Protonation equilibrium and lipophilicity of olamufloxacin (HSR-903), a newly synthesized fluoroquinolone antibacterial

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 56, Issue 2, 2003, Pages 223-229

  Sun, Jin ^a,b   Sakai, Shigeko ^a   Tauchi, Yoshihiko ^a   Deguchi, Yoshiharu ^a   Cheng, Gang ^b   Chen, Jimin ^b   Morimoto, Kazuhiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apparent partition coefficient; Ion pairing; Micro dissociation constant; Olamufloxacin; Protonation equilibrium

Indexed keywords

CARBOXYL GROUP; CIPROFLOXACIN; LEVOFLOXACIN; NQ 762; OLAMUFLOXACIN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CALCULATION; DISSOCIATION CONSTANT; ION PAIR EXTRACTION; IONIZATION; ISOELECTRIC POINT; LIPID SOLUBILITY; NONLINEAR SYSTEM; PARTITION COEFFICIENT; PH MEASUREMENT; PROTON TRANSPORT; REGRESSION ANALYSIS; ULTRAVIOLET RADIATION;

EID: 0041834838     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00099-7     Document Type: Article

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