Effect of route of administration on the disposition of acrylonitrile: Quantitative whole-body autoradiographic study in rats

Pharmacological Research

Volumn 48, Issue 5, 2003, Pages 479-488

  Jacob, Sam ^a   Ahmed, Ahmed E ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Acrylonitrile; Covalent binding; Disposition; Quantitative whole body autoradiography; Route of administration; Toxicity

Indexed keywords

ACRYLONITRILE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CHEMICAL INTERACTION; CONTROLLED STUDY; COVALENT BOND; DOSE RESPONSE; EXPIRED AIR; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TISSUE LEVEL; TOXICITY; URINARY EXCRETION; URINE RETENTION; WHOLE BODY AUTORADIOGRAPHY;

EID: 0041826996     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00192-0     Document Type: Article

References (39)

1. Reish M.S. Top 50 chemical production stagnated last year. Chem. Eng. News. 70:1992;16-19.
2. Quast J.F., Enviguez R.M., Wade C.M., Humiston C.G., Schwetz B.A. Toxicity of drinking water containing acrylonitrile (AN) in rats. Fed. Reg. 43:1978;2489.
3. Qast JF, Schuetz DJ, Balmer MF, Gushow TS, Park CN, McKenna MJ. A two-year carcinogenicity study with acrylonitrile following inhalation exposure to rats. Final report. Midland, MI: Dow Toxicology Research Laboratory; 1980.
4. International Agency for Research on Cancer (IARC). Monographs on the evaluation of carcinogenic risks to humans. Some monomers, plastics and synthetic elastomers, and acrolein. 1979;19:513.
5. International Agency for Research on Cancer (IARC). Monographs on the evaluation of carcinogenic risks to humans. Genetic and related effects: an updating of selected IARC monographs. 1987;1-42 (Suppl 6):27-31.
6. International Agency for Research on Cancer (IARC). Acrylonitrile. Part I. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 71. Lyon, France; 1999. p. 43-108.
7. DPIM Rep. No. 5. In: Sax NI, editor. Dangerous properties of industrial materials report, vol. 7. New York, NY: Van Nostrand Reinhold Company, Inc.; 1987.
8. Environmental Protection Agency. Health assessment documents for acrylonitrile. Final report; 1983. EPA 600/8-82-007F.
9. O'Berg M.T., Chen J.L., Burke C.A., Walrath J., Pell S. Epidemiologic studies of workers exposed to acrylonitrile: an update. J. Occup. Med. 27:1985;835-840.
10. Ward C.E., Starr T.B. Comparison of cancer risks projected from animal bioassays to epidemiologic studies of acrylonitrile exposed workers. Regul. Toxicol. Pharmacol. 18:1993;214-232. (doi:10. 1006/rtph. 1993. 1055).
11. O'Berg M.T. Epidemiological studies of workers exposed to acrylonitrile. J. Occup. Med. 22:1980;245.
12. Maltoni C., Ciliberti A., Maio D.V. Carcinogenicity bioassays on rats of acrylonitrile by inhalation and by ingestion. Med. Lavoro. 68:1977;401.
13. Bigner D.D., Bigner S.H., Burger P.C., Shellburne J.D., Friedman H.S. Primary brain tumors in Fischer 344 rats chronically exposed to acrylonitrile in the drinking water. Food Chem. Toxicol. 24:1986;129-137.
14. Szabo S., Huttner I., Kovacs K.E., Horvath D., Szabo D., Horner H.C. Pathogenesis of experimental adrenal hemorrhagic necrosis ("apoplexy" ). Ultrastructural, biochemical, neuropharmacological and blood coagulation studies with acrylonitrile in the rat. Lab. Invest. 42:1980;533.
15. Dudley H.C., Neal D.A. Toxicology of acrylonitrile (vinyl cyanide). Part 1. A study of the acute toxicity. J. Ind. Hyg. Toxicol. 24:1942;27.
16. Paulet G., Desnos J. Acrylonitrile toxicity, mechanism of action, therapeutic uses. Arch. Int. Pharmacodyn. 131:1961;54.
17. Abreu M.E., Ahmed A.E. Metabolism of acrylonitrile to cyanide in vitro studies. Drug. Metab. Dispos. 8(6):1980;376.
