Constitutively active PKB/Akt inhibited apoptosis and down-regulated β1,4-galactosyltransferase 1 in hepatocarcinoma cells

Biochemical and Biophysical Research Communications

Volumn 309, Issue 2, 2003, Pages 279-285

  Zhu, Xiaoyu ^a   Chen, She ^a   Yin, Xianglei ^a   Shen, Aiguo ^a   Ji, Shuying ^a   Shen, Zonghou ^a   Gu, Jianxin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Protein kinase B; 1,4 Galactosyltransferase1

Indexed keywords

BETA1,4 GALACTOSYLTRANSFERASE 1; CYCLOHEXIMIDE; GAG PROTEIN; GALACTOSYLTRANSFERASE; MESSENGER RNA; PROTEIN KINASE B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROMOTER REGION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0041923889     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.04.001     Document Type: Article

References (32)

1. Shur B.D. Cell surface beta 1,4 galactosyltransferase: twenty years later. Glycobiology. 6:1991;563-575.
2. Shur B.D. Glycosyltransferases as cell adhesion molecules. Curr. Opin. Cell Biol. 5:1993;854-863.
3. Youakim A., Dubois D.H., Shur B.D. Localization of the long form of beta-1,4-galactosyltransferase to to the plasma membrane and Golgi complex of 3T3 and F9 cells by immunofluorescence confocal microscopy. Proc. Natl. Acad. Sci. USA. 91:1994;10913-10917.
4. Furukawa K., Sato T. Beta-1,4-galactosylation of N-glycans is a complex process. Biochim. Biophys. Acta. 1473:1999;54-66.
5. Gong X., Dubois D.H., Miller D.J., Shur B.D. Activation of a G protein complex by aggregation of beta-1,4-galactosyltransferase on the surface of sperm. Science. 269:1995;1718-1721.
6. Maillet C.M., Shur B.D. Perturbing cell surface beta-(1,4)-galactosyltransferase on F9 embryonal carcinoma cells arrests cell growth and induces laminin synthesis. J. Cell Sci. 107:1994;1713-1724.
7. Hinton D.A., Evans S.C., Shur B.D. Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp. Cell Res. 219:1995;640-649.
8. Purushotham K.R., Dunn W.A., Schneyer C.A., Humphreys-Beher M.G. A novel mechanism for isoprenaline-stimulated proliferation of rat parotid acinar cells involving the epidermal growth factor receptor and cell surface galactosyltransferase. Biochem. J. 284:1992;767-776.
9. Appeddu P.A., Shur B.D. Molecular analysis of cell surface beta-1,4-galactosyltransferase function during cell migration. Proc. Natl. Acad. Sci. USA. 91:1994;2095-2099.
10. Harduin-Lepers A., Shaper J.H., Shaper N.L. Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene: evidence for a negative regulatory element that controls initiation at the proximal site. J. Biol. Chem. 268:1993;14348-14359.
11. Rajput B., Shaper N.L., Shaper J.H. Transcriptional regulation of murine beta1,4-galactosyltransferase in somatic cells. Analysis of a gene that serves both a housekeeping and a mammary gland-specific function. J. Biol. Chem. 271:1996;5131-5142.
12. Pasqualetto V., Lemaire S., Neel D., Aubery M., Berger E.G., Derappe C. Phorbol ester treatment of HL 60 leukemia cells results in increase of beta-(1. → 4)-galactosyltransferase Carbohydr. Res. 328:2000;301-305.
13. Zhang S.W., Fu X.Y., Cao S.L., Shen Z.H., Gu J.X. Down-regulation of beta1,4-galactosyltransferase gene expression by cell-cycle suppressor gene p16. Biochim. Biophys. Acta. 1444:1999;49-54.
14. Zhang S.W., Lin W.S., Ying X.L., Zhu D., Guo M.Y., Gu J.X. Effect of suppression of TGF-beta1 expression on cell-cycle and gene expression of beta-1,4-galactosyltransferase 1 in human hepatocarcinoma cells. Biochem. Biophys. Res. Commun. 273:2000;833-838.
15. Zhang S., Cai M.M., Zhang S.W., Hu Y., Gu J.X. Involvement of β1,4 galactosyltransferase 1 and Galβ1. → 4GlcNAc groups in human hepatocarcinoma cell apoptosis Mol. Cell. Biochem. 243:2003;81-86.
16. Brazil D.P., Hemmings B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26:2001;657-664.
17. Staal S.P. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. USA. 84:1987;5034-5037.
18. Coffer P.J., Jin J., Woodgett J.R. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335:1998;1-13.
19. Bellacosa A., Franke T.F., Gonzalez-Portal M.E., Datta K., Taguchi T., Gardner J., Cheng J.Q., Testa J.R., Tsichlis P.N. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 8:1993;745-754.
20. Aoki M., Batista O., Bellacosa A., Tsichlis P., Vogt P.K. The akt kinase: molecular determinants of oncogenicity. Proc. Natl. Acad. Sci. USA. 95:1998;14950-14955.
21. Mende I., Malstrom S., Tsichlis P.N., Vogt P.K., Aoki M. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene. 20:2001;4419-4423.
22. Hemmings B.A. Akt signaling: linking membrane events to life and death decisions. Science. 275:1997;628-630.
23. Kulik G., Klippel A., Weber M.J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1997;1595-1606.
24. Kulik G., Weber M.J. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol. Cell. Biol. 18:1998;6711-6718.
25. Brognard J., Clark A.S., Ni Y., Dennis P.A. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 61:2001;3986-3997.
26. Ng S.S.W., Tsao M.S., Chow S., Hedley D.W. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res. 60:2000;5451-5455.
27. Zhou D., Jiang S., Shen Z., Gu, J. Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase. Biochem. J. 320:1996;623-625.
28. Hsu S.M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem. 29:1981;577-580.
29. Fukuda M.N., Masri K.A., Dell A., Luzzatto L., Moremen K.W. Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II. Proc. Natl. Acad. Sci. USA. 87:1990;7443-7447.
30. Perillo N.L., Pace K.E., Seilhamer J.J., Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature. 378:1995;736-739.
31. Thara Y., Sakamoto Y., Mihara M., Shimizu K., Taniguchi N. Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor. J. Biol. Chem. 272:1997;9629-9634.
32. Nicholson K.M., Anderson N.G. The protein linase B/Akt signalling pathway in human malignancy. Cell. Signal. 14:2002;381-395.