opin. Chem. Biol. 1997, 1, 86-93.
11. Bolton, R. J. Labelled Compd, Radiopharm. 2001, 44, 701-736.
12. (a) Morphy, J. R.; Rankovic, Z.; Rees, D. C. Tetrahedron Lett. 1996, 37, 3209-3212.
13. (b) Brown, A. R.; Rees, D. C.; Rankovic, Z.; Morphy, J. R. J. Am. Chem. Soc. 1997, 119, 3288-3295.
14. (a) Heinonen, P.; Lönnberg, H Tetrahedron Lett. 1997, 49, 8569-8572.
15. (b) Kroll, F. E. K.; Morphy, J. R.; Rees, D. C.; Gani, D. Tetrahedron Lett. 1997, 38, 8573-8576.
16. (c) Blaney, P.; Grigg, R.; Rankovic, Z.; Thoroughgood, M. Tetrahedron Lett. 2000, 41, 6635-6638.
17. (d) Tumelty, D.; Cao, K.; Holmes, C. P. Org. Lett. 2001.3, 83-86.
18. (e) Cai, J.; Wathey, B. Tetrahedron Lett. 2001, 42, 1383-1385.
19. (a) Backes, B. J.; Ellman, J. A. J. Am. Chem. Soc. 1994, 116, 11171-11172.
20. (b) Backes, B. J.; Virgilio, A. A.; Ellman, J. A. J. Am. Chem. Soc. 1996, 118, 3055-3056.
21. (c) Backes. B. J.; Ellman, J. A. J. Org. Chem. 1999, 64, 2322-2330.
22. (d) Backes, B. J.; Dragoli, D. R.; Ellman, J. A. J. Org. Chem. 1999, 64, 5472-5478.
23. (e) Golisade, A.; Herforth, C.; Wieking, K.; Kunick, C.; Link, A. Bioorg. Med. Chem. Lett. 2001, 11, 1783-1786.
24. Maclean, D.; Hale, R.; Chen, M. Org. Lett. 2001, 3, 2977-2980.
25. Ouyang X.; Armstrong, R. W.; Murphy, M. M. J. Org. Chem. 1998, 63, 1027-1032.
26. Halldin, C.; Farde, L.; Hogberg, T.; Hall, H.; Sedvall, G. Appl. Radiat. Isot, 1990, 41, 669-674.
27. Chatziioannou, A. F. Mol. Imaging Biol. 2002, 4, 47-63.
28. Moon, H. S.; Jacobson, E. M.; Khersonsky, S. M.; Luzung, M. R.; Wals, D. P.; Xong, W.; Lee, J. W.; Parikh, P. B.; Lam, J. C.; Kang, T. W.; Rosania, G. R.; Schier, A, F.; Chang, Y. T. J. Am. Chem. Soc. 2002, 124, 11608-11609 and references therein.