Nocardia asteroides Culture Filtrates Cause Dopamine Depletion and Cytotoxicity in PC12 Cells

Neurochemical Research

Volumn 28, Issue 9, 2003, Pages 1359-1367

  Camp, Dianne M ^a   Loeffler, David A ^a   Razoky, Bnan A ^a   Tam, Stanley ^b   Beaman, Blaine L ^b   LeWitt, Peter A ^a,c  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dopamine; Monoamines; Neurotoxins; Nocardia; Parkinson's disease; PC12 cells

Indexed keywords

BACTERIAL TOXIN; BRAIN MONOAMINE; DOPAMINE; NEUROTOXIN; BIOLOGICAL FACTOR; CATECHOLAMINE;

ANIMAL CELL; ARTICLE; BACTERIUM CULTURE; CELL COUNT; CELL INFILTRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; EXPERIMENTAL INFECTION; GLIOMA CELL; IN VITRO STUDY; INCUBATION TIME; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NEUROTOXICITY; NOCARDIA ASTEROIDES; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; STRIATONIGRAL DEGENERATION; ANIMAL; CELL STRAIN; CELL SURVIVAL; COMPARATIVE STUDY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; FILTRATION; GLIA; ISOLATION AND PURIFICATION; METABOLISM; NERVE CELL; TIME;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); NOCARDIA; NOCARDIA ASTEROIDES; POSIBACTERIA; UNCULTURED ACTINOMYCETE;

ANIMALS; BIOLOGICAL FACTORS; CATECHOLAMINES; CELL SURVIVAL; CULTURE MEDIA; DOPAMINE; FILTRATION; NEUROGLIA; NEURONS; NEUROTOXINS; NOCARDIA ASTEROIDES; PC12 CELLS; RATS; TIME FACTORS;

EID: 0041878724     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024944431725     Document Type: Article

References (34)

