Toxicological study of the hydroalcoholic extract from Amburana cearensis in rats

Pharmaceutical Biology

Volumn 41, Issue 4, 2003, Pages 308-314

  Leal, L K A M ^a,b   Oliveira, F G ^a   Fontenele, J B ^a   Ferreira, M A D ^a   Viana, G S B ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b NONE   (Brazil)

Author keywords

Amburana cearensis A.C. Smith; Coumarin; Reproduction; Subchronic toxicology

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL DERIVATIVE; ALKALINE PHOSPHATASE; AMBURANA CEARENSIS EXTRACT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; LIPID; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMBURANA; AMBURANA CEARENSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; CONTROLLED STUDY; CREATININE CLEARANCE; DOSE TIME EFFECT RELATION; DRUG ISOLATION; FEMALE; GENDER; LONG TERM EXPOSURE; MALE; MEDICINAL PLANT; NEUTROPHIL; NONHUMAN; PLANT PRODUCT; RAT; REPRODUCTION; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

AMBURANA; AMBURANA CEARENSIS; ANIMALIA; RATTUS NORVEGICUS;

EID: 0041886808     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.41.4.308.15674     Document Type: Article

References (50)

1. Banskota AH, Tezuka Y, Adnyana IK, Xiong Q, Hase K, Kadota S (2000): Hepatoprotective effect of Combretum quadrangulare and its constituents. Biol Pharm Bull 23: 456-460.
2. Basnet P, Kadota S, Shimazu M, Namba T (1994): Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Planta Medi 60: 507-511.
3. Born SL, Caudill D, Smith BJ, Lehman-McKeeman LD (2000): In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity. Toxicol Sci 58: 23-31.
4. Bowers GN, McComb RB (1966): A continuos spectrophotometric method for measuring the activity of serum phosphatase. Clin Chem 12: 70-73.
5. th ed. pp. 219. Imprensa Oficial, Fortaleza, Brasil.
6. Bravo BJA, Sauvain M, Massiot, Gimenez A, Munoz V, Callapa J, Men-Olivier LL, Massiot G, Lavaud C (1999): Bioactive phenolic glycosides from Amburana cearensis. Phytochemistry 50: 71-74.
7. Canuto KM, Silveira ER (2000): Flavonóides de Amburana cearensis (Fr. All.) A. C. Smith (CUMARU). In: XVI Simpósio de Plantas Medicinais do Brasil. Recife, Pernambuco, Brazil.
8. Canuto KM, Silveira ER (1998): Estudo químico de Torresea cearensis Fr. All.(cumaru). In: XV Simpósio de Plantas Medicinais do Brasil. Águas de Lindóia, São Paulo, Brazil.
9. Carlton BD, Aubrun JC, Simon GS (1996): Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and Cd-1 mice. Fund Appl Toxicol 30: 145-151.
10. Casley-Smith JR, Morgan RG, Piller NB (1993): Treatment of lymphedema of the arms and legs with 5,6-benzo(alpha)-pyrone. New Engl J Med 329: 1158-1163.
11. Chung MI, Gan KH, Lin CN, Ko FN, Teng CM (1993): Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants. J Nat Prod 56: 929-934.
12. Cohen AJ (1979): Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man. Food Cosmet Toxicol 17: 277-289.
13. Correa PM (1984): Dicionário de plantas úteis do Brasil edas exóticas cultivadas, vol 2, pp. 474-475, Ministério da Agricultura, Brasília.
14. De Meyer N, Haemers A, Mishra L, Berghe V, Vlietinck AJ (1991): 4′-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. J Med Chem 34: 736-746.
15. Drabkin DL, Austin JH (1932): Spectrophotometric studies, I. spectrophotometric constants for commons hemoglobin derivates in human, dog and rabbit blood. J Biol Chem 177: 751-756.
16. Edwards AJ, Price RJ, Renwick AB, Lake BG (2000): Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay. Food Chem Toxicol 38: 403-409.
17. Evans JG, Appleby EC, Lake BG, Conning DM (1989): Studies on the induction of cholangiofibrosis by coumarin in the rat. Toxicology 55: 207-224.
18. Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR (1995): A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 57: 651-660.
19. Gangolli SD, Shilling WH, Grasso P, Gaunt IF (1974): Studies on the metabolism and hepatotoxicity of coumarin in the baboon. Biochem Soc Trans 2: 310-312.
20. Gartner BC, Seifert CB, Michalk DV, Roth B (1993): Phenprocoumon therapy during pregnancy: case report and comparison of the teratogenic risk of different coumarin derivates. Z Geburtshilfe Perinatol 197: 262-265.
21. Gullsten H, Agundez JA, Benitez J, Laara E, Ladero JM, Diaz-Rub Fernadez Salguero P, Gonzalez F, rautio A, Pelkonen O, Raunio D (1997): CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis. Pharmacogenetics 7: 247-250.
