Diadenosine-5-phosphate exerts A1-receptor-mediated proarrhythmic effects in rabbit atrial myocardium

British Journal of Pharmacology

Volumn 139, Issue 7, 2003, Pages 1265-1272

  Brandts, B ^a   Borchard, R ^a   Dirkmann, D ^a   Wickenbrock, I ^a   Sievers, B ^a   Van Bracht, M ^a   Prull, M W ^a   Trappe, H J ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

A 1 receptor; Adenosine; Atrial fibrillation; Atrial myocyte; Cardiac cell; Diadenosine polyphosphates; Electrophysiology; Muscarinic K + current

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; DIADENOSINE PENTAPHOSPHATE; DIPYRIDAMOLE;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART CYCLE; HEART MUSCLE; HEART PERFUSION; HEART STIMULATION; ISOLATED HEART; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; RECEPTOR INTRINSIC ACTIVITY; REFRACTORY PERIOD;

ACETYLCHOLINE; ADENOSINE; ANIMALS; ATRIAL FIBRILLATION; ATRIAL FUNCTION; DINUCLEOSIDE PHOSPHATES; DIPYRIDAMOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HEART ATRIA; HEART RATE; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PERFUSION; RABBITS; RECEPTOR, ADENOSINE A1; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SIGNAL TRANSDUCTION; XANTHINES;

EID: 0041887053     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705361     Document Type: Article

References (24)

1. + current in guinea-pig atrial myocytes by a serum factor. J. Physiol., 461, 263-281.
2. BELARDINELLI, L., SHRYOCK, J.C., SONG, Y., WANG, D. & SRINIVAS, M. (1995). Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J., 9, 359-365.
3. K(Ach) by diadenosine polyphosphates in guinea-pig atrial myocytes. J. Physiol., 512 (Part 2), 407-420.
4. CARRASCO, A.J., DZEJA, P.P., ALEKSEEV, A.E., PUCAR, D., ZINGMAN, L.V., ABRAHAM, M.R., HODGSON, D., BIENENGRAEBER, M., PUCEAT, M., JANSSEN, E., WIERINGA, B. & TERZIC, A. (2001). Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proc. Natl. Acad. Sci. U.S.A., 98, 7623-7628.
5. FLORES, N.A., STAVROU, B.M. & SHERIDAN, D.J. (1999). The effects of diadenosine polyphosphates on the cardiovascular system. Cardiovasc. Res., 42, 15-26.
6. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391, 85-100.
7. 2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br. J. Pharmacol., 118, 1294-1300.
8. γ. to the GIRK 1 G protein gated inwardly rectifying K channels is important for channel activation. Neuron, 15, 1133-1143.
9. + channel, a target for diadenosine 5′,5″-P1,P5-pentaphosphate. Naunyn-Schmiedebergs Arch. Pharmacol., 353, 241-244.
10. JOVANOVIC, A., JOVANOVIC, S., MAYS, D.C., LIPSKY, J.J. & TERZIC, A. (1998). Diadenosine 5′,5″-P1,P5-pentaphosphate harbors the properties of a signaling molecule in the heart. FEBS Lett., 27,423, 314-318.
11. ATP channels, operative state-dependent regulation by a nucleoside diphosphate. Pflugers Arch., 431, 800-802.
12. KABELL, G., BUCHANAN, L.V., GIBSON, J.K. & BELARDINELLI, L. (1994). Effects of adenosine on atrial refractoriness and arrhythmias. Cardiovasc. Res., 28, 1385-1389.
13. + channels in mammalian ventricular myocytes. Am. J. Physiol., 266 (Part 2), H1812-H1821.
14. KURACHI, Y. (1995). G protein regulation of cardiac muscarinic potassium channel. Am. J. Physiol., 269 (Part 1), C821-C830.
15. LUO, J., JANKOWSKI, J., KNOBLOCH, M., VAN DER GIET, M., GARDANIS, K., RUSS, T., VAHLENSIECK, U., NEUMANN, J., SCHMITZ, W., TEPEL, M., DENG, M.C., ZIDEK, W. & SCHLUTER, H. (1999). Identification and characterization of diadenosine 5′,5″-P1,P2-diphosphate and diadenosine 5′,5″-P1,P3-triphosphate in human myocardial tissue. FASEB J., 13, 695-705.
16. MATEO, J., NIRAS-POTUGAL, M.T. & ROTLLAN, P. (1997). Ectoenzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cell. Am. J. Physiol., 273, C918-C927.
17. NEUMANN, J., MEISSNER, A., BOKNIK, P., GOMBOSOVA, I., KNAPP, J., LUSS, H., MULLER, F.U., SCHLUTER, H., ZIDEK, W., ROLF, N., VAN AKEN, H., VAHLENSIECK, U. & SCHMITZ, W. (1999). Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations. J. Cardiovasc. Pharmacol., 33, 151-156.
18. NUNAIN, S.O., GARRATT, C., PAUL, V., DEBBAS, N., WARD, D.E. & CAMM, A.J. (1992). Effect of intravenous adenosine on human atrial and ventricular repolarisation. Cardiovasc. Res., 26, 939-943.
19. OGILVIE, A., BLASIUS, R., SCHULZE-LOHOFF, E. & STERZEL, R.B. (1996). Adenine dinucleotides, a novel class of signalling molecules. J. Auton. Pharmacol., 16, 325-328.
20. RUBINO, A. & BURNSTOCK, G. (1996). Possible role of diadenosine polyphosphates as modulators of cardiac sensory-motor neurotransmission in guinea-pigs. J. Physiol., 1495 (Part 2), 515-523.
21. SHEN, W.K. & KURACHI, Y. (1995). Mechanisms of adenosine-mediated actions on cellular and clinical cardiac electrophysiology. Mayo Clin. Proc., 70, 274-291.
22. STAVROU, B.M., BECK, C. & ELORES, N.A. (2001). Changes in extracellular pH and myocardial ischaemia alter the cardiac effects of diadenosine tetraphosphate and pentaphosphate. Br. J. Pharmacol., 134, 639-647.
23. 4A) in human and animal cardiac preparations. J. Pharmacol. Exp. Ther., 288, 805-813.
24. 1-adenosine receptors. Br. J. Pharmacol., 119, 835-844.