The contribution of signaling pathways to olfactory organization and development

Current Opinion in Neurobiology

Volumn 13, Issue 4, 2003, Pages 482-486

  Reed, Randall R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; PROTEIN SUBUNIT; RECEPTOR PROTEIN;

ACCURACY; CALCIUM TRANSPORT; DENDRITE; EMBRYO DEVELOPMENT; GENETIC MANIPULATION; GENETIC MODEL; GLOMERULUS; MAMMAL; NERVE PROJECTION; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NONHUMAN; ODOR; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY NERVOUS SYSTEM; OLFACTORY RECEPTOR; PERINATAL DEVELOPMENT; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SENSE ORGAN; SENSORY NERVE CELL; SENSORY SYSTEM; SIGNAL TRANSDUCTION; STEREOTYPY; X CHROMOSOME;

EID: 0041878296     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(03)00104-1     Document Type: Review

References (32)

1. Mori K., Nagao H., Yoshihara Y. The olfactory bulb: coding and processing of odor molecule information. Science. 286:1999;711-715.
2. Shepherd G: The Synaptic Organization of the Brain. Oxford UK: Oxford University Press; 1998.
3. Chess A., Simon I., Cedar H., Axel R. Allelic inactivation regulates olfactory receptor gene expression. Cell. 78:1994;823-834.
4. Malnic B., Hirono J., Sato T., Buck L.B. Combinatorial receptor codes for odors. Cell. 96:1999;713-723.
5. Ressler K.J., Sullivan S.L., Buck L.B. A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell. 73:1993;597-609.
6. Vassar R., Ngai J., Axel R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell. 74:1993;309-318.
7. Treloar H.B., Feinstein P., Mombaerts P., Greer C.A. Specificity of glomerular targeting by olfactory sensory axons. J Neurosci. 22:2002;2469-2477.
8. Vassar R., Chao S.K., Sitcheran R., Nunez J.M., Vosshall L.B., Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell. 79:1994;981-991.
9. Ressler K.J., Sullivan S.L., Buck L.B. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 79:1994;1245-1255.
10. Mombaerts P., Wang F., Dulac C., Chao S.K., Nemes A., Mendelsohn M., Edmondson J., Axel R. Visualizing an olfactory sensory map. Cell. 87:1996;675-686.
11. Wang F., Nemes A., Mendelsohn M., Axel R. Odorant receptors govern the formation of a precise topographic map. Cell. 93:1998;47-60.
12. Bozza T., Feinstein P., Zheng C., Mombaerts P. Odorant receptor expression defines functional units in the mouse olfactory system. J Neurosci. 22:2002;3033-3043 The authors demonstrate that olfactory receptors are major determinants of axonal targeting and the specification of ligand sensitivity.
13. Graziadei P.P. Cell dynamics in the olfactory mucosa. Tissue Cell. 5:1973;113-131.
14. Graziadei PPC, Monti-Graziadei GA: The Olfactory System: A Model for the Study of Neurogenesis and Axon Regeneration in Mammals. Edited by Cotman CW. New York: Raven Press; 1978.
15. Graziadei P.P., Graziadei G.A. Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons. J Neurocytol. 8:1979;1-18.
16. Mackay-Sim A., Kittel P. Cell dynamics in the adult mouse olfactory epithelium: a quantitative autoradiographic study. J Neurosci. 11:1991;979-984.
17. Katz L.C., Shatz C.J. Synaptic activity and the construction of cortical circuits. Science. 274:1996;1133-1138.
18. Reed R.R. Signaling pathways in odorant detection. Neuron. 8:1992;205-209.
19. Belluscio L., Gold G.H., Nemes A., Axel R. Mice deficient in G(olf) are anosmic. Neuron. 20:1998;69-81.
20. Wong S.T., Trinh K., Hacker B., Chan G.C., Lowe G., Gaggar A., Xia Z., Gold G.H., Storm D.R. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 27:2000;487-497.
21. Trinh K., Storm D.R. Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium. Nat Neurosci. 6:2003;519-525 The authors of this study describe the aberrant axonal projections of adenylyl cyclase type III -null mice.
22. Brunet L.J., Gold G.H., Ngai J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron. 17:1996;681-693.
23. Baker H., Cummings D.M., Munger S.D., Margolis J.W., Franzen L., Reed R.R., Margolis F.L. Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice. J Neurosci. 19:1999;9313-9321.
24. Murphy G.J., Isaacson J.S. Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb. Neuron. 37:2003;639-647 An additional role for the cyclic nucleotide-gated ion channel in modulating synaptic transmission in the bulb is first described in this paper.
25. Malun D., Brunjes P.C. Development of olfactory glomeruli: temporal and spatial interactions between olfactory receptor axons and mitral cells in opossums and rats. J Comp Neurol. 368:1996;1-16.
26. Lin D.M., Wang F., Lowe G., Gold G.H., Axel R., Ngai J., Brunet L. Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron. 26:2000;69-80.
27. Conzelmann S., Malun D., Breer H., Strotmann J. Brain targeting and glomerulus formation of two olfactory neuron populations expressing related receptor types. Eur J Neurosci. 14:2001;1623-1632 The authors genetically tagged highly homologous olfactory receptors to examine their targeting in the olfactory bulb. They found that refinement of the projections occurs in a rapid time course after birth.
28. Zheng C., Feinstein P., Bozza T., Rodriguez I., Mombaerts P. Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron. 26:2000;81-91.
29. Zhao H., Reed R.R. X inactivation of the OCNC1 channel gene reveals a role for activity- dependent competition in the olfactory system. Cell. 104:2001;651-660 The authors use the random inactivation of the X chromosome in a genetic model to establish competition between normal and channel deficient olfactory neurons. This study reveals a competitive disadvantage and gradual loss of inactive cells. This specific depletion can be reversed by odorant deprivation.
30. Liu W.L., Shipley M.T. Intrabulbar associational system in the rat olfactory bulb comprises cholecystokinin-containing tufted cells that synapse onto the dendrites of GABAergic granule cells. J Comp Neurol. 346:1994;541-558.
31. Belluscio L., Lodovichi C., Feinstein P., Mombaerts P., Katz L.C. Odorant receptors instruct functional circuitry in the mouse olfactory bulb. Nature. 419:2002;296-300 The authors demonstrate the specificity of intrabulbar tufted cell projections. They use a combination of genetically modified mice and focal dye injection to reveal exquisite targeting in this bulb circuit.
32. Lodovichi C., Belluscio L., Katz L.C. Functional topography of connections linking mirror-symmetric maps in the mouse olfactory bulb. Neuron. 38:2003;265-276 The authors extend their initial findings on intrabulbar tufted cell projections to demonstrate reciprocal connectivity.