22. Gutmann L, Bergmeyer HU (1974): Methods of Enzymatic Analysis. 2nd ed, pp. 214-216. Verlag Chemic, Academic Press, Washington.
23. Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E (1983): Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen 5 (suppl. 1): 3-142.
24. Henry RJ, Cannon DC, Winkelman JW (1974): Clinical Chemistry: Principles and Techiniques, 2nd ed, pp. 110-120. Harper & Row, New York.
25. Henry RJ, Chiamori N, Golub OJ, Berkman S (1960): Revised spectrophotometric methods for the determination of glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and lactic acid dehydrogenase. Am J Clin Pathol 34: 381-385.
26. Henry JB (1996): Clinical Diagnosis and Management by Laboratory Methods. W.B. Saunders Compant 19th, chapter 13, pp. 279; 280-281, New York.
27. Hoult JRS, Payá M (1996): Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 27: 713-722.
28. Kuster RM, Rocha LM (1999): Farmacognosia-da plan ta medicinal ao medicamento. 1st Ed, chapter 21, Cumarinas, Cromonas e Xantonas, pp. 451. Ed UFSC, Florianópolis, Brasil.
29. Lake BG (1999): Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol 37: 423-453.
30. Leal LKAM, Ferreira AAG, Bezerra GA, Matos FJA, Viana GSB (2000): Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J Ethnopharmacol 70: 151-159.
31. Leal LKAM, Matos ME, Matos FJA, Ribeiro RA, Ferreira FV, Viana GSB (1997): Antinociceptive and antiedematogenic effects of the hydroalcoholic extract and coumarin from Torresea cearensis Fr. All. Phytomedicine 4: 221-227.
32. Lin CN, Hsieh HK, Liou SJ, Ko HH, Lin HC, Chung MI, Ko FN, Liu HW, Teng CM (1996a): Synthesis and antithromboric effect of xanthone derivates. J Pharm Pharmacol 48: 887-890.
33. Lin CN, Liou SJ, Lee TH, Chuang YC, Won SJ (1996b): Xanthones derivaties as potential anti-cancer drugs. J Pharm Pharmacol 48: 539-544.
34. Loprinzi CL, Kugler JW, Sloan JA, Rooke TW, Quella SK, Novotny P, Mowat RB, Michalak JC, Stella PJ, Levitt R, Tschetter LK, Windschitl H (1999): Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. N Engl J Med 340: 346-350.
35. Martin-Aragón S, Benedi J, Villar A (1996): Oxygen active species-scavenger properties of coumarins. Phytother Res 10: 575-578.
36. Neuhaus-Carlisle K, Vierling W, Wagner H (1997): Screening of plant extracts and plant constituents for calcium-channel blocking activity. Phytomedicine 4: 67-69.
37. 1 mice (gavage studies). National Toxicology Program. Technical Report No. 93-3153. US Department of Health and Human Services, NIH, Research triangle Park, NC.
38. Opdyke DLJ (1974): Monographs on fragrance raw materials: Coumarin. Fd Cosmet. Toxicol 12: 385.
39. Reynolds JEF (1996): Martindale: The Extra Pharmacopoeia. 30 ed, Pharmaceutical Press, London.
40. Robbers JE, Tyler VE, Speedie MR (1997): Farmacognosia e Farmacobiotecnologia. Chapter 8, Fenilpropanóides, pp. 153-155, Ed Premier, São Paulo, Brasil.
41. Rocha D (1945): Formulário Therapeutico de Plantas Medicinais Cearenses Nativas e Cultivadas, pp. 45, Ed Progresso, Fortaleza, Brasil.
42. Shilling WH, Crampton RF, Longland RC (1969). Metabolism of coumarin in man. Nature 221: 664-665.
43. Soine TO (1964): Naturally occurring coumarins and related physiological activities. Pharm Sci 53: 231-264.
44. Struwe FE, Reinwein H, Stier R (1984): Coumarin embryopathy. Radiologe 24: 68-71.
45. Tanaka AS, Sampaio MU, Marangoni S, de Oliveira B, Novello JC, Oliva ML, Fink E, Sampaio CA (1997): Purification and primary structure determination of a Bowman-Birk trypsin inhibitor from Torresea cearensis seeds. J Biol Chem 378: 273-281.
46. Trinder P (1969): Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 6: 24-25.
47. Wang Y, Hamburger M, Gueho J, Hostettmam K (1989): Antimicrobial flavonoids from Psidia trinervia and their methylated and acetylated derivatives. Phytochemistry 28: 2323-2327.
48. Williams WJ, Beutler E, Erslev AJ, Rundles RW (1976): Hemathologia. Guanabara Koogan, Rio de Janeiro, Brasil, pp. 58-70.
49. Wintrobe MM (1981): Clinical Hematology. 8th ed, pp. 215-230. Lea & Fabinger, Philadelphia.
50. Zipprich K, Canzler E, Hundsdorfer S (1987): Teratogenic effect of coumarins. Zentralbl Gynakol 109: 364-368.