Aralin, a new cytotoxic protein from Aralia elata, inducing apoptosis in human cancer cells

Cancer Letters

Volumn 199, Issue 1, 2003, Pages 19-25

  Tomatsu, Makoto ^a   Ohnishi Kameyama, Mayumi ^b   Shibamoto, Norio ^a  

^a Akita Research Institute of Food and Brewing   (Japan)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Apoptosis; Aralia elata; Aralin; Cytotoxicity; Human cancer cells

Indexed keywords

ARALIA ELATA EXTRACT; CASPASE INHIBITOR; DNA FRAGMENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARALIA; ARALIA ELATA; ARTICLE; CANCER CELL; CELL STRAIN HL 60; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG SENSITIVITY; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; LUNG FIBROBLAST; LYMPHOCYTE CULTURE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN PURIFICATION; SHOOT; UTERINE CERVIX CARCINOMA;

ARALIA; ARALIA ELATA;

EID: 0041878896     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00348-3     Document Type: Article

References (27)

1. Oka M., Hazama S., Suzuki M., Wang F., Wadamori K., Iizuka N., Takeda S., Akitomi Y., Ohba Y., Kajiwara K., Suga S., Suzuki T. In vitro and in vivo analysis of human leukocyte binding by the antitumor polysaccharide, lentinan. Int. J. Immunopharmacol. 18:1996;211-216.
2. Furusawa E., Furusawa S. Anticancer activity of a natural product, Viva-Natural, extracted from Undaria pinnantifida on intraperitoneally implanted Lewis lung carcinoma. Oncology. 42:1985;364-369.
3. Furusawa E., Furusawa S. Anticancer potential of Viva-Natural, a dietary seaweed extract, on Lewis lung carcinoma in comparison with chemical immunomodulators and on cyclosporine-accelerated AKR leukemia. Oncology. 46:1989;343-349.
4. Itoh H., Noda H., Amano H., Zhuaug C., Mizuno T., Itoh H. Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res. 13:1993;2045-2052.
5. Chihara G., Hamuro J., Maeda Y., Shiio T., Suga T., Takasuka N., Sasaki T. Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. Cancer Detect. Prev. Suppl. 1:1987;423-443.
6. Sundaram S.G., Milner J.A. Diallyl disulfide induces apoptosis of human colon tumor cells. Carcinogenesis. 17:1996;669-673.
7. Sakamoto K., Lawson L.D., Milner J.A. Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells. Nutr. Cancer. 29:1997;152-156.
8. Milner J.A. Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation: garlic and carcinogenesis. Adv. Exp. Med. Biol. 492:2001;69-81.
9. Davis B.J. Disc electrophoresis. II. Method and application to human serum proteins. Ann. NY Acad. Sci. 121:1964;404-427.
10. Iijima Y., Ogawa K., Watanabe N., Usui T., Kameyama M.O., Nagata T., Sakata K. Characterization of β-primeverosidase, being concerned with alcoholic aroma formation in tea leaves to be processed into black tea, and preliminary observations on its substrate specificity. J. Agric. Food Chem. 46:1998;1712-1718.
11. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
12. O'Farrell P.H. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250:1975;4007-4021.
13. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
14. Hirano H., Watanabe T. Microsequencing of proteins electrotransferred onto immobilizing matrices from polyacrylamide gel electrophoresis: application to an insoluble protein. Electrophoresis. 11:1990;573-580.
15. McConkey D.J., Hartzell P., Chow S.C., Orrenius S., Londal M. Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes. J. Biol. Chem. 265:1990;3009-3011.
16. Ryu S.Y., Ahn J.W., Han Y.N., Han B.H., Kim S.H. In vitro antitumor activity of diterpenes from Aralia cordata. Arch. Pharm. Res. 19:1996;77-78.
17. Yoshikawa M., Murakami T., Harada E., Murakami N., Yamahara J., Matsuda H. Bioactive saponins and glycosides. VI. Elatosides A and B, potent inhibitors of ethanol absorption, from the bark of Aralia elata SEEM. (Araliaceae): the structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity. Chem. Pharm. Bull. 44:1996;1915-1922.
18. Yoshikawa M., Yoshizumi S., Ueno T., Matsuda H., Murakami T., Yamahara J., Murakami N. Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff 'Taranome', the young shoot of Aralia elata SEEM: elatosides G, H, I, J, and K. Chem. Pharm. Bull. 43:1995;1878-1882.
19. Olsnes S. Ricin and ricinus agglutinin, toxic lectins from castor bean. Meth. Enzymol. 50:1978;330-335.
20. Lord J.M., Roberts L.M., Robertus J.D. Ricin: structure, mode of action, and some current applications. FASEB J. 8:1994;201-208.
21. Girbés T., Citores L., de Beneito F.M., Iglesias R., Ferreras J.M. A non-toxic two-chain ribosome-inactivating protein co-exists with a structure-related monomeric lectin (SNA III) in elder (Sambucus nigra) fruit. Biochem. J. 315:1996;343-344.
22. Muñoz R., Arias Y., Ferreras J.M., Jiménez P., Rojo M.A., Girbés T. Sensitivity of cancer cell lines to the novel non-toxic type 2 ribosome-inactivating protein nigrin b. Cancer Lett. 167:2001;163-169.
23. Nicholson D.W., Thornberry N.A. Caspase: killer proteases. TIBS Rev. 22:1997;299-306.
24. Villa P., Kaufmann S.H., Earnshaw W.C. Caspases and caspase inhibitors. TIBS Rev. 22:1997;388-393.
25. Zhivotovski B., Gahm A., Ankarcroma M., Nicotera P., Orrenius S. Multiple proteases are involved in thymocyte apoptosis. Exp. Cell Res. 221:1995;404-412.
26. Komatsu N., Oda T., Muramatsu T. Involvement of both caspase-like proteases and serine proteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and Pseudomonas toxin. J. Biochem. 124:1998;1038-1044.
27. Rowel S.J., Allen L., Ridger V.C., Hellwell P.G., Whyte M.K. Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J. Immunol. 169:2002;6401-6407.