1. Beaman, B. L. and Beaman, L. 1994. Nocardia species: Host-parasite relationships. Clin. Microbiol. Rev. 7:213-264.
2. Beaman, B. L. 1992. Nocardia: An environmental bacterium possibly associated with neurodegenerative diseases in humans. Pages 147-166, in Isaacson, R. L. and Jensen, K. (eds.), The vulnerable brain and environmental risks. Vol. 2. Toxins in food. New York, Plenum Press.
3. Smith, P. W., Steinkraus, G. E., Hendricks, B. W., and Madson, E. C. 1980. CNS nocardiosis response to sulfamethoxazoletrimethoprim. Arch. Neurol. 37:729-730.
4. Ogata, S. A. and Beaman, B. L. 1992. Adherence of Nocardia asteroides within the murine brain. Infect. Immun. 60:1800-1805.
5. Beaman, B. L. 1993. Ultrastructural analysis of growth of Nocardia asteroides during invasion of the murine brain. Infect. Immun. 61:274-283.
6. Ogata, S. A. and Beaman, B. L. 1992. Site-specific growth of Nocardia asteroides in the murine brain. Infect. Immun. 60:3262-3267.
7. Kohbata, S. and Beaman, B. L. 1991. L-DOPA-responsive movement disorder caused by Nocardia asteroides localized in the brains of mice. Infect. Immun. 59:181-191.
8. Beaman, B. L. 1982. Nocardiosis: Role of the cell wall deficient state of Nocardia. Pages 231-255, in Domingue, G. J. (ed.), Cell wall defective bacteria: Basic principles and clinical significance. Reading, MA, Addison-Wesley.
9. Beaman, B. L. and Scates, S. M. 1981. Role of L-forms of Nocardia caviae in the development of chronic mycetomas in normal and immunodeficient murine models. Infect. Immun. 33: 893-907.
10. Hyland, K., Beaman, B. L., LeWitt, P. A., and DeMaggio, A. J. 2000. Monoamine changes in the brain of BALB/c mice following sub-lethal infection with Nocardia asteroides (GUH-2). Neurochem. Res. 25:443-448.
11. Tam, S., Barry, D. P., Beaman, L., and Beaman, B. L. 2002. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Exp. Neurol. 177:453-460.
12. Pothos, E., Desmond, M., and Sulzer, D. 1996. L-3,4- Dihydroxyphenylalanine increases the quantal size of exocytotic dopamine release in vitro. J. Neurochem. 66:629-636.
13. Presse, F., Cardona, B., Borsu, L., and Nahon, J. L. 1997. Lithium increases melanin-concentrating hormone mRNA stability and inhibits tyrosine hydroxylase gene expression in PC12 cells. Brain Res. Molec. Brain Res. 52:270-283.
14. Zachor, D. A., Moore, J. F., Brezausek, C., Theibert, A., and Percy, A. K. 2000. Cocaine inhibits NGF-induced PC12 cells differentiation through Dl-type dopamine receptors. Brain Res. 869:85-97.
15. Greene, L. A. and Tischler, A. S. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73:2424-2428.
16. Beaman, B. L. and Moring, S. E. 1988. Relationship among cell wall composition, stage of growth and virulence of Nocardia asteroides GUH-2. Infect. Immun. 56:557-563.
17. Loeffler, D. A., Camp, D. M., and LeWitt, P. A. 2000. Purine-induced alterations of dopamine metabolism in PC12 rat pheochromocytoma cells. Brain Res. Bull. 52:553-558.
18. Robinson, T. E. and Camp, D. M. 1991. The feasibility of repeated microdialysis for within-subjects design experiments: Studies on the mesostriatal dopamine system. Pages 189-234, in Robinson, T. E. and Justice, J. B. (eds.), Microdialysis in the neurosciences. Amsterdam, Elsevier Press.
19. Tam, S., Pujic, P., Beaman, L., Barry, D. P., and Beaman, B. E. 2001. Nocardia asteroides induces apoptotic cell death. Pages 83-89, in American Society for Microbiology 101st general meeting abstracts. Washington, D. C., American Society for Microbiology.
20. Oberdoerster, J. and Rabin, R. A. 1999. NGF-differentiated and undifferentiated PC12 cells vary in induction of apoptosis by ethanol. Life Sci. 64:267-272
21. Sasaki, N., Baba, N., and Matsui, M. 2001. Cytotoxicity of reactive oxygen species and related agents toward undifferentiated and differentiated rat pheochromocytoma PC12 cells. Biol. Pharm. Bull. 24:515-519.
22. Di Monte, D. A., Wu, E. Y., Delanney, L. E., Irwin, I., and Langston, J. W. 1992. Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. J. Pharmacol. Exp. Ther. 261:44-49.
23. Lotharius, J., Dugan, L. L., and O'Malley, K. L. 1999. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19:1284-1293.
24. Blum, D., Torch, S., Nissou, M.-F., Benabid, A.-L., and Verna, J.-M. 2000. Extracellular toxicity of 6-hydroxydopamine on PC12 cells. Neurosci. Lett. 283:193-196.
25. Ungerstedt, U. 1968. 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur. J. Pharmacol. 5:107-110.
26. Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M., and Kopin, I. J. 1983. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3.6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80:4546-4550.
27. Beaman, B. L., Canfield, D., Anderson, J., Pate, B., and Calne, D. 2000. Site specific invasion of the basal ganglia by Nocardia asteroides GUH-2. Med. Microbiol. Immunol. 188:161-168.
28. Floor, E. and Wetzel, M. G. 1998. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. J. Neurochem. 70:268-75.
29. Beaman, B. L., Scates, S. M., Moring, S. E., Deem, R., and Misra, H. P. 1983. Purification and properties of a unique superoxide dismutase from Nocardia asteroides. J. Biol. Chem. 258:91-96.
30. Ioneda, T., Niigaki, N. T., Dealmeida, E. T., and Levy, C. E. 1989. Occurrence of trehalose mycolate as the major lipidic component carrying toxic property in clinical Nocardia isolates. Rev. Microbiol. 20:345-348.
31. Tamplin, M. L. and McClung, N. M. 1984. Quantitative studies of the relationship between trehalose lipids and virulence of Nocardia asteroides isolates. Pages 251-258, in Ortiz-Ortiz, L., Bojalil, L. F., and Yakoleff, V. (eds.), Biological, Biochemical and Biomedical Aspects of Actinomycetes. Orlando, Academic Press.
32. Emerueva, A. C. 1986. Isolation and some properties of beta-hemolysis produced by Nocardia asteroides. Mycopathologia 95:29-35.
33. Mikami, Y., Yu, S. F., Yazawa, K., Fukishima, K., Maeda, A., Uno, J., Terao, K., Saito, N., Kubo, A., and Suzuki, K. 1990. A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis. Mycopathologia 112:113-118.
34. Hubble, J. P., Cao, T., Kjelstrom, J. A., Koller, W. C., and Beaman, B. L. 1995. Nocardia species as an etiologic agent in Parkinson's disease: Serological testing in a case-control study. J. Clin. Microbiol. 33:2768-2769.