Synthesis and chiral separation of dinucleotide(TpAZT) phosphoramidates

Chinese Chemical Letters

Volumn 14, Issue 8, 2003, Pages 779-782

  Lin, Chang Xue ^a   Fu, Hua ^a   Tu, Guang Zhong ^b   Zhao, Yu Fen ^a  

^a TSINGHUA UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROCHEMISTRY   (China)

Author keywords

Chiral auxiliary; Chiral separation; Dinucleotide phosphoramidate

Indexed keywords

ALANINE; DINUCLEOTIDE; ESTER DERIVATIVE; PHENYLALANINE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHIRALITY; CRYSTALLIZATION; SEPARATION TECHNIQUE; STEREOISOMERISM; SYNTHESIS; TODD REACTION;

EID: 0041877425     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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12. 3CN solution at room temperature gave product 4. Product 5 was obtained as white foam after 5′-deprotection of 4 in formic acid and purification on silica gel column chromatography.