Effect of ionizing radiation on the expression of p16, CyclinD1 and CDK4 in mouse thymocytes and splenocytes 1

Biomedical and Environmental Sciences

Volumn 16, Issue 1, 2003, Pages 47-52

  Ju, Gui Zhi ^a   Wang, Xiao Mei ^a   Fu, Shi Bo ^a   Liu, Shu Zheng ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

CDK4; Cyclind1; Ionizing radiation; Thymocytes and splenocytes

Indexed keywords

CDK4 PROTEIN, MOUSE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; ONCOPROTEIN; PROTEIN P16INK4A;

ANIMAL; ARTICLE; BIOSYNTHESIS; CYTOLOGY; FLOW CYTOMETRY; MALE; METABOLISM; MOUSE; MOUSE STRAIN; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SPLEEN; THYMUS; X RAY;

ANIMALS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; MALE; MICE; MICE, INBRED STRAINS; PROTO-ONCOGENE PROTEINS; RADIATION DOSAGE; SPLEEN; THYMUS GLAND; X-RAYS;

EID: 0041843607     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Wang, X.Q., Gabrielli, B.G., Milligan, A., Dickinson, J.L., Antalis, T.M., and Ellem, K.A.O. (1996). Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with a late S-G2 phase cell cycle delay. Cancer Res. 56, 2510-2514.
2. Milligan, A., Gabrilli, B.G., Clark, J.M., Hayward, N.K., and Ellem, K.A.O. (1998). Involvenment of p16CDKN2A in cell cycle delays after low dose UV irradiation. Mutation Res. 433, 43-53.
3. Serrano, M., Hannon, G.J., and Beach, D. (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366, 704-707.
4. Sherr, C.J. and Roberts, J.M. (1995). Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
5. Pavey, S., Conroy, S., Russell, T., and Gabrielli, B. (1999). Ultraviolet radiation induces p16CDKN2A expression in human skin. Cancer Res. 59, 4185-4189.
6. Ahmed, N.U., Ueda, M., and Ichihashi, M. (1999). Induced expression of p16 and p21 proteins in UVB-irradiated human epidermis and cultured keratinocytes. J. Dermatol Sci. 19, 175-181.
7. 2 phase delay. J. Biol. Chem. 274, 13961-13969.
8. Piepkorn, M. (2000). The expression of p16 (INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation. J. Am. Acad. Dermatol. 42, 741-745.
9. Diehl, J.A., Zindy, F., and Sherr, C.J. (1997). Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11, 957-972.
10. Tam, S.W., Shay, J.W., and Pagano, M. (1994). Differential expression and cell cycle regulation of the cyclin dependent kinase 4 inhibitor p16INK4. Cancer Res. 54, 5816-5820.
11. Shapiro, G.I., Edwards, C.D., and Rollins, B.J. (2000). The physiology of p16(INK4A)-mediated G1 proliferative arrest. Cell Biochem. Biophys. 33, 189-197.
12. Ju, G.Z., Fu, H.Q., Fu, S.B., and Liu, S.Z. (2001). G1 Arrest and relative protein expressions in mouse thymocytes induced by WBI. Biomed. Environ. Sci. 14, 27-31.