18. Brieger H., Rieders F., Hodes W.A. Acrylonitrile spectrophotometric determination of acute toxicity and mechanism of action. Arch. Ind. Hyg. 6:1952;128.
19. 14C metabolism in rats: effect of route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and feces J. Hyg. Epidem. Microbiol. Immunol. 25:1981;12.
20. Roberts A.E., Lacy S.A., Pilon D., Turner M.J., Rickert D.E. Metabolism of acrylonitrile to 2-cyanoethylene oxide in F-344 rat liver microsomes, and lung cells. Drug. Metab. Dispos. 17:1988;481.
21. Kedderis G.L., Batra R., Turner M.J. Conjugation of acrylonitrile with hepatic glutathione. Toxicol. Appl. Pharmacol. 135:1995;9-17.
22. Benes V., Cerna V. Acrylonitrile: acute toxicity and working mechanisms. J. Hyg. Epidem. 3:1959;106.
23. Gut J., Nerndova J., Kopecky F., Holeck V. Acrylonitrile biotransformation in rats, mice and Chinese hamsters influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate. Arch. Toxicol. 33:1975;151.
24. Silver E.H., Kuttab S.H., Hasan T., Hasan M. Structural considerations in the metabolism of nitriles to cyanide in vivo. Drug. Metab. Dispos. 10:1982;495.
25. Kedderis G.L., Sumner S.C., Held S.C., Batra R., Turner M.J., Fennel T.R. Dose dependent urinary excretion of acrylonitrile metabolism in rats and mice. Toxicol. Appl. Pharmacol. 120:1993;288-297. (doi:10. 1006/taap. 1993. 1114).
26. Tardif R., Talbot D., Gerin M., Brodeur J. Urinary excretion of mercapturic acids and thiocyanate in rats exposed to acrylonitrile: influence of dose and route of administration. Toxicol. Lett. 39:1987;255.
27. 14C ]-acrylonitrile in the rat J. Appl. Toxicol. 3:1983;39.
28. 14C ]-acrylonitrile in rat and monkey Toxicol. Lett. 6(3):1980;187-191.
29. 14C ]-acrylonitrile in rat after single injection Ecotoxicol. Environ. Safety. 6(5):1982;489-494.
30. 14C ]-thymidine in mice J. Pharmacol. Exp. Ther. 257(1):1991;479.
31. Ullberg, S. The technique of whole body autoradiography. Cryosection of large specimens. Special issue on whole body autoradiography. Science Tools, 1977. LKB Instrum J (Uppsaala, Sweden).
32. 3H ]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies Cancer Chemother. Pharmacol. 39:1996;122-130.
33. Ahmed A.E., Jacob S., Au W.W. Quantitative whole body autoradiographic disposition of glycol ether in mice: effect of route of administration. Fundam. Appl. Toxicol. 22:1994;266. (doi:10. 1006/faat.1994.1030).
34. Ahmed A.E., Jacob S., Ghanayem B.I. Comparative disposition of acrylonitrile and methacrylonitrile: quantitative whole-body autoradiographic studies in rats. Funadm. Appl. Toxicol. 33:1996;49-59. (doi:10. 1006/faat. 1996. 0142).
35. Ahmed A.E., Jacob S., Giovanella B.C., Kozhielski A.J., Liehr J.G., Stehlin J.S. Comparative disposition of the antineoplastic agent 9-nitro camptothecin and the inactive isomer 12-nitro camptothecin in CASE-bearing nude mice: effect of route of administration on tissue distribution. Cancer Chemother. Pharmacol. 41:1997;29-36.
36. Peter H., Bolt H.M. Irreversible protein binding of acrylonitrile. Xenobiotica. 11:1981;51.
37. Ghanayem B.I., Ahmed A.E. Acrylonitrile induced gastrointestinal hemorrhage and the effects of metabolism modulation in rats. Toxicol. Appl. Pharmacol. 68:1983;290-296.
38. Abdel-Rahman S.Z., Nouraldeen A.M., Ahmed A.E. Molecular interaction of acrylonitrile with DNA in gastric tissue of rat. J. Biochem. Toxicol. 9:1994;191-197.
39. Ahmed A.E., Abdel-Aziz A.H., Abdel-Rahman S.Z., Haque A.K., Nouraldeen A.M., Shouman S.A. Pulmonary toxicity of acrylonitrile: covalent interaction and effect of replicative DNA synthesis in the lung. Toxicology. 76:1992;1-4.