Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations

Journal of Cardiovascular Pharmacology

Volumn 33, Issue 1, 1999, Pages 151-156

  Neumann, J ^a   Meissner, A ^b   Boknik P ^a   Gombosova I ^a   Knapp, J ^a   Luss H ^a   Muller F U ^a   Schluter H ^c   Zidek, W ^c   Rolf, N ^b   Van Aken, H ^b   Vahlensieck, U ^a   Schmitz, W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Adenosine receptors; Diadenosine tetraphosphate; Inotropy

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE RECEPTOR; DIADENOSINE TETRAPHOSPHATE; ISOPRENALINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FORCE; HEART; HEART CONTRACTION; INOTROPISM; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ATRIAL FUNCTION; CARDIOTONIC AGENTS; DINUCLEOSIDE PHOSPHATES; DOGS; HEART VENTRICLES; ISOPROTERENOL; MYOCARDIAL CONTRACTION; PLATELET AGGREGATION INHIBITORS; RECEPTORS, PURINERGIC P1;

EID: 0032953629     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199901000-00023     Document Type: Article

References (31)

1. Schlüter H, Offers E, Brüggemann G, et al. Diadenosine phosphates and the physiological control of blood pressure. Nature 1994;307:186-8.
2. 1-adenosine receptors. Br J Pharmacol 1996;119:835-44.
3. Flodgaard H, Klenow H. Abundant amounts of diadenosine 5′,5‴-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets. Biochem J 1982;208:737-42.
4. Baxi MD, Vishwanatha K. Diadenosine polyphosphates: their biological and pharmacological significance. J Pharmacol Toxicol Methods 1995;33:121-8.
5. Busse R, Ogilvie A, Pohl U. Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries. Am J Physiol 1988;245:H828-32.
6. Davies G, MacAllister RJ, Bogle RG, Vallance P. Effects of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors. Br J Clin Pharmacol 1995;40:170-2.
7. Bonaventura C, Cashon R. Alteration of hemoglobin function by diadenosine 5′,5‴-P1-P4-tetraphosphate and other alarmones. J Biol Chem 1992;267:4652-7.
8. Bochner BR, Lee PC, Wilson SW, Cutler CW, Ames BN. APPPPA and related adenylated nucleotides are synthesized as a consequence of oxidation stress. Cell 1984;37:225-32.
9. Kitakaze M, Sekine A, Yamaura T, Nakajima H, Hori M. A novel endogenous vasoactive substance, diadenosine tetraphosphate (AP4A), produced in the ischemic heart as a new vasodilatory mediator. Circulation 1995;92:I-238.
10. 4A), mediates cardioprotection against ischemia and reperfusion injury in the canine heart. Circulation 1995;92:I-524.
11. Hoyle CHV, Ziganshin AU, Pintor J, Burnstock G. The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br J Pharmacol 1996;118:1294-300.
12. Hilderman RH, Martin M, Zimmermann JK. Identification of a unique membrane receptor for adenosine 5′,5‴-P1,P4-tetraphosphate. J Biol Chem 1991;266:6915-8.
13. Walker J, Bossmann P, Lackey BR, Zimmermann JK, Dimmick MA, Hilderman RH. The adenosine 5′,5‴, P1,P4-tetraphosphate receptor is at the cell surface of heart cells. Biochemistry 1993;32:14009-14.
14. Schmitz W, Böhm M, Brückner R, et al. Relationship between the effects of cAMP-increasing agents and adenosine in the mammalian heart. In: Stefanovich V, Rudolphi K, Schubert P, eds. Adenosine: receptors and modulation of cell function. Oxford: IRL Press, 1985:295-302.
15. Scholz H, Böhm R, Brückner R, Neumann J, Schmitz W. Mechanism of the "antiadrenergic" effects of adenosine on the myocardial force of contraction. In: Gerlach E, Becker BE, eds. Topics and perspectives in adenosine research. Berlin: Springer-Verlag, 1987:369-81.
16. Boknik P, Neumann J, Kaspareit G, et al. Mechanisms of the contractile effects of levosimendan in the mammalian heart. J Pharmacol Exp Ther 1997;280:277-83.
17. Heidenreich S, Tepel M, Schlüter H, Harrach B, Zidek W. Regulation of rat mesangial cell growth by diadenosine phosphates. J Clin Invest 1995;95:2862-7.
18. Brückner R, Fenner A, Meyer W, Nobis TM, Schmitz W, Scholz H. Cardiac effects of adenosine and adenosine analogs in guinea-pig atrial and ventricular preparations: evidence against a role of cyclic AMP and cyclic GMP. J Pharmacol Exp Ther 1985;234:766-74.
19. Chiba S, Ogiwara Y, Furukawa Y, Akahane K. Comparative study of cardiovascular effects of clonidine and alinidine in cross-perfused dog atrial preparations. Jpn Heart J 1989;30:895-902.
20. Chiba S. Differences in chronotropic responses of canine atrial muscle and SA node pacemaker activity to adenosine and ACh. Jpn Heart J 1976;17:73-9.
21. Isenberg G, Belardinelli L. Ionic basis for the antagonism between adenosine and isoproterenol on isolated mammalian ventricular myocytes. Circ Res 1984;55:309-25.
22. Kato M, Yamaguchi H, Ochi R. Mechanism of adenosine-induced inhibition of calcium current in guinea-pig ventricular cells. Circ Res 1990;67:1134-41.
23. 2+ transients of isoproterenol-stimulated rat ventricular myocytes. Am J Physiol 1991;261:C1107-14.
24. Seitelberger R, Schütz W, Schlappack O, Raberger G. Evidence against the adenosine-catecholamine antagonism under in vivo conditions. Naunyn Schmiedebergs Arch Pharmacol 1984;325: 234-9.
25. Endoh M, Kushida H, Norota I, Takanashi M. Pharmacological characteristics of adenosine-induced inhibition of dog ventricular contractility: dependence on the preexisting level of β-adrenoceptor activation. Naunyn Schmiedebergs Arch Pharmacol 1991;344: 70-8.
26. + channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins. Pflugers Arch 1985;407: 264-74.
27. 1 receptors by G proteins in rat ventricular myocytes. Am J Physiol 1990;259:H820-6.
28. Linden J, Hollen CE, Patel A. The mechanism by which adenosine and cholinergic agents reduce contractility in rat myocardium: correlation with cyclic adenosine monophosphate and receptor densities. Circ Res 1985;56:728-35.
29. Kubalak SW, Newman WH, Webb JG. Differential effects of pertussis toxin on adenosine and muscarinic inhibition of cAMP accumulation in canine ventricular myocytes. J Mol Cell Cardiol 1991;23:199-205.
30. 6-phenyltsopropyl-adenosine on myocardial inositol phosphate content and force of contraction. Br J Pharmacol 1990;101:829-34.
31. Gupta RC, Neumann J, Watanabe AM. Comparison of purinergic and muscarinic receptor mediated effects on phosphatase inhibitor-I activity in the heart. J Pharmacol Exp Ther 1993;266:16